neuropsychatric sequelae Flashcards Preview

PSYCH > neuropsychatric sequelae > Flashcards

Flashcards in neuropsychatric sequelae Deck (37):
0

TBI

force acting on the brain that results in disturbance in level of consciousness (not necessarily loss of consciousness)

1

impact forces

contact with object

2

inertial forces

acceleration or deceleration of brain

3

distribution of diffuse axonal injury

subcortical white matter
corpus callosum

4

sequelae of DIA

axon is stretched
increased permeability
calcium influx
damage to cytoskeleton
impaired axoplasmic transport
axonal swelling
detachment and axonal death

5

primary injury

contusions
hemorrhages
DAI

6

secondary injury (evolves over time)

massive release of NT
cerebral edema/ischemia/hypoxia
increased intracranial pressure
subsequent traggering of excitotoxic injury cascades

7

parameters of assessing TBI

loss of consciousness
duration of post traumatic amnesia
glasgow coma scale score

8

percentage of mild TBI

70-80%

9

risk factors

gender- male
age- children under 4, individuals between 15-24, after 75
life tendencies
time- midafternoon, early evening, weekends, summer months

10

life tendencies

half of all traumatic brain injuries frm alcohol use
adhd/impulsivity

11

highest rates of TBI (age)

highest for people over 65

12

leading cause for people over 65

falls

13

leading cause for 5-24

motor vehicle crashes

14

ages 0-4

assualts

15

highest rates of ED visiss age

0-4 years

16

leading cause of TBI-ED visits/hospitalizations

falls

17

TDI disturbances

physical
cognitive
emotional/behavioral

18

neuropsychiatric disorder

about half of people who get TI

19

major categories of neuropsych sequeale- dysecutive syndromes

disorders of social comportment
disorders of motivation
disorders of executive cognition
psychiatric disorders

20

frontal subcortical circuits

dorsolateral prefrontal
lateral orbitofrontal
anterior cingulate

21

dorsolateral prefrontal

executive fx

22

lateral orbitofrontal

social intelligence

23

anterior cingulate

motivation

24

dysfunction in 1 frontal subcortical circuit

dysfunctionint hem all

25

most common cognitive complaint

memory (most common-working, short term, encoding)

26

dorsolaterla PFC

planning
set-shifting
problem solving
working memory

27

cognitive domains

complex attention
executive function
learning/memory
language
social cognition

28

pharamacologics fall under two categories

clinically studied
those showing promise in preclinical studies

29

clinically studied

statins
progesterone
cycosporine

30

statins

target excitotoxicity
apoptosis
inflammation
edema

31

progesterone

excitotoxicity
apoptosis
inflammation
edema
oxidative stress

32

SUR1-regulated NC channel inhibitors

apoptosis
edema
secondary hemorrhage
inflammation

33

cell cycle inhibitors

apoptosis
inflammation

34

PARP inhibitors

apoptosis inflammation

35

show promise in prelinical trials

diketopiperazines
substance P antagonists
SUR1-regulated NC channel inhibitors
cell cycle inhibitors
PARP inhibitors

36

guidelines for medical management

start low
go slow
stop sooner