Autism Spectrum Disorder Flashcards Preview

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Flashcards in Autism Spectrum Disorder Deck (39):
0

impairment in two domains

deficits in social communication/social interaction
restricted repetitive patterns of behavior, interests, and activities

1

DSM-5 Criteria for social communication

==>persistant deficit in social communication *need all three categories*

lack of social/emotional reciprocity
marked deficits in nonverbal and verbal communication used for social interaction
failure to develop and maintain peer relationships appropriate for developmental level

2

DSM5 Behavhior

repetitive, restricted patterns of behavior, interests, and activities as manifested by at least two-

stereotyped motor movements, use of objects or speech
insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal or nonverbal behaviors
highly restricted, fixated interests that are abnormal in intensity aor focus
hyper or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment

3

levels of autism

level 1- requiring support
level 2- requiring substantial support
level 3- requiring very substantial support

4

social communication disorder

new diagnosis in DSM 5
difficulties with social use of communication or language
NOT a variant of ASD- no restricted or repetitive patterns of behavior

5

prevalence of autism

occurs 1 out of 68 births

6

75% of people with autism are

mentally retarted

7

20% of people with autism

have a seizure disorder

8

gender ratio

boys:girls
5:1

9

increasd risk of autism with

increasing parental age
pre-term babies

10

1 child with ASD, leaves a what recurrence rate

20%

11

idential twins vs fratneral twins

70% identical twins
20% fraternal twins

12

neuro findings of autism

early brain overgrowth in first 2 years
differences in connectivity between frontal and parietal lobes

differences in empathy circuit

increased cerebral volume

13

diagnostic assesssmnet

no definitive diagnostic test

14

must first role out

hearing impairment, other psych disorders, eccentric/quirky behavior

15

different tests to confirm

MRI- focal neurologic signs
metabolic testing
genetic testing (DNA probe for fragile x, microarray, karyotype)
testing for mutations of PTEN gene (ASD and macrocephaly)
EEG

16

symptoms may

improve with time, but it is a lifelong progression

17

ASD and head circumference

25% of people have a head circumference in 97th percentile

18

ASG and _____ have mutations in the _____ gene, placing them at risk for _____

macrocephaly
PTEN
hamartomatous tumors

19

ADHD and ASD

45-59% of people

20

ADHD and employment

85% unemployed or under employed

21

pharmacology and ASD

treat specific symptoms with select medications

22

psychotropic meds

45% children and 75% adults
SSRIs, atypical antipsychotics, stimulants, clonidine, guanfacine

23

irritability

10-30%

24

Aberrant behavior checklist

irritability and agitation
lethargy and social withdrawal
sterotypic behavior
hyperactivity and noncompliance
inappropriate speech

25

first evaluate for

physical pain, dental pain, new stressors

26

FDA approved for irritability in autism

risperidone (wont eliminate completely)

27

antipsychotics are

last resort for ASD

28

kids and relapse on risperidone

yes

29

another fda approved drug for irritability in autism

aripiprazole

30

aripripazole vs risperidone

rispiridone- weight gain
aripip- not generic

31

mood stabilizers/adjunct to risperidone

topiramate
--decrease in sterotypic behavior (hyperactivity/noncompliance)

32

response rate in ADHD/ASD

less than normal kids

33

main side effect ADHD meds

irritability

34

first line adhd

stimulants

35

second line adhd

alpha 2 adrenergic agonists
atomoxetine

36

pharm for repetitive behavior

SSRIs- no different than placebo in kids (some work in adults)
aripiprazole and risperidone help but dnt help anxiety

37

SSRIs and family members

if first degree family member has a good response to SSRI, utilize one

38

drugs taht show promise for social impairment

oxytocine
d-cycloserine
arbaclofen