+RNA Hepatitis (Hep A, Hep E, Hep C) Flashcards Preview

Microbiology Block 1 > +RNA Hepatitis (Hep A, Hep E, Hep C) > Flashcards

Flashcards in +RNA Hepatitis (Hep A, Hep E, Hep C) Deck (54):
1

are symptoms distinguishible for all hepatitis?

no, they are all almost the same

2

what are some of the symptoms that are indicative of Hepatitis?

fever

jaundice (icterus)

hepatomegaly

GI dysfunction (anorexia, nausea, vomiting)

3

what lab studies can be indicative of hepatitis?

ALT (alanine aminotransferase) and AST (aminotransferase)

4

what cases of hepatitis resolves by itself?

hepatitis A

5

Chronic infection with  HBV and HCV leads to what?

fibrosis, cirrhosis and hepatocellular carcinoma (HCC).

6

what is another name for Fulminant Hepatitis?

acute liver failure

7

what is Fulminant Hepatitis?

what is the treatment?

rare fatal rapid deterioration of liver associated with toxic encephalopathy

 

liver transplantation 

8

what lab techniques should be ordered in all cases of hepatitis?

viral serology panel and PCR

9

a viral serology panel for hepatitis A showing Anti-HAV IgM antibodies is indicative of what? 

and if we see Anti-HAV IgG

current or first infection with hep A

 

recurrent infection with hep A

10

what is viral hepatitis?

Is an inflammatory disease of the liver that is caused by one or more of hepatitis viruses.

11

all hepatitis viruses are known as what?

Hepatotropic viruses

12

all hepatitis virus are what kind nucleic acid?

who is the exception?

hepatitis A, C, D, E are RNA viruses 

hepatitis B is the only DNA virus

13

all hepatitis viruses are capable of causing what symptom? it may lead to progression to what?

acute hepatitis that may progress to chronic hepatitis

14

what is the clinical presentation of acute viral hepatitis?

Jaundice**

Dark urine**

Fever** 

 anorexia

Markedly Elevated liver enzymes (ALT>AST)

15

how long does acute viral hepatitis symptoms lasts?

6 months

16

what causes the release of AST and ALT into the blood? (leading to higher levels)

hepatocyte necrosis

17

what hepatitis viruses cause chronic viral hepatitis?

hepatitis B, C, D

18

what is the most common cause of chronic viral hepatitis?

hepatitis C

19

chronic viral hepatitis has an increased risk of leading to what?

cirrhosis and hepatocellular carcinoma

20

hepatitis from alcohol or drugs will have no association with what symptom?

 no fever

21

hepatitis from gallstones will present with what?

high bilirubin and low AST and ALT

22

how do you differantiate between viral hepatitis from hepatitis caused by other viruses?

hepatitis viruses do not cause systemic symptoms

23

acute hepatitis is caused by naked or enveloped hepatitis viruses?

naked hepatitis A and E

24

chronic viral hepatitis is caused by naked or enveloped?

enveloped B,C,D

25

how is hepatitis B,C and D trasmitted?

through direct contact with blood

26

how is hepatitis A and E transmitted?

fecal-oral or food

27

hepatitis A virus belongs to what virus family?

picorna virus

28

what is hep A's biology?

naked single stranded +RNA

29

how many serotypes does hep A have?

1

30

how is hep A transmitted?

fecal-oral

31

what is the most common way to acquire hepatitis A?

consuming shellfish

32

if you are exposed to hepatitis A and acquire immunity, how long does that immunity last?

lifetime

33

what gives a definitive diagnosis of Hep A?

Hepatitis A IgM

34

what gives confirmation that a person is immune to hepatitis A?

IgG

35

how is hepaititis A treated?

not treated, do not give anti-virals

36

what prevention exists against hepatitis A? who is given this prevention?

inactivated virus vaccine for older that 1 y/o

37

how is hepatitis E transmitted?

fecal-oral

38

what is the most common way to acquire hepatitis E?

drinking contaminated water

39

where does hep. E replicate?

liver

40

what type of hepatitis does hep E cause?

mild acute hepatitis

41

hepatitis E infection in pregnant women is associated with what?

fulminant hepatitis

42

how is hepatitis E diagnosis confirmed?

antibodies against hepatitis E

ELISA

43

what ages are usually affected with hepatitis E?

all ages especially pregnant women

44

what ages are usually affected with hepatitis A?

young adults

45

what family does hepatitis C belong to?

flavi virus

46

what is the biology of hepatitis C?

enveloped single stranded +RNA

47

how is hepatitis C transmitted?

blood exposure (intravenous drug use, transplant and transfussions)

48

what is important about hepatitis C?

it is the most common cause of blood-born infections in US

49

what exacerbates the disease progression of hepatitis C?

alcohol

50

what can hepatitis C trigger?

cirrhosis

51

how do you diagnose hepatitis C?

anti-IgG hepatitis C virus

genotyping

qRT-PCR

52

what is used to monitor the antiviral therapy (interferon + ribavarin)?

hep C-RNA qRT-PCR

53

what hepatitis C genotypes have the worst prognosis?

genotypes 1 and 4

54

how is hepatitis C treated?

ribavarin and interferon