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Flashcards in ROS Deck (10):
0

Where is hydrogen peroxide made?

Peroxisomes, RER, mitochondria

1

What enzyme catalyzes the reaction of hydrogen peroxide (H2O2) to hypochlorous acid (HOCl)?

Myeloperoxidase

2

In what cells is myeloperoxidase most active?

Phagocytes, neutrophils especially, during the oxidative burst phase of phagocytosis

3

Reactive nitrogen oxygen species all stem from what chemical compound?

Nitric oxide, NO, made by nitric oxide synthase from the transformation of arginine to citrulline

4

What is the causative genetic defect in chronic granulomatous disease and in what cells is this most detrimental?

NADPH oxidase in phagocytes

5

What is the problem in CGD?

Not enough hydrogen peroxide is made to destroy catalase positive bacteria (ex. Aspergillosis, S. Aureus, Serratia, Nocardia)

6

What is the most effective diagnostic test for CGD?

Nitro blue tetrazolium test

7

What medications will a CGD patient need to take for the rest of their life?

Itraconazole and bactrim

8

What is ischemia reperfusion injury?

.

10

Reactive nitrogen oxygen species all stem from what chemical compound?

Nitric oxide, NO, made by nitric oxide synthase from the transformation of arginine to citrulline