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Flashcards in Corticosteroids Deck (18):
1

How potent of an anti-inflammatory is the corticosteroid drug class

They are the most potent of our anti-inflammatory drugs

2

As a corticosteroid has greater the anti-inflammatory effect, what happens to the mineralocorticoid effect

The less the mineralocorticoid effect, and vice versa

3

What is tachyphylaxis

A rapid decrease in response to a drug over a relatively short period of time (a week or two). Seen commonly with topical corticosteroids

4

What is the order of steroid duration of action, from short to longest

hydrocortisone - 8-12 hours
Prednisone - 18-36 hours
dexamethasone, betamethasone - 24-72+ hours

5

Why must corticosteroids be tapered off

Abrupt withdrawal can lead to exacerbation of the underlying disease as well acute adrenal insufficiency syndrome aka Addisonian crisis which can be a lethal event

6

What are signs of addisonian crisis

Low BP, severe lethargy, severe vomiting, diarrhea, confusion, LOC, hyponatremia and hypoglycemia

7

What is hydrocortisone (Cortef)

Bioidentical cortisol drug

8

How is hydrocortisone used

PO, IV, IM (be careful), and most commonly topically

9

What disease is prednisone (Deltasone) the preferred drug for

Reactive airway disease or moderate to severe allergic reaction. Leukemia reaction, AI, collagen vascular dz

10

What is the MOA of prednisone

affects gene transcription to either stimulate or repress protein production

11

What drug class is Dexamethasone (decadron)

fluorinated corticosteroid

12

What is the MOA of dexamethasone (decadron)

Affects gene transcription to either stimulate or repress protein production

13

When is triamcinolone (azmacort) indicated

for use in asthma, COPD. Not acute asthma

14

What are the indications of beclomethasone

prophylaxis of asthma (inhaler); rhinitis, had fever, sinusitis (nasal spray); rarely for bad aphthous ulcers

15

What is seen in Conn's disease

Increased aldosterone, which causes sodium retention and HTN

16

What drug class is fludrocortisone (florinef)

Halogenated glucocorticoid/ Mineralocorticoid agonist

17

What are the indications of fludrocortisone

Addison's disease or other cases of hyponatremia

18

What is the MOA of fludrocortisone

Sodium retention. Main effect is via reduction of sodium loss to the urine at the renal tubular cells