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Flashcards in Inflammation Deck (111)
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1

______ are generated by intrinsic oxidases in ER of cells and in PMNs, also by radiation

Free radicals

2

______ chemically damage proteins, DNA, RNA, and trigger lipid peroxidation in cell membranes

Free radicals

3

2O2- + 2H+ -> H2O2 + O2- (catalyzed by ______)

superoxide dismutase

4

2ŸOH + 2GSH -> 2H2O + GSSG (catalyzed by _______)

glutathione peroxidase

5

Acute or chronic inflammation? Dilation and increased flow, increased permeability resulting in transudate or exudate

Acute

6

Acute or chronic inflammation? Duration of days

Acute

7

Acute or chronic inflammation? Onset over the course of days

Chronic

8

Acute or chronic inflammation? Sentinel/local cells in the tissue

Chronic

9

Acute phase cell(s)

Neutrophils

10

Cell adaptation: decrease in size and functional capacity of the cell

atrophy

11

Cell adaptation: increase in number of cells in a tissue

hyperplasia

12

Cell adaptation: increase in size of cell to enable increase in cell function

hypertrophy

13

Cell adaptation: replacement of one type of tissue with another in response to injury

metaplasia

14

Cell death by _____ tends to affect scattered, individual cells

apoptosis

15

Chemical species with an unpaired electron

Free radicals

16

Chronic phase cell(s)

Macrophages, lymphocytes, (eosinophils)

17

Eicosanoids are ________(pre-formed/synthesized on demand) and found in ________

on demand;WBCs, platelets, and endothelial cells

18

eNOS are ________(pre-formed/synthesized on demand) and found in ________

on demand; endothelial cells

19

Fe2+ + H2O2 -> Fe3+ + ŸOH + OH-

Fenton Reaction

20

Five cardinal signs of injury

redness, swelling, pain, heat, loss of function

21

Fragmentation of nuclei is also known as ______.

karyorrhexis

22

H2O2 -> O2 + 2H2O (catalyzed by ______)

Catalase

23

H2O2 + O2- -> ŸOH + OH- + O2

Haber-Weiss Reaction

24

Hagemen Factor activates _____ (3)

Thrombin/Coagulation pathway, plasmin, and Kallikrein pathway

25

Histamine is _________ (pre-formed/synthesized on demand)

pre-formed

26

Histamine is found in ________.

Platelets, mast cells, basophils

27

In ______, chromosomal DNA reflects nonspecific degradative smear of DNA fragments

necrosis

28

In hypoxia, _________ is proteolytically converted to xanthine _______, which produces oxygen radicals

xanthine dehydrogenase; oxidase

29

Inflammatory reaction characterized by accumulation of modified macrophages (epithelioid cells), giant cells, lymphocytes, and occasional plasma cells

Granulomatous infection

30

iNOS are ________(pre-formed/synthesized on demand) and found in ________

on demand; endothelial cells, macrophages, and smooth muscle