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Flashcards in Antimicrobials Deck (56)
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1

_______ have a bacteriostatic action, but are bactericidal in nature

Aminoglycosides

2

Antimicrobial: Favorable distribution into bone

Clindamycin

3

Antimicrobial: Favorable distribution into CSF

Ceftriaxone, Chloramphenicol, Metronidazole

4

Antimicrobial: Favorable distribution into gingival fluid

Tetracyclines

5

Antimicrobial: Favorable distribution into lungs

Macrolides

6

Antimicrobial: Favorable distribution into sebum

Tetracyclines

7

Antimicrobial: Favorable distribution into urine/kidneys

Aminoglycosides, Fluoroquinolones, Nitrofurantoin

8

Antimicrobial: Unfavorable distribution into a fetus

Aminoglycosides, Chloramphenicol, Tetracyclines, Fluoroquinolones, Metronidazole

9

Antimicrobial: Unfavorable distribution into bone

Tetracyclines

10

Antimicrobial: Unfavorable distribution into breast milk

Macrolides, Clindamycin

11

Antimicrobial: Unfavorable distribution into kidneys

Aminoglycosides

12

Antimicrobial: Unfavorable distribution into teeth

Tetracyclines

13

Bind and decrease absorption of cations, especially calcium

Fluoroquinolones, Tetracyclines

14

Examples of Fluoroquinolones (3)

Ciprofloxacin, Levofloxacin, Moxifloxacin

15

In bactericidal mechanisms MIC __ MBC

=

16

In bacteriostatic mechanisms MIC __ MBC

<<

17

Indications for bactericidal therapy (3)

Meningitis, Endocarditis, Suppressed/Deficient Immune System

18

Inhibitors of P450

Fluoroquinolones, Erythromycin, Clarithromycin

19

IV only antimicrobials (5)

Piperacillin/Tazobactam, Vancomycin, Ceftriaxone, Carbapenems, Aminoglycosides

20

Lowest concentration of antibiotic that kills 99.9% of the original inoculum

Minimum Bactericidal Concentration (MBC)

21

Lowest concentration of antibiotic that prevents visible bacterial growth

Minimum Inhibitory Concentration (MIC)

22

Mechanism of Action: Beta-lactamase inhibitor

Clavulanate, Tazobactam

23

Mechanism of Action: Decrease DNA function

Fluoroquinolones, Nitrofurantoin, Metronidazole

24

Mechanism of Action: Decrease protein synthesis

Macrolides, Tetracyclines, Clindamycin, Chloramphenicol, Aminoglycosides

25

Mechanism of Action: Inhibit Cell Wall Synthesis- Stage 2

Vancomycin

26

Mechanism of Action: Inhibit Cell Wall Synthesis- Stage 3 (Anti-pseudomonal)

Piperacillin/Tazobactam

27

Mechanism of Action: Inhibit Cell Wall Synthesis- Stage 3 (Extended Spectrum)

Amoxicillin +/- Clavulanate, Ampicillin

28

Mechanism of Action: Inhibit Cell Wall Synthesis- Stage 3 (penicillinase-resistant)

Dicloxacillin

29

Mechanism of Action: Inhibit Cell Wall Synthesis- Stage 3 (prototype, acid-stable)

Penicillin G, Penicillin V

30

Only obtain fluid cultures from drains or catheters if _____.

they are newly placed