Antidepressants Flashcards Preview

PSYCH > Antidepressants > Flashcards

Flashcards in Antidepressants Deck (47):
1

What do monoamines do?q

NOT just refill actually..
synaptic plasticity
dendritic morphology
neurogenesis

2

first generation antidepressants

TCA, MAO-I

3

second generation antidep

SSRI, SNRI

4

5 serotonin SSRIs

citalopram
escitalopram
fluoxteine
paroxteine
fluvoxamine

5

serotonin TCA

clomlpramine

6

NE SNRI

venlafaxine
desvenlafaxine
duloxetine

7

NE TCA

nortyptillineimipramine
amitriptylline
desipramine

8

DA NDRI

bupropion

9

MAOI

phenelzine
tranylcipramine

10

citalopram mech of action

blocks 5ht reuptake transporter so 5ht stays in synase

can also block DA and NE reuptake by binding to 5HT R

11

citalopram also

bidnds to closely related 5HT receptors
histamine, DA, muscarinic (dryness), a and b adrenergic

12

where are 5HT receptors mostly?

raphe nucleus

13

side effects citalopram (celexa)

GI, sexual, sleep, sweating, Na_, mania

QT prolongation

14

venlafaxine side effects

GI, sexual, sleep, sweating, Na_, mania

diastolic blood pressure increase

15

why were tertiary amines bad?

they block Na+ channels in heart, so if you overdose you can get heart block, but secondary are better (all same but weaker side effects)

16

different between teritary (imipramine/amitriptyline) and secondary (desipramine/nortriptyline) amines

react more with 5HT than NE

17

tertiary amines work as

Class 1A anti-arhythmics

18

nortriptyline side effects

wt gain, sedation, Ach, hypotension, arrhythmia, sexual, sweating

19

nortriptyline is___in overdose

lethal

20

chlomipramine is

highly specific to 5HT, so its better for OCD

21

NDRI

NE-DA reuptake I
wellbutrin/bupropion

22

side effects wellbutrin

insomnia
tremor
tinnitus
seizures

23

how do MAOIs work?

suicide inhibitors; complelety kills enzyme; doesnt just block enzyme by occupying space, but gets rid of enzyme

24

even if you stop an MAOI

2 weeks until body makes new enzyme

25

Phenelzine (nardil)

developed as TB drug, sedating (MAOI)

26

tranylcypromine (parnate)

developed as amphetamine- stimulating

27

serotonin syndrome triad

MS seizures
autonomic instablility
neuromuscular signs

28

clinically, 5ht syndorme..

hypertensive crisis
seizure
stroke

29

hypertensive crisis

"cheese syndrome"
low tyramine diet needed (because tyramine is a precursor to D and NE)-->SS

30

NaSSA

dual reuptake
Mirtazapine (remeron)

31

do not combine Mirtazpine with

P450 drugs (other MAOIs)

32

side effects Mirtazpine

sedating, wt gain (histamine)

33

SARI

serotonin 2A antagonist dual reuptake
Nefazodone
trazodone
*can combine with P450 drugs

34

GABA drugs

benzodiazepines

35

what are benzos good for

sedative
anziolytic
seizure control
muscle relaxant
anterograde amnesia

36

benzos should never be

combined witha lcohol

37

benzos act as

positive allosteric modulator
--increase R affinity for endogenous GABA
--increase frequency of opening of CL channel when activated by GABA (and Cl makes resting potential more negative--higher activation energy)

38

Diazepam is...and binds tooo

nonselective
binds to all alpha R wherever they are in brain

39

side effects diazepam (valium)

sedation
depression
amnesa
ataxia
dependence
withdrawal

40

valium/diazepam is metabolized by the

liver

41

which benzo is renally cleared?

lorazapam

42

Zolpidem

alpha 2 selective BZD agonist
zolpidem
zalapion
eszopiclone

43

zolpidem binds

preferentially to a1 receptors

44

zolpidem is mostly for

sedation
forget what you did

45

Buspirone/BuSPar

5HT1A partial agonist
for GAD/Augment MDD

46

side effects buspirone

dizziness, sedation, nervous/restless

47

how long for buspirone to work

4 weeks, but no withdrawal after