Medications for Osteoporosis Flashcards Preview

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Flashcards in Medications for Osteoporosis Deck (18)
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1
Q

what sort of calcium supplement should be avoided

A

calcium from oyster shell or bone has a greater risk of carrying lead or other heavy metals

2
Q

How does magnesium help in osteoporosis

A

it aids in diminishing bone loss when taken with Calcium and vitamin D

3
Q

What is protos

A

a drug form of strontium approved for use in Europe for treating osteoporosis

4
Q

What drug class is Alendronate (fosamax)

A

bisphosphonate

5
Q

What is a weird part of the PARQ for alendronate

A

you must remain upright for at least 30 minutes after taking it due to esophageal irritation

6
Q

What are side effects of alendronate (fosamax)

A

Osteonecrosis, atypical femur fractures, myalgias

7
Q

What is the MOA of Bisphosphonate drugs

A

inhibit osteoclast activity

8
Q

What drug class is Raloxifene (Evista)

A

SERM

9
Q

What drug class is Teriparatide

A

synthetic PTH analogue, made from selected amino acids found in parathyroid hormone

10
Q

What is the goal for SERMs (selective estrogen receptor modulator)

A

producing the same benefits that estrogen has on bone density and on lowering cholesterol levels without increasing the risk for hormone-related cancers

11
Q

What is the MOA of Raloxifene

A

Binding to select estrogen receptor sites. This drug developed to maintain beneficial estrogenic activity on bone and lipids and “anti-estrogenic” activity on endometrial and breast tissue

12
Q

What is a side effect of Raloxifene

A

increased DVT and clot risk.

13
Q

How is calcitonin administered

A

Nasal spray

14
Q

What is the MOA of calcitonin

A

Osteoclast inhibition

15
Q

What is calcitonin approved to treat

A

osteoporosis, NOT for osteopenia or prevention

16
Q

What is the MOA of teriparatide (forteo)

A

Activates bone turnover with osteoblasts being activated to a much greater extant than osteoclasts. Stimulates new bone formation in both spine and hip

17
Q

What drug class is Denosumab (prolia)

A

Monoclonal antibody

18
Q

What is the MOA of Denosumab (prolia)

A

targets RANKL (the RANK ligand), a protein that acts as the primary signal to promote bone removal.