Anticoagulants, Antiplatelets, Thromobolytics Flashcards Preview

Undeleted > Anticoagulants, Antiplatelets, Thromobolytics > Flashcards

Flashcards in Anticoagulants, Antiplatelets, Thromobolytics Deck (21):
1

thrombus formation

- break in the endothelial lining
- increased receptor activation
-- thromboxane
-- adenosine diphosphate

2

intrinsic pathway thrombus formation

damage to blood vessel

3

extrinsic pathway thrombus formation

damage to tissue outside vessel

4

anticoagulant indications: venous thromboembolic disease

- active DVT
- active PE
- prophylaxis of DVT

5

anticoagulant indications: arterial thromboembolic disease

- mechanical heart valves
- irregular heart rhythms
- transient ischemic attacks

6

anticoagulant indications: more

- maintenance of vascular grafts
- ICD
- prevent new clots (does NOT dissolve current clots)

7

PTT

Partial Thromboplastin Time

8

PTT: normal range

25 - 40 seconds

9

PTT: therapeutic range

55 - 70 seconds

10

PTT: protocol driven

4-6 hours commencing infusion
4-6 after changing dosing regimen

(but changes per hospital)

11

heparin-induced thrombocytopenia

HIT - allergy can be induced by heparin where antibodies attack platelets thus creating thrombocytopenia, platelets clump together are deactivated and are microemboli (think fingers and toes)

8% of patients develop antibody
1-5% patients on heparin develop thrombocytopenia

12

HIT treatment

- dc all heparin
- non-heparin based anticoag (EVERYWHERE - some IV lines and other devices have it embedded, beware)
- avoid platelet transfusions (makes embolic shower worse)

13

prothrombin time

?

14

international normalization ratio

ratio of patient clotting to the "normal" client
- weekly to monthly blood tests depending on what we're treating

15

international normalization ratio: normal

0.8 - 1.3

16

international normalization ratio: therapeutic

2 - 3 (want INR high, not normal)
sometimes 2.5 - 3.5

17

Lovenox and coumadin: significance

use Lovenox as bridge to therapy until coumadin reaches therapeutic levels but this is HELLA EXPENSIVE

18

coumadin reversal

FFP
Vitamin K: PO, SQ, IV, FOOD!!!!

19

Coumadin and Cefotetan significance

Cefotetan inhibits Vitamin K in gut!

EXTRA BLOODY

20

antiplatelet indications: prophylaxis

MI/coronary interventions
stroke
transischemic attack

21

antiplatelet: varying mechanisms

thromboxane (aspirin)
ADP
GII/IIIa

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