Flashcards in ROS Deck (10)
Where is hydrogen peroxide made?
Peroxisomes, RER, mitochondria
What enzyme catalyzes the reaction of hydrogen peroxide (H2O2) to hypochlorous acid (HOCl)?
In what cells is myeloperoxidase most active?
Phagocytes, neutrophils especially, during the oxidative burst phase of phagocytosis
Reactive nitrogen oxygen species all stem from what chemical compound?
Nitric oxide, NO, made by nitric oxide synthase from the transformation of arginine to citrulline
What is the causative genetic defect in chronic granulomatous disease and in what cells is this most detrimental?
NADPH oxidase in phagocytes
What is the problem in CGD?
Not enough hydrogen peroxide is made to destroy catalase positive bacteria (ex. Aspergillosis, S. Aureus, Serratia, Nocardia)
What is the most effective diagnostic test for CGD?
Nitro blue tetrazolium test
What medications will a CGD patient need to take for the rest of their life?
Itraconazole and bactrim
What is ischemia reperfusion injury?