Flashcards in Dementia Deck (15):
0
freq of 65+ year olds in 2030
1 in 5
dementia is an epidemic!
1
Major neurocognitive disorder
1 or more significant cognitive impairments
interfering with daily functioning
2
minor neurocognitive disorder
1 or more modest cognitive impairment
does not interefe with daily functioning
3
5 types of major neurocognitive disorder types
alzheimers
vascular disease
frontotemporal lobar degeneration
lewy body disease
parkinson's
4
6 cognitive domains
attention
executive function
memory
language
perceptual motor ability
social cognition
5
risk factors of alzheimers
age (primary--risk doubles veery 5 years after 65)
head trauma
low education
female
medial- CV risk factors
genetics
6
age 85
risk nearly 50%
7
genetics in alz
APPOE gene on E4 of 19 (late onset)
APP gene on chrom 21 (DS)
presenelin-1 on chrom 14
presenelin-2 on chrom 1 (early onset)
8
biology behind alz
accumulation of AB amyloid protein
to do this APP must be cut by two enzymes- beta and gama secretase
presenilin is responsible for this
9
ADLs vs iADLs
basic ADLs- primary function
iADLs are what is lost first and if you dont have them its ok
10
vascular disease
stepwise decline
executive fx and attention decline first
memory, mildly
11
frontotemporal lobar disease
change in behavior/personality
speech/language
cognitive
12
lewy body disease
COGNITIVE IMPAIRMENT
fluctuation in alertness
visual hallucinations
parkinsonism
13
AD meds
cholinesterase inhibitors
donepezil
rivastigmine
galantamine
mematine
14