Flashcards in Anti-inflammatory Drugs Deck (25)
On a Bronchoconstriction versus log histamine graph- what effect would adding Loratadine have to the curve?
On a Bronchoconstriction vs. log ACh graph what effect would adding Diphenhydramine have?
On a bronchoconstriction vs log AcH graph what effect would adding Fexofenadine have?
Name the leukotriene modifiers
What things are signifigant about indomethacin
very potern, cause frontal headaches, kidney and GI problems
Name the prescription NSAID medications
What are some advantages of SGE Antihistmines?
Do not cause drowsiness, less secretion drying
What enzyme does zileuton block?
Side effect of piroxicam?
Serious GI bleed
Why don't SGA antihistamines cause drowsiness?
Very little crosses the BBB and it has affinity for P-glycoprotein
What enzyme converts Histidine to histamine?
What are the effects of histamine binding with a H1 receptor?
Binding to what Histamine receptor increases gastric acid secretion?
Some effects seen with H1/H2 mixed receptors?
Antihistamines are classsically considered this type of drug? In fact they are this type of drug.
Things that contribute/make hives?
Structural difference between Bradykinin and Kallidin
Bradykinin - 9 aa - ends with Lys
Kallidin - 10 aa - ends with Lys-Arg
Which prostaglandins cause bronchostriction?
PGd and TXA
Which prostaglandin cause many symptoms including vasodilation, increased vascular permeability, pain, redness, and fever?
What effects do peptido leukotrienes have on the body?
swelling, chemotaxis and bronchoconstriction
Bradykinins have numerous effects on the body. Name some of them
swelling, pain, bronchoconstiction, hypotension and redness
Name the first generation antihistamines
Name 3 things that happen in acute inflammation
change in blood vessel caliber and flow
increased vascular permeability
Which anti-inflammatory therapy targets multiple mediators?