Non-enveloped DNA Viruses Flashcards
(104 cards)
1
Q
what are the DNA naked icosahedral viruses?
A
1) HPV
2) Polyoma
3) Adenovirus
4) Parvovirus B19
2
Q
is HPV double or single stranded?
is polyoma double or single stranded?
is adenovirus double or single stranded?
is parvovirus B19 double or single stranded?
A
HPV = double
polyoma = double
adenovirus = double
parvovirus B19 = single
3
Q
what serology of HPV causes cutaneous warts?
A
1 and 4
4
Q
what serology of HPV causes genital warts?
A
6 and 11
5
Q
what serology of HPV causes cervical cancer?
A
16 and 18
6
Q
what disease does BK virus cause?
A
renal disease
7
Q
what disease does JC virus cause?
A
progressive multifocal leukoencephalopahty
8
Q
HPV, BK and JC viruses belong to what family of viruses?
A
Papovirus
9
Q
how do you diagnose HPV?
A
warts with hyperkeratosis
cervical cells that are koilocytic on a pap smear
10
Q
what HPV proteins later the cell cycle control?
A
E6 and E7
11
Q
what does HPV protein E6 inhibit?
A
p53
12
Q
what does HPV protein E7 inhibit?
A
Rb
13
Q
what vaccine helps prevent HPV? and what strains?
A
gardasil for strains 6, 11, 16, 18
14
Q
what does the early genes of the HPV virus stimulate?
A
cell growth
15
Q
how many types of HPV virus types are there?
A
100
16
Q
what does the high risk HPV strains 16,18 lead to?
A
development of cervical intraepithelial neoplasia
17
Q
what strains of HPV virus cause skin warts? what riks do these strains pose?
A
1-4
these are low risk
18
Q
how common is HPV?
A
it is one of the most prevalent STD’s
19
Q
HPV is present in what type of cancer?
A
cervical cancer
20
Q
what are the 2 ways HPV can be transmitted?
A
direct contact and sexual transmission
21
Q
how does HPV get transmitted through direct contact?
what risk does it pose? strains passed?
A
through small cracks in the skin and will pose low risk
strains 1-4 will get transmitted this way
22
Q
in birth with a woman who has laryngeal papillomas, what serotypes cause it?
A
6 and 11
23
Q
what viral proteins induce the hyperkeratosis or warts?
A
E6/E7
24
Q
how do the warts for HPV induced by E6/E7 look like?
A
coliflower
25
what is a wart?
its a benign proliferation of skin that regresses with time
26
what serotypes of HPV cause cutaneous (skin) warts?
1-4
27
where do we commonly find skin warts caused by HPV?
body, flat (face), plantar (feet)
28
when the HPV skin warts spread througout the body, how is this condition known? this condition can lead to what?
epidermodysplasia verruciformism
can lead to squamous cell carcinoma
29
HPV causes laryngeal papilloma by what strands of the virus?
6 and 11
30
does HPV cause anogenital warts?
true
31
what is condyloma accuminata? where does it happen? what strains of HPV cause them?
anogenital warts, happens in squamous epithelium of external genitalia and perianal area
strains 6 & 11
32
genital cancers (cervical, penile and vulvar) are associated with what strains of HPV?
16 and 18
33
what strains cause Cervical Intraepithelial Neoplasia? what can it lead to?
16 and 18
it may lead to cervical cancer
34
how do you diagnose HPV?
cutaneous and mucosal warts with hyperkeratosis
do a pap smear and look for cervical dysplasia
35
what will a pap smear with cells show?
perinuclear cytoplasmic vacuolization or koilocytosis
36
what vaccine will prevent against HPV? what strains?
Gardasil,
strains: 6, 11, 16, 18
37
what are the human polyomaviruses?
Bk and JC (john cunningham) viruses
38
what type of virus is human polyomavirus?
naked double stranded DNA
39
what disease will JC virus cause? how is the onset?
Progressive Multiple Leukoencephalopathy that has a slow onset
40
what disease will Bk virus cause?
renal disease
41
what is progressive multifocal leukoencephalopathy?
Speech, vision, coordination, mental status, or a combination of these functions is impaired, followed by paralysis of the arms and legs and finally death.
42
what does JC virus do?
JC virus partially transforms astrocytes and kills oligodendrocytes, causing characteristic lesions and sites of demyelination
43
where do you see BK virus with hemorragic cystitis?
AIDS and transplant patients on immuno-suppressants
44
what type of virus is the Adenovirus?
naked double stranded DNA
45
what structure is characteristic of the adenovirus?
it has fibers that are cytotoxic
46
who gets a vaccine against adenovirus?
military personnel
47
where do children get adenovirus from commonly?
pools
48
how is the adenovirus capsid?
icosahedral
49
what do adenovirus fibers contain?
viral attachment protein that function for haemagglutinin
50
how many serotypes are there for adenovirus?
55
51
is adenovirus stable in the environment?
yes
52
is adenovirus contagious?
yes
53
is adenovirus resistant to disinfectants?
yes
54
can adenovirus resist the hostile environment of the human gut?
yes
55
children infected with adenovirus usually present with what?
Upper Respiratory Tract Infection and pink eye
56
how do military personnel usually present with when infected with adenovirus?
upper respiratory tract infection or acute respiratory disease
57
what serotype of adenovirus infects military personnel?
4, 7 and 11
58
what serotypes of adenovirus infects children?
1,2,5,6
59
what particle does adenovirus use to transmit itself to other hosts?
fomites
60
what 4 ways does adenovirus use to transmit itself and infect?
1) respiratory droplets when coughing
2) fecal-oral route by not washing hands and touching surfaces
3) low chlorinated pools
4) fomites in towels and instruments
61
what specific cells are targeted and infected mainly by adenovirus? what damage is inflicted to these cells?
mucoepithelial cells of the respiratory tract or conjunctiva or cornea
they are damaged because adenoviruse lyses these cells
62
what is the characteristic histological feature of adenovirus?
intranuclear basophilic inclusion bodies
63
how does the adenovirus follicular conjunctivitis look like? who gets it?
red conjunctiva with no pus
children
64
who gets epidemic keratoconjunctivitis?
adults
65
what is keratoconjunctivitis?
conjunctivitis followed by keratitis or sense of foreign body in eye (sandy eyes)
66
is epidemic keratoconjunctivitis contagious?
yes
67
is there pus in epidemic keratoconjunctivits?
no
68
what serotypes of adenovirus cause acute respiratory disease in military personnel?
4, 7, 21
69
how does adenovirus acute respiratory disease present like?
fever, flu like symtpoms, couch
70
what is the main adenovirus types?
4 y 7
71
adenovirus is a major causator of what stomach disease?
acute viral gastroenteritis
72
what is the major clue to identefying adenovirus? what do you look for?
histology, you look for intra-nuclear basophilic inclusion bodies
73
what type of vaccine is given to the military for prevention? what serotypes does the vaccine work against?
live oral vaccine
works for 4, 7, 21
74
what kind of inclusion is seen here?
what virus causes this?
basophilic intra-nuclear inclusion
adenovirus
75
what virus causes this? what is seen in the picture?
adenovirus
kerato-conjunctivitis
76
what virus causes this?
what are you seeing in the picture?
adenovirus
follicular conjunctivitis (pebbled or nodular)
77
what virus causes this?
what is seen in the picture?
HPV
coliflower looking skin warts
78
how are these cells called? what virus causes it? with what procedure can you acquire a sample of these cell?
koilocytic (perinuclear cytoplasmic vacuolization)
caused by HPV
pap smear
79
what virus causes this?
what type of hyperkeratosis is this?
HPV
anogenital wart
80
what type of growth is this?
what virus causes it?
coliflower genital warts
HPV
81
what virus causes this?
what is this in the picture?
HPV
skin warts
82
what kind of virus is Parvovirus B19?
what is characteristic about Parvovirus B19?
it is a single stranded naked DNA virus
it is the smallest
83
what cells does Parvovirus B19 target?
erythroid precursor cells
84
what does Parvovirus B19 cause in kids?
erythema infectiosum or 5th disease
85
what does Parvovirus B19 cause in adults?
acute polyarthritis (joint pain)
86
what does Parvovirus B19 cause in pregnant women?
hydrops fetalis
87
is Parvovirus B19 an enveloped virus?
no
88
how many serotypes are there for Parvovirus B19?
1
89
in what cells does Parvovirus B19 replicate in?
mitotically active cells
90
how is Parvovirus B19 transmitted?
what type of transmission does it have?
through respiratory droplets (sneezing)
has vertical transmission
91
what individuals are at risk of infection with parvovirus?
children, pregnant women and individuals with chronic anemia
92
what is vertical transmission?
when mother can pass it to baby
93
when does Parvovirus B19 pose the biggest threat to pregnant women? why?
in the 1st trimester, may induce miscarriage
94
what may Parvovirus B19 cause in individuals with hemolytic anemia or chronic anemia?
it will cause aplastic chrisis or reticulocytopenia
95
in what trimester does vertical trasmission of Parvovirus B19 occur in pregnancy?
in the 3rd trimester
96
what process is disturbed when Parvovirus B19 infects erythroid precursor cells?
erythropoiesis
97
what is the viral receptor in erythroid precursor cells in order for Parvovirus B19 to target the cell?
globosides
98
how will kids infected by Parvovirus B19 present when they have erythema infectiosum?
with fever, 7-10 after exposure
flu like symptoms
slight decrease in hemoglobin
**slapped cheek look (red cheeks)**
99
will adults exhibit slapped cheek if infected by Parvovirus B19?
no
100
what is another name for erythema infectiosum?
can this spread to other parts of the skin?
when does it go away?
erythematous macular rash
yes, it may spread to exposed skin in a lacy pattern
subsides after initial cheek rash
101
what virus causes this?
what is this symptom called?
Parvovirus B19
slapped cheek
102
what virus causes this?
what is this symptom called?
Parvovirus B19
slapped cheek
103
what is a requirement for Parvovirus B19 to cause hydrops fetalis in pregnant women?
mother must be sero-negative
104
how can you check if mother is serotonegative for Parvovirus B19 during pregnancy?
check if during infection she has IgM or IgG (IgM means 1st time infection, IgG measn recurring infection)
