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Flashcards in Antipsychotics Deck (33):
1

What is an alternate name for antipsychotics

neuroleptics

2

What are the categories of antipsychotics

typical (first generation) and atypical (2nd and 3rd generation)

3

What is the general MOA of antipsychotics

blocking dopamine receptors

4

What common side effects of antipsychotics (6)

-parkinsonian-like symptoms like tremors, lip smacking, grimacing, etc
-Massive weight gain
-increased prolactin release
-tardive dyskinesia
-extrapyramidal signs
-dry mouth, eyes, constipation, urinary retention

5

What is dyskinesia

involuntary movement. Facial grimacing and involuntary movements of limbs are examples of dyskinesias. Tardive means it continues after discontinuation of the drug

6

What is neuroleptic malignant syndrome

catatonia, fluctuating BP, dysarthria, fever caused by antipsychotic drug

7

What is done for someone with neuroleptic malignant syndrome

administer a dopamine agonist like Bromocriptine

8

What drug class is chlorpromazine (thorazine)

typical neuroleptic

9

What is the MOA of chlorpromazine (thorazine)

D2 dopaminergic receptor site blockade and H1 histamine blocker, alpha adrenergic blocker

10

What is a common side effect of chlorpromazine

inceased prolactin d/t dopamin blockade

11

What drug class is prochlorperazine (compazine)

typical neuroleptic

12

What are the indications for prochlorperazine (compazine)

Psychosis as well as vertigo and nausea and vomiting, particularly when associated with migraine headaches

13

What category is prochlorperazine (compazine)

category C

14

what drug class is haloperidol (Haldol)

typical neuroleptc

15

What are the indications of haloperidol (Haldol)

Sun-downing, Psychosis, Tourette’s syndrome, Huntington’s disease, acute agitated behavior (combative)

16

What are the main side effects of haloperidol (haldol)

extrapyramidal effects, tremors, mb neuroleptic malignant syndrome

17

What drug class is clozapine (clozaril)

Atypical neuroleptic

18

What is the MOA of clozapine (clozaril)

D2 blockade and 5-HTP

19

What are side effects of clozapine

agranulocytosis, myocarditis, diminished extrapyramidal effects compared to others

20

What are the indications for clozapine

schizophrenia

21

What are the side effects of respiradone (risperdal)

Weight gain (40lb in a month), hyperglycemia, diabetes. increase stroke risk in elderly

22

What drug class is respiradone (risperdal)

Atypical neuroleptic

23

What is an important characteristic of respiradone

processed by cyp450

24

How does respiradone (risperdal) compare in side effects to typical neuroleptics

It causes much more significant weight gain, but was touted to cause fewer Parkinsonian and dyskinesia side effects

25

What tests should be run regularly for anyone on neuroleptic drugs

liver function

26

What drug class is Olanzapine (zyprexa)

atypical neuroleptic

27

What are the most common side effects of Olanzapine

Weight gain, hyperglycemia and diabetes. Increased risk for stroke in elderly patients. (same as respiradone)

28

What are the indications for Olanzapine (zyprexa)

Schizophrenia, especially when other antipsychotic agents have failed or have produced undesirable side effects

29

What is the MOA of Olanzapine (zyprexa)

Multiple receptor site blockade yet greatest effects at D2 and 5-HT2 receptor sites

30

What are the indications for lithium salts (Eskalith)

bipolar and maniac episodes. schizophrenia. Off-label for OCD

31

What are the dangers of using lithium

Very narrow TI, so blood levels must be checked frequently (every week)

32

What is the most common renal side effect of lithium

Impaired concentration capacity due to reduced renal response to antidiuretic hormone (ADH), causing nephrogenic diabetes insipidus

33

What side effect of lithium develops in 5-35% of patients

hypothyroidism