Schizophrenia Flashcards Preview

PSYCH > Schizophrenia > Flashcards

Flashcards in Schizophrenia Deck (39):
1

neuro disregulation of schizophrenia

mesocorticolimbic circuit

2

must have 2 of 5 of these symptoms (and 1 from the first three)

delusions
hallucinations
disorganized speech
grossly disorganized or catatonic behaior
negative sxs

3

must also have

social/occupational dysfunction
duration of 6 months of continuous symptoms
no schizoaffective and mood disorder
no substance abuse or othe rmedical issue
need to exclude autism

4

relation to autism

autism has disorganized speech and negative symptoms, but does not have prominent hallucinations or delusions

5

somatic delusion

feet mechanical, device implanted

6

nihilistic delusion

world coming to an end

7

Schizophreniform Disorder

sitting on the tipping point to schizophrenia
duration of 1-6 months with a 50% chance of going on to develop schizophrenia

8

schizoaffective disorder

major depressive, manic, or mixed episodes concurrent with first criteria for schizo
--mood symptoms present for majority of total duration/delusions for 2+ weeks

9

subtypes of schizoaffective disorder

bipolar
depressive

10

delusional disorder

one or more delusions more than 1x month
criteria A not met
mood episodes brief compared to delusional periods

11

attenuated psychosis syndrome

intact reality testing- but either delusions, hallucinations, or disorganized speech
more than once/week for past month
suddenly distressing and disabling

12

schizo epi

1%

13

when does schizo begin?

typically teens

14

which episode is most responsive to treatment

first

15

how many relapses until chronic schizo?

3

16

women as compared to men

better premorbid function, estrogen is neuroprotective because inhibits D2 receptors

17

3 phases of schizo

1) prodromal
2) active
3) residual

18

prodromal phase

social, cognitive deficits may precede activity phase by many years

19

active phase

full syndrome, typically 3-4 decades (teens, 20s, 50s)

20

residual phase

1/3 remission, 1/3 attenuation of symptoms in older years, stages of illness propose

21

suicide in schizo

20-40% attempt, 10% complete

22

what med reduces risk of suicide and violence?

clozapine

23

life expectancy schizo

10-30 years

24

percentage of schizos that smoke

90%

25

what neuroanatomy fnding?

dendritic spine density on deep layer 3 pyramidal neurons
--means decrease excitability to DLPFC layer 3 pyramidal cells--> dec cognitive ability

26

functional brain abnormalities

diffuse cerebral dysfunction (esp prefrontal and medial temporal)

27

neurochemical brain abnormalities

DA hypersensitivity in MESOLIMBIC

DA hypoactivity in MESOCORTICAL

glutamate NMDA

5ht, GABA, NE, Ach

28

mesolimbic pathway

midbrain VTA-->Nucleus accumbens, olfactory tubercle, and limbic system

*overactivity due to postive symptoms

29

mesocortical pathway

midbrain VTA-->frontal cortex
*learning and memory; reduce associated with negative symptoms

30

nigostriatal pathway

control of movement

31

tuberoinfundibular pathway

projects from hypothalamus to anterior pituitary gland and controls prolactin secretion

32

if you treat the movement and prolactin pathway...

causes worsening of positive and negative symptoms

33

NMDA antagonists

causes apoptosis/neuro degen due to excitotoxicity

34

PCP and ketamine

neurodegen because they are NMDA antagonists

35

atypical antipsychotics

treat schizo because inhibit neurodegen assocaited with excitotoxicity and apoptosis

36

first generation antipsychotics

F2 antagonists (chlorpromazine, haloperidol)

37

second generational antipsychotics

clozapine
G2, 5HT2 antag

38

antipsychotics have limited improvement in

negative and cognitive symptoms

39

antispyschot drugs help

psychotic (positive) symptoms, agitation, disorganizaiton