Non-enveloped DNA Viruses Flashcards Preview

Microbiology Block 1 > Non-enveloped DNA Viruses > Flashcards

Flashcards in Non-enveloped DNA Viruses Deck (104):
1

what are the DNA naked icosahedral viruses?

1) HPV

2) Polyoma

3) Adenovirus

4) Parvovirus B19

2

is HPV double or single stranded?

is polyoma double or single stranded?

is adenovirus double or single stranded?

is parvovirus B19 double or single stranded?

HPV = double

polyoma = double

adenovirus = double 

parvovirus B19 = single

3

what serology of HPV causes cutaneous warts?

1 and 4

4

what serology of HPV causes genital warts?

6 and 11

5

what serology of HPV causes cervical cancer?

16 and 18

6

what disease does BK virus cause?

renal disease

7

what disease does JC virus cause?

progressive multifocal leukoencephalopahty 

8

HPV, BK and JC viruses belong to what family of viruses?

Papovirus

9

how do you diagnose HPV?

warts with hyperkeratosis

cervical cells that are koilocytic on a pap smear

10

what HPV proteins later the cell cycle control?

E6 and E7

11

what does HPV protein E6 inhibit?

p53

12

what does HPV protein E7 inhibit?

Rb

13

what vaccine helps prevent HPV? and what strains?

gardasil for strains 6, 11, 16, 18

14

what does the early genes of the HPV virus stimulate?

cell growth

15

how many types of HPV virus types are there?

100

16

what does the high risk HPV strains 16,18 lead to?

development of cervical intraepithelial neoplasia

17

what strains of HPV virus cause skin warts? what riks do these strains pose?

1-4

these are low risk

18

how common is HPV?

it is one of the most prevalent STD's 

19

HPV is present in what type of cancer?

cervical cancer

20

what are the 2 ways HPV can be transmitted?

direct contact and sexual transmission

21

how does HPV get transmitted through direct contact?

what risk does it pose? strains passed?

through small cracks in the skin and will pose low risk 

strains 1-4 will get transmitted this way

22

in birth with a woman who has laryngeal papillomas, what serotypes cause it?

6 and 11

23

what viral proteins induce the hyperkeratosis or warts?

E6/E7

24

how do the warts for HPV induced by E6/E7 look like?

coliflower

25

what is a wart?

its a benign proliferation of  skin that regresses with time

26

what serotypes of HPV cause cutaneous (skin) warts?

1-4

27

where do we commonly find skin warts caused by HPV?

body, flat (face), plantar (feet)

28

when the HPV skin warts spread througout the body, how is this condition known? this condition can lead to what?

epidermodysplasia verruciformism

 

can lead to squamous cell carcinoma

29

HPV causes laryngeal papilloma by what strands of the virus?

6 and 11

30

does HPV cause anogenital warts?

true

31

what is condyloma accuminata? where does it happen? what strains of HPV cause them?

anogenital warts, happens in squamous epithelium of external genitalia and perianal area

strains 6 & 11

32

genital cancers (cervical, penile and vulvar) are associated with what strains of HPV?

16 and 18

33

what strains cause Cervical Intraepithelial Neoplasia? what can it lead to?

16 and 18

it may lead to cervical cancer

34

how do you diagnose HPV?

cutaneous and mucosal warts with hyperkeratosis 

do a pap smear and look for cervical dysplasia

35

what will a pap smear with cells show?

perinuclear cytoplasmic vacuolization or koilocytosis 

36

what vaccine will prevent against HPV? what strains?

Gardasil,

strains: 6, 11, 16, 18

37

what are the human polyomaviruses?

Bk and JC (john cunningham) viruses

38

what type of virus is human polyomavirus?

naked double stranded DNA

39

what disease will JC virus cause? how is the onset?

Progressive Multiple Leukoencephalopathy that has a slow onset

40

what disease will Bk virus cause?

renal disease

41

what is progressive multifocal leukoencephalopathy?

Speech, vision, coordination, mental status, or a combination of these functions is impaired, followed by paralysis of the  arms and legs and finally death.

42

what does JC virus do?

JC virus partially transforms astrocytes and kills  oligodendrocytes, causing characteristic lesions and sites of demyelination

43

where do you see BK virus with hemorragic cystitis?

AIDS and transplant patients on immuno-suppressants

44

what type of virus is the Adenovirus?

naked double stranded DNA

45

what structure is characteristic of the adenovirus?

it has fibers that are cytotoxic

46

who gets a vaccine against adenovirus?

military personnel 

47

where do children get adenovirus from commonly?

pools

48

how is the adenovirus capsid?

icosahedral

49

what do adenovirus fibers contain?

viral attachment protein that function for haemagglutinin

50

how many serotypes are there for adenovirus?

55

51

is adenovirus stable in the environment?

yes

52

is adenovirus contagious?

yes

53

is adenovirus resistant to disinfectants?

yes

54

can adenovirus resist the hostile environment of the human gut?

yes

55

children infected with adenovirus usually present with what?

Upper Respiratory Tract Infection and pink eye

56

how do military personnel usually present with when infected with adenovirus?

upper respiratory tract infection or acute respiratory disease

57

what serotype of adenovirus infects military personnel?

