Double stranded RNA (Rotavirus + Norovirus) Flashcards Preview

Microbiology Block 1 > Double stranded RNA (Rotavirus + Norovirus) > Flashcards

Flashcards in Double stranded RNA (Rotavirus + Norovirus) Deck (21):
1

what is the biology of the rotavirus?

icosahedral dsRNA naked double capsid

2

how is rotavirus spread (transmitted)?

fecal-oral transmission

3

who gets rotavirus?

kids under 2 y/o

4

what is characteristic about the rotavirus serotype?

all serotypes based on VP7

5

 Rotavirus is the most common cause of what?

 severe diarrhea for children

6

what cells does rotavirus target? what will happen to those cells?

targets columnar epithelial cells that cover the villi of small intestine 

virus shortens microvilli and prevents absorption of water

7

what causes the diarrhea in rotavirus?

viral NSP4 protein acts as toxin 

8

what is the clinical presentation of rotavirus?

gastroenteritis - vomiting and watery diarrhea 

low fever, and abdominal pain

NO blood in stool or leukocytes

9

how can rotavirus cause death?

through hypovulemic shock  (not enough fluids in the body)

10

how do you treat rotavirus?

rehydration 

 

11

how is rotavirus prevented?

washing hands

 

12

are there vaccines against rotavirus? what are they?

yes

rotatrix (attenuated human rotavirus)

rotateq (VP7 pentavalent subunit)

13

what is the norovirus biology?

naked single straded positive RNA

14

is norovirus not resistant to stomach acids?

no, it can resist low pH

15

can norovirus be cultured?

no

16

who gets norovirus?

anyone more than 2 y/o

17

how is norovirus transmitted?

fecal-oral route

18

what is another name for norovirus?

norwalk

19

what is very important and characteristic of norovirus?

it is the most common cause of diarrhea in adults

20

what is the clinical presentation of norovirus?

diarrhea

vomiting

nausea

abdominal cramp

21

what cells are targeted by norwalk?

intestinal brush border , prevents water absorption