Anti-viral agents Flashcards Preview

Microbiology Block 1 > Anti-viral agents > Flashcards

Flashcards in Anti-viral agents Deck (38):
1

what should a succesful antiviral do?

1) interfere with a virus-specific function

2) interefere with a cellular function to stop viral replication

2

what can viruses do that may render them immune to antiviral drugs?

they develop resistance because they have high mutation rate

3

what is imiquimod?

an antiviral drug

4

what is resiquimod?

antiviral drug

5

what viruses will imiquimod target?

1) HPV

2) molluscum contagiosum

6

what viruses will resiquimod target?

1) HPV

2) molluscum contagiosum

7

what is pegylated interferon-a?

anti-viral drug

8

what is pegylated interferon-a mode of action?

binds to IFN receptro and inhibits translation causing apoptosis of target

9

what viruses does pegylated interferon-a target?

HSV, HPV, Hep B, CMV, Hep C

10

what side effects does interferon-a have?

pleotropic systemic effects (fever, fatigue, headache)

11

what are the 2 types of attachment inhibitors?

1) neutralizing IgG antibodies

2) receptor antagonists

12

how do neutralizing IgG antibodies (a type of attachment inhibitor) work?

through passive immunization, IgG coats virion particles so that the VAP cannot bind to the host cell receptor

13

how do receptor antagonists work (a type of attachment inhibitor)?

sugar or peptide analogues of cell receptor or VAP

14

what is an example of a receptor antagonist drug?

when is it used?

what is the mode of action?

Maraviroc

HIV

binds to CCR5, blocking interaction with gp120

15

Give 2 examples of penetration inhibitors

1) tromantadine

2) enfuvirtide 

16

what will tromantadine inhibit?

HSV penetration

17

what does enfuvirtide inhibit?

inhibits fusion of gp41 with host cell

18

give 2 examples of uncoating inhibitor drugs

1) amantadine

2) remantadine

19

what drugs are used against influenza A?

uncoating inhibitors

20

what will genome replication inhibitors do?

will prevent chain elongation or induce inactivating mutations

21

genome replication inhibitor drugs will target what?

1) RNA polymerase

2) DNA polymerase

3) Reverse transcriptase

22

what is a nucleoside RNA polymerase inhibitor?

a genome replication inhibitor that acts as a nucleoside analogue (has modified nucleoside bases)

23

what is an example of a nucleoside RNA polymerase inhibitor?

Ribavarin

24

what disease can ribovarin be used?

Hep C

RSV

25

what specific target will ribovirin inhibit?

inosine Dehydrogenase

26

what are nucleoside DNA polymerase inhibitors?

nucleoside analogues with modified sugar residues

27

what is characteristic about nucleoside DNA polymerase inhibitors?

they all end with -lovir

28

what is the mechanism of action of nucleoside DNA polymerase inhibitors?

they prevent dna chain elgongation 

29

what are 2 nucleoside DNA polymerase inhibitors?

1) acyclovir

2) ganciclovir

30

what causes the elongation inhibition when using acyclovir?

it is missing -OH on the sugar

31

what viruses are treated with acyclovir?

HSV 1/2

VZV

32

why will acyclovir not work with CMV?

CMV does not have thymidine kinase

33

why is ganciclovir used lightly?

it is toxic

used only for immunocompromised patients

34

what is characteristic about nucleoside transcriptase inhibitors?

they all end with -FOVIR or -UDINE

35

what is the mechanism of action of nucleoside reverse transcriptase inhibitors?

they prevent DNA chain elongation 

36

what are 5 examples of nucleoside reverse transcriptase inhibitors?

1) Tenofovir

2) Adefovir

3) Zidovudine

4) Lamivudine

5) Abacavir

37

when is tenofovir used?

HIV

HBV

38

when is adefovir used?

HIV

HBV