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Flashcards in Pharm of Substance Abuse Deck (23):
1

Opium

fluid obtained from the poppy plant

2

Opiate

substance derived from opium

3

opiod

substance with morphine-like actions; synthetic or semi-synthetic

4

heroin is a

pro-drug-->6MAM-->MS
not bioavailable
rapidly penetrates BBB

5

Buprenorphin

partial opioid agonist-ceiling effect
low abuse potential
lower level physical dependence
less opioid effect as compared to methadone
safety in overdose quantities

6

suboxone has

poor bioavailability- sublingual

7

affinity

strength with which a drug physically binds to a receptor

8

Buprenorphine's affinity

very strong, will displace full agonists like heroin or methadone

NOT the same as receptor activation

9

dissociation

speed (slow or fast) of disengagement or uncoupling of a drug from the receptor

10

Bu's dissociation

slow- stays on for long time and blocks heroin/methadone's action

11

treatment for opiate overdose

narcan

12

classic triad of oopiate overdose

miosis
coma
resp depression

13

early opiate withdrawal

lacrimination
yawning
rhinorhea
sweating
anxiety/doom

14

middle phase opiate withdrawal

restless sleep
dilated pupils
anorexia
gooseflesh
irritability
tremor

15

late phase opiate withdrawal

increase in HR and BP
nausea, vomiting,
ab cramps
depression
weakness
bone pain

16

cocaine mech

blocks DA reuptake transported on presyn membrane -->therefore, increasing synaptic dopamine

17

amphetamine mech

enter DA neurons via reuptake transporters and interact intracellularly to release DA into presyn terminal

18

what does cocaine do

CNS stimulation
adrenergic effects
vasoconstrictive

19

prolonged use of cocaine

neuroadaptation- dec DAT dec Dop R

pulmonary effects from smoking

20

meth at high doses

hypomania
grandiosity
extreme insomnia
irritability

21

chronic MA leads to

reduction in DAT which leads to depletion of DA in presyn temrinas

22

crystal meth wtihdrawal

protracted abstinence syndrome
-depression, irritability, suicidal ideation

23

marijuana gets deposited

in fat tissue because lipid soluble