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Flashcards in Gout medications Deck (22):
1

What causes elevated uric acid

Making too much or not getting rid of it effectively

2

What do urocusuric class medications do

increases urine secretion of uric acid

3

What does an anti-urocusuric class of drug do

Withhold uric acid from the urine (aspirin, HCTZ, lasix)

4

What treatment is used in an acute gouty attack

NSAIDs
Steroids
Colchicine

5

What treatments can be used as gout attack prophylaxis

Colchicine
Allopurinol
Probenecid

6

What drug class is Indomethacin

NSAID

7

What are the indications of indomethacin

Gout, arthritis, bursitis, migraines, hemicrania, pain and swelling

8

What is the MOA of cortisone injection

Inhibits pro-inflammatory proteins

9

What are some side effects of intra-articular cortisone injections

pain, infection, skin pigment changes, loss of fatty tissue and tendon rupture. (Plus all the usual systemic side effects)

10

What drug class is colchicine

Mitotic inhibitor

11

What is the indication for using colchicine

Gout, acute and prophylaxis

12

What is MOA of colchicine

inhibits polymerization by binding to tubulin, one of the main constituents of microtubles. Colchicine also inhibits neutrophil motility and neutrophil activity, resulting in an anti-inflammatory effect

13

What are some side effects of colchicine

Marked GI upset, Peripheral neuropathy, hair loss, anemia, neutropenia

14

What are colchicine OD symptoms

vomiting, diarrhea, acute renal failure and possible hypovolemic shock. put the patient on dialysis because there is no antidote

15

What drug class is allopurinol (zyloprim)

purine analog

16

What are the indications for allopurinol (zyloprim)

hyperuricemia, gout, prophylaxis against tumor lysis syndrome

17

What is the MOA of Allopurinol

Xanthine oxidase inhibitor. (Decreases the production of uric acid)

18

What drug class is Probenecid (Probalan)

uricosuric

19

What is the MOA of probenecid (probalan)

interfers with the kidneys' organic anion transporter (OAT), which reclaims uric acid from the urine and returns it to the plasma, thereby increasing excretion of uric acid in the urine

20

Who is most at risk for serious side effects from probenecid (probalan)

Someone with a G-6-PD deficiency

21

What are significant side effects of probenecid (probalan) use (2)

1. Formation of uric acid renal stones (particularly in someone with renal insufficiency). patient should drink extra water to prevent stone formation.
2. Exacerbation of gout following therapy with Probenecid may occur.

22

Who always has elevated uric acid levels

Someone with a solid tumor, but particularly people with ALL, are at risk for acute renal failure due to increased uric acid from lysing the tumor(s).