Medications for Osteoporosis Flashcards Preview

pharm 2 > Medications for Osteoporosis > Flashcards

Flashcards in Medications for Osteoporosis Deck (18):
1

what sort of calcium supplement should be avoided

calcium from oyster shell or bone has a greater risk of carrying lead or other heavy metals

2

How does magnesium help in osteoporosis

it aids in diminishing bone loss when taken with Calcium and vitamin D

3

What is protos

a drug form of strontium approved for use in Europe for treating osteoporosis

4

What drug class is Alendronate (fosamax)

bisphosphonate

5

What is a weird part of the PARQ for alendronate

you must remain upright for at least 30 minutes after taking it due to esophageal irritation

6

What are side effects of alendronate (fosamax)

Osteonecrosis, atypical femur fractures, myalgias

7

What is the MOA of Bisphosphonate drugs

inhibit osteoclast activity

8

What drug class is Raloxifene (Evista)

SERM

9

What drug class is Teriparatide

synthetic PTH analogue, made from selected amino acids found in parathyroid hormone

10

What is the goal for SERMs (selective estrogen receptor modulator)

producing the same benefits that estrogen has on bone density and on lowering cholesterol levels without increasing the risk for hormone-related cancers

11

What is the MOA of Raloxifene

Binding to select estrogen receptor sites. This drug developed to maintain beneficial estrogenic activity on bone and lipids and “anti-estrogenic” activity on endometrial and breast tissue

12

What is a side effect of Raloxifene

increased DVT and clot risk.

13

How is calcitonin administered

Nasal spray

14

What is the MOA of calcitonin

Osteoclast inhibition

15

What is calcitonin approved to treat

osteoporosis, NOT for osteopenia or prevention

16

What is the MOA of teriparatide (forteo)

Activates bone turnover with osteoblasts being activated to a much greater extant than osteoclasts. Stimulates new bone formation in both spine and hip

17

What drug class is Denosumab (prolia)

Monoclonal antibody

18

What is the MOA of Denosumab (prolia)

targets RANKL (the RANK ligand), a protein that acts as the primary signal to promote bone removal.