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Flashcards in Dementia Deck (15):
0

freq of 65+ year olds in 2030

1 in 5
dementia is an epidemic!

1

Major neurocognitive disorder

1 or more significant cognitive impairments
interfering with daily functioning

2

minor neurocognitive disorder

1 or more modest cognitive impairment
does not interefe with daily functioning

3

5 types of major neurocognitive disorder types

alzheimers
vascular disease
frontotemporal lobar degeneration
lewy body disease
parkinson's

4

6 cognitive domains

attention
executive function
memory
language
perceptual motor ability
social cognition

5

risk factors of alzheimers

age (primary--risk doubles veery 5 years after 65)
head trauma
low education
female
medial- CV risk factors
genetics

6

age 85

risk nearly 50%

7

genetics in alz

APPOE gene on E4 of 19 (late onset)
APP gene on chrom 21 (DS)
presenelin-1 on chrom 14
presenelin-2 on chrom 1 (early onset)

8

biology behind alz

accumulation of AB amyloid protein
to do this APP must be cut by two enzymes- beta and gama secretase
presenilin is responsible for this

9

ADLs vs iADLs

basic ADLs- primary function
iADLs are what is lost first and if you dont have them its ok

10

vascular disease

stepwise decline
executive fx and attention decline first
memory, mildly

11

frontotemporal lobar disease

change in behavior/personality
speech/language
cognitive

12

lewy body disease

COGNITIVE IMPAIRMENT
fluctuation in alertness
visual hallucinations
parkinsonism

13

AD meds

cholinesterase inhibitors
donepezil
rivastigmine
galantamine
mematine

14

Pharm interventions

only slow down progression, but do NOT stop or reverse neurodegen (buys you 6-9 months)