Malaria

Question 1

What is the paroxysm occurence for vivax?

Answer 1

48 hrs

Question 2

Name the cell that infects a person via a mosquite bite?

Answer 2

sporozoites

Question 3

What is gold standard for diagnosing malaria?

Answer 3

blood smear

Question 4

Why are rosettes particulary dangerous?

Answer 4

Because they can bind to endothelium, cause hypoxia and ischemia.

Question 5

Which malaria species can become hypnozoite?

Answer 5

vivaxe and ovale?

Question 6

What is the most common malaria species? Most common in Africa?

Answer 6

Vivaxe

Falciprium

Question 7

What life stage is the plasmodium in when it infects RBC?

Answer 7

merozoites

Question 8

What cells does plasmodium initially have tropism for?

Answer 8

hepatic cells

Question 9

Which cytokines are activated by rosettes?

Answer 9

INF, TNFalpha and IL-1

Question 10

Name some things that infer resistance to Malaria?

Answer 10

sickle cell train, blood type, HbC and partial immunity from habitation

Question 11

Describe the mechanism for Chloroquine.

Answer 11

Drug binds FPIX and prevents conversion to hemozoin. FPIX is toxic to cell.

Question 12

Chronic use of Chloroquine can cause this defect?

Answer 12

Blindness

Question 13

When would you use Quinine?

Answer 13

For Cholorquine resistant falciparum.

Question 14

What are the side effects of Quinidine?

Answer 14

Cardiac problems

Question 15

What drug is the radical cure?

Answer 15

Premoquine

Question 16

If Quinine + Doxy is unavailable and you need to treat a patient with Chloroquine resistant vivax what drug would you use?

Answer 16

Mefloroquine

Question 17

List the 5 possible treatments for falciprum?

Answer 17

Chlorquine
Quinine + Doxy
Meflorquine
 Atovaquone+Proguanil
Artemether + Lumefantrine

Question 18

Why are artemeisins never given alone?

Answer 18

To avoid selecting for resistance

Question 19

What enzyme does Proguanil inhibit?

Answer 19

GHFR

Question 20

Which malaria drugs work by inhibiting the ETC?

Answer 20

Premoquine and Atoqaune

Question 21

Neuropschyatiric problems are a side effect of which antimalarial?

Answer 21

Mefloquine

Question 22

G-6-PD is assoiciated most with which malaria drug?

Answer 22

Premoquine

Question 23

3 methods of protection from malaria?

Answer 23

Netting, avoid infested areas, repellant, prophyrlaxis

Question 24

Which drugs are effective against the sporozoite stage of plasmidum?

Answer 24

There are none