4, 7 and 11

58

what serotypes of adenovirus infects children?

1,2,5,6

59

what particle does adenovirus use to transmit itself to other hosts?

fomites

60

what 4 ways does adenovirus use to transmit itself and infect?

1) respiratory droplets when coughing 

2) fecal-oral route by not washing hands and touching surfaces

3) low chlorinated pools

4) fomites in towels and instruments

61

what specific cells are targeted and infected mainly by adenovirus? what damage is inflicted to these cells?

mucoepithelial cells of the respiratory tract or conjunctiva or cornea

they are damaged because adenoviruse lyses these cells

62

what is the characteristic histological feature of adenovirus?

intranuclear basophilic inclusion bodies

63

how does the adenovirus follicular conjunctivitis look like? who gets it?

red conjunctiva with no pus

 children

64

who gets epidemic keratoconjunctivitis?

adults

65

what is keratoconjunctivitis?

conjunctivitis followed by keratitis or sense of foreign body in eye (sandy eyes)

66

is epidemic keratoconjunctivitis contagious?

yes

67

is there pus in epidemic keratoconjunctivits?

no

68

what serotypes of adenovirus cause acute respiratory disease in military personnel?

4, 7, 21

69

how does adenovirus acute respiratory disease present like?

fever, flu like symtpoms, couch 

70

what is the main adenovirus types?

4 y 7

71

adenovirus is a major causator of what stomach disease?

acute viral gastroenteritis

72

what is the major clue to identefying adenovirus? what do you look for?

histology, you look for intra-nuclear basophilic inclusion bodies

73

what type of vaccine is given to the military for prevention? what serotypes does the vaccine work against?

live oral vaccine

works for 4, 7, 21

74

what kind of inclusion is seen here? 

what virus causes this?

Q image thumb

basophilic intra-nuclear inclusion 

adenovirus

75

what virus causes this? what is seen in the picture?

adenovirus 

kerato-conjunctivitis

76

what virus causes this? 

what are you seeing in the picture?

adenovirus

follicular conjunctivitis (pebbled or nodular)

77

what virus causes this?

what is seen in the picture?

Q image thumb

HPV

coliflower looking skin warts

78

how are these cells called? what virus causes it? with what procedure can you acquire a sample of these cell?

Q image thumb

koilocytic (perinuclear cytoplasmic vacuolization) 

caused by HPV

pap smear

79

what virus causes this?

what type of hyperkeratosis is this?

Q image thumb

HPV

anogenital wart

80

what type of growth is this?

what virus causes it?

coliflower genital warts

HPV

81

what virus causes this?

what is this in the picture?

Q image thumb

HPV

skin warts

82

what kind of virus is Parvovirus B19?

what is characteristic about Parvovirus B19?

it is a single stranded naked DNA virus

it is the smallest 

83

what cells does Parvovirus B19 target?

erythroid precursor cells

84

what does Parvovirus B19 cause in kids?

erythema infectiosum or 5th disease

85

what does Parvovirus B19 cause in adults?

acute polyarthritis (joint pain)

86

what does Parvovirus B19 cause in pregnant women?

hydrops fetalis 

87

is Parvovirus B19 an enveloped virus?

no

88

how many serotypes are there for Parvovirus B19?

1

89

in what cells does Parvovirus B19 replicate in?

mitotically active cells

90

how is Parvovirus B19 transmitted?

what type of transmission does it have?

through respiratory droplets (sneezing)

has vertical transmission

91

what individuals are at risk of infection with parvovirus?

children, pregnant women and individuals with chronic anemia

92

what is vertical transmission?

when mother can pass it to baby

93

when does Parvovirus B19 pose the biggest threat to pregnant women? why?

in the 1st trimester, may induce miscarriage

94

what may Parvovirus B19 cause in individuals with hemolytic anemia or chronic anemia?

it will cause aplastic chrisis or reticulocytopenia

95

in what trimester does vertical trasmission of Parvovirus B19 occur in pregnancy?

in the 3rd trimester

96

what process is disturbed when Parvovirus B19 infects erythroid precursor cells?

erythropoiesis 

97

what is the viral receptor in erythroid precursor cells in order for Parvovirus B19 to target the cell?

globosides 

98

how will kids infected by Parvovirus B19 present when they have erythema infectiosum?

with fever, 7-10 after exposure

flu like symptoms

slight decrease in hemoglobin 

slapped cheek look (red cheeks)

99

will adults exhibit slapped cheek if infected by Parvovirus B19?

no

100

what is another name for erythema infectiosum?

can this spread to other parts of the skin?

when does it go away?

erythematous macular rash

yes, it may spread to exposed skin in a lacy pattern

subsides after initial cheek rash

101

what virus causes this?

what is this symptom called?

Q image thumb

Parvovirus B19

slapped cheek

102

what virus causes this?

what is this symptom called?

Q image thumb

Parvovirus B19

slapped cheek

103

what is a requirement for Parvovirus B19 to cause hydrops fetalis in pregnant women? 

 

mother must be sero-negative

104

how can you check if mother is serotonegative for Parvovirus B19 during pregnancy?

check if during infection she has IgM or IgG (IgM means 1st time infection, IgG measn recurring infection)