Corticosteroids Flashcards Preview

pharm 2 > Corticosteroids > Flashcards

Flashcards in Corticosteroids Deck (18)
Loading flashcards...
1
Q

How potent of an anti-inflammatory is the corticosteroid drug class

A

They are the most potent of our anti-inflammatory drugs

2
Q

As a corticosteroid has greater the anti-inflammatory effect, what happens to the mineralocorticoid effect

A

The less the mineralocorticoid effect, and vice versa

3
Q

What is tachyphylaxis

A

A rapid decrease in response to a drug over a relatively short period of time (a week or two). Seen commonly with topical corticosteroids

4
Q

What is the order of steroid duration of action, from short to longest

A

hydrocortisone - 8-12 hours
Prednisone - 18-36 hours
dexamethasone, betamethasone - 24-72+ hours

5
Q

Why must corticosteroids be tapered off

A

Abrupt withdrawal can lead to exacerbation of the underlying disease as well acute adrenal insufficiency syndrome aka Addisonian crisis which can be a lethal event

6
Q

What are signs of addisonian crisis

A

Low BP, severe lethargy, severe vomiting, diarrhea, confusion, LOC, hyponatremia and hypoglycemia

7
Q

What is hydrocortisone (Cortef)

A

Bioidentical cortisol drug

8
Q

How is hydrocortisone used

A

PO, IV, IM (be careful), and most commonly topically

9
Q

What disease is prednisone (Deltasone) the preferred drug for

A

Reactive airway disease or moderate to severe allergic reaction. Leukemia reaction, AI, collagen vascular dz

10
Q

What is the MOA of prednisone

A

affects gene transcription to either stimulate or repress protein production

11
Q

What drug class is Dexamethasone (decadron)

A

fluorinated corticosteroid

12
Q

What is the MOA of dexamethasone (decadron)

A

Affects gene transcription to either stimulate or repress protein production

13
Q

When is triamcinolone (azmacort) indicated

A

for use in asthma, COPD. Not acute asthma

14
Q

What are the indications of beclomethasone

A

prophylaxis of asthma (inhaler); rhinitis, had fever, sinusitis (nasal spray); rarely for bad aphthous ulcers

15
Q

What is seen in Conn’s disease

A

Increased aldosterone, which causes sodium retention and HTN

16
Q

What drug class is fludrocortisone (florinef)

A

Halogenated glucocorticoid/ Mineralocorticoid agonist

17
Q

What are the indications of fludrocortisone

A

Addison’s disease or other cases of hyponatremia

18
Q

What is the MOA of fludrocortisone

A

Sodium retention. Main effect is via reduction of sodium loss to the urine at the renal tubular cells