Anti-inflammatory Drugs Flashcards Preview

IHO Final > Anti-inflammatory Drugs > Flashcards

Flashcards in Anti-inflammatory Drugs Deck (25):
1

On a Bronchoconstriction versus log histamine graph- what effect would adding Loratadine have to the curve?

Right shift

2

On a Bronchoconstriction vs. log ACh graph what effect would adding Diphenhydramine have?

Right shift

3

On a bronchoconstriction vs log AcH graph what effect would adding Fexofenadine have?

None

4

Name the leukotriene modifiers

zileuton
zafirlukast
montelukast

5

What things are signifigant about indomethacin

very potern, cause frontal headaches, kidney and GI problems

6

Name the prescription NSAID medications

Ketorlac
Indomethacin
Sulindac
Ketoprofen
Piroxicam

7

What are some advantages of SGE Antihistmines?

Do not cause drowsiness, less secretion drying

8

What enzyme does zileuton block?

5-lipoxygenase

9

Side effect of piroxicam?

Serious GI bleed

10

Why don't SGA antihistamines cause drowsiness?

Very little crosses the BBB and it has affinity for P-glycoprotein

11

What enzyme converts Histidine to histamine?

L-histine decarboxylase

12

What are the effects of histamine binding with a H1 receptor?

bronchoconstriction
capillary permeability
itching
pain
hypersensitivity

13

Binding to what Histamine receptor increases gastric acid secretion?

H2

14

Some effects seen with H1/H2 mixed receptors?

Cardiac
Vasodilator
Triple response
Nasal symptoms

15

Antihistamines are classsically considered this type of drug? In fact they are this type of drug.

Antagonist
inverse agonist

16

Things that contribute/make hives?

histamine
prostaglandins
leukotriene

17

Structural difference between Bradykinin and Kallidin

Bradykinin - 9 aa - ends with Lys
Kallidin - 10 aa - ends with Lys-Arg

18

Which prostaglandins cause bronchostriction?

PGd and TXA

19

Which prostaglandin cause many symptoms including vasodilation, increased vascular permeability, pain, redness, and fever?

PGe

20

What effects do peptido leukotrienes have on the body?

swelling, chemotaxis and bronchoconstriction

21

Bradykinins have numerous effects on the body. Name some of them

swelling, pain, bronchoconstiction, hypotension and redness

22

Name the first generation antihistamines

Diphenhydramine
Chlorpheniramine

23

Name 3 things that happen in acute inflammation

change in blood vessel caliber and flow
increased vascular permeability
leukocytic infiltration

24

Which anti-inflammatory therapy targets multiple mediators?

NSAID
anti-inflammatory steroids

25

What effect do bradykinins have on the cardiovascular system?

Decrease BP