Anticancer Antibiotics Flashcards
Doxorubicin Mechanism
Inhibits Topisomerase II
Intercalates DNA
Block DNA/RNA Synthesis
Generate Free Radicals that damage DNA
Doxorubicin Use
Broad spectrum for solid, soft tissue, and hematopoietic
Doxorubicin Side Effects
Myelosuppressoin: neutropenia
Alopecia
Dilated Cardiomyopathy
-reversible: prevent: Dexrazoxone
Danorubicin Mechanism
Inhibits Topisomerase II
Intercalates DNA
Block DNA/RNA Synthesis
Generate Free Radicals that damage DNA
Danorubicin use
Broad spectrum for solid, soft tissue, and hematopoietic
Danorubicin Side Effects
Myelosuppressoin: neutropenia
Alopecia
Dilated Cardiomyopathy
-reversible: prevent: Dexrazoxone
Bleomycin mechanism
Small peptide: DNA & Iron binding regions
generates free radicals that damage DNA
Blocks G2-Phase
Bleomycin Use
Testicular cancer
HL
Bleomycin Side Effects
Hyperpigmentation
Pulmonary Fibrosis
alopecia
Raynaud’s
Dactinomycin (actinomycin D) Mechanism
intercalates into DNA: inhibits RNA replication
Dactinomycin (Actinomycin D) Use
Ewing Sarcoma
Wilms’ Tumor
Rhabdomyosarcoma
Dactinomycin (actinomycin D) Side Effects
Myelosuppression
Alopecia
N/V/D
Mucositis
Skin peeling: sun sensitivity
