Intro To Substance Use Flashcards Preview

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Flashcards in Intro To Substance Use Deck (23):
1

opioid addiction postive and negative reinforcement

positive reinforcement: get eurphoria (high)
negative reinforcement: get withdrawal when wears off

2

Methadone

mu partial agonist

3

Buprenphine

Mu full agonist

4

three early theories of neurobio of schizo

dysregulated 5HT
dysreguated NE
hyperactive DA transmission

5

2 current models of schizo

neurodevelopmental
neurodegenerate

6

neurodevelopmental model

early abnormaity in utero, then around puberty development of hypofrontality which usually inhibits mesolimbic, so subsequent mesolimbic hyperactivity (Kindling Model)

7

neurodegenerate model

NMDA antagonists produce positive and negative symptoms and cognitive deficits

glutamatergic dysregulation leads to apoptosis

8

all first generation antipsychotics cause

extrapyramidal symptoms

9

4 typical antipsychotics (from low to high potency)

chlorpromazine
perphenazine
haloperidol (Haldol)
Fluphenazine (Prolixin)

10

typicla antipsychotics are

anti-cholinergics

11

diagnosis of neuroleptic malignant syndrome

major manifestations: fever, rigidity, elevated CPK

minor: abnormal bp, a;tered consciousness, tachypnea, altered conciousness, diaphoresis

3 major, or 2 major 4 minor

12

Clozapine

daramtically effective for positive and some negative symptoms

minimal EPS effects

minimal prolactin elevation

13

Clozapine mech of action

weak DA D2 receptor antagonism, but potent antagonist at 5HT and NE a2 R

14

worst side effects of clozapine

agranulocytosis
seizures
myocarditis

15

risperidone

first post-clozapine atypical antipsych

16

olanzapine

5HT/D2 R blockade
also has low EPS and low prolactin elevation

17

biggest side effect of olanzapine

weight gain, glucose/lipid dysregulation

18

Aripiprazole

partial DA agonist
minimal EPS, no prolactin elevation, low weight gain

functional antagonist under conditions of DA hyperactivity (pos symptoms)

functional agonist in conditions of DA hypoactivity (neg symptoms, cognitive)

19

What makes aripiprazole unique?

early activation

20

result of catie phase 2

clozapine is most effective

21

novel atypical antipsychotics

release of DA in PFC

22

D-cycloserine

partial agonist at glycine modulatory site
--+ typical antipsych-->decrease in neg symptoms
when added to cloz, no effect or increased symptoms

23

people are less likely to relapse on Cloz because

not dependent on D2 block