Anti-depressants Flashcards Preview

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Flashcards in Anti-depressants Deck (27):
1

For mild to moderate depression, what is the clinical indication

Drugs do not show clinical improvement in studies, yet some patients will report improvement within a day or two, others they take weeks and weeks

2

What event do all antidepressants increase the likelihood of

all antidepressants lower the seizure threshold, especially when combined with alcohol; increase in suicidal thinking and/or behavior

3

when would a tricyclic antidepressant be indicated

When the patient also has a hard time falling and/or staying asleep (insomnia)

4

Which antidepressant class has the most severe side effects

MAOI monoamine oxidase inhibitor

5

What dietary restrictions come with MAOI drugs

No high tyramine foods: raisins, aged cheeses and meats, red wine, many soy products

6

What happens if a person on an MAOI eats tyramine containing foods

potentially toxic elevation of catecholamine levels, resulting in severe headaches, nausea and hypertension.
Hypertensive emergencies and fatal accelerated hypertension have been reported

7

What is the MOA of tricyclic antidepressants (TCA)

Diminishing the reuptake of monoamine neurotransmitters is clearly one of the chief effects. Subsequent down regulation of postsynaptic receptors may be the true mechanism of action

8

What are the indications for TCA

obsessive compulsive disorders, enuresis, panic attacks, chronic pain and migraine headaches as well as depression

9

What are side effects of TCA

anti-cholinergic signs and symptoms such as dry mouth, constipation, urinary hesitancy, orthostatic hypotension and sedation

10

What side effect of TCA is of note for men

it causes constriction of the bladder neck, important if the man has BPH

11

What drug class is amitriptyline (Elavil)

tricyclic antidepressant (TCA

12

What are the indications of amitriptyline

major depression, bipolar disorder, migraine and tension headaches, chronic pain

13

What is the MOA of SSRIs

blockade of serotonin reuptake at the pre-synaptic terminal which results in the subsequent increased level of serotonin available for further neurotransmission

14

What are common side effects of SSRIs

increased number of bowel movements, dizziness, HA, fatigue, anxiety, insomnia, impotence, weight gain, nausea

15

What drug class is fluoxetine (prozac)

SSRI

16

What are the indications for fluoxetine (prozac)

Major depressive disorder, obsessive compulsive disorder, bulimia and panic disorder

17

What are symptoms of serotonin syndrome

fever, agitation, diarrhea, elevated BP

18

What drug class is Duloxetine (cymbalta)

serotonine and norepinephrine reuptake inhibitor (SNRI)

19

What are the indications for duloxetine (cymbalta)

neurogenic pain, fibromyalgia, GAD, painful peripheral neuropathy

20

What comorbidity indicates prescription of a tri- or tetra-cyclic antidepressant

insomnia

21

what drug class is trazodone (Desyrel)

tetracyclic antidepressant

22

What are the indications for trazodone (desyrel)

Panic disorder, anxiety, insomnia, MDD

23

What are the side effects of trazodone (desyrel)

sedation, orthostatic hypotension, fatigue, cardiac dysrhythmia, mania in a bipolar patient

24

What drug class is bupropion (wellbutrin)

norepinephrine and dopamine reuptake inhibitor (NDRI) and nicotine receptor agonist

25

What are the indications for bupropion (wellbutrin)

major depression, smoking cessation, bipolar, ADD

26

What are some side effects of bupropion

weight loss, Headache, insomnia, dry mouth, tremors, restlessness, agitation, anxiety, sweating and dizziness

27

What nutrient deficiency is correlated with depression

folate (folic acid) because it is essential for neurotransmitter production