Anxiolytic and Sedatives Flashcards Preview

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Flashcards in Anxiolytic and Sedatives Deck (19)
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1
Q

How does alcohol change the affect of anxiolytics

A

It potentiates their affect

2
Q

How do benzos and barbiturates compare to GABA MOA

A

They have receptors adjacent to GABA receptors, which changes the configuration of the GABA receptor

3
Q

what happens in a barbiturate overdose

A

coma (death from aspiration of vomitus), respiratory depression

4
Q

What is an example of an ulta-short acting barbiturate

A

Thiopental/ Pentothal

5
Q

What is an example of a short acting barbiturate

A

Pentobarbital/ Nembutal

6
Q

What is an example of a medium-acting barbiturate

A

Butalbital/ Fiorinal

7
Q

What is an example of a long-acting barbiturate

A

Phenobarbital/ Luminal

8
Q

What are the indications of phenobarbital

A

anti-seizure, sedative

9
Q

What type of drug is Midazolam (Versed)

A

short-acting benzodiazapene

10
Q

What are the indications of diazepam (Valium)

A

Anxiolytic, sedative, muscle relaxant and seizure control (breakthrough seizure)

11
Q

What drug type is zolpidem (Ambien)

A

short-acting non-benzodiazepine hypnotic

12
Q

What is the MOA of zolpidem (ambien)

A

potentiates GABA by binding to GABAA receptors at the same location as benzodiazepines

13
Q

What are risks of taking zolpidem (ambien)

A

somnabulance with no memory of it (even driving). Take Ambien-CR (controlled release) to help this problem

14
Q

What drug class is Eszopiclone (Lunesta)

A

benzodiazepine-like hypnotic

15
Q

What are side effects of Eszopiclone (Lunesta)

A

Impaired mentation prior to sedation

16
Q

What drug class is Ramelteon

A

melatonin receptor agonist

17
Q

What is a complication of withdrawal from a benzodiazapine or barbiturate

A

Rapid withdrawal can cause death

18
Q

What are Benzo withdrawal symptoms

A

seizure, hallucinations, anxiety, panic attacks, etc can last years

19
Q

What is flumazenil (Romazicon)

A

IV drug used to bring people back from a benzo OD