Anti-Inflammatory Pharmacology Flashcards Preview

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Flashcards in Anti-Inflammatory Pharmacology Deck (64)
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1

COX-__ is activated constitutively.

1

2

Acetaminophen is different from tNSAIDs in that it has no _______ effect

anti-inflammatory

3

Acetaminophen overdose can be treated with _______.

acetylcysteine

4

Alcoholic liver disease may be a contraindication for which drug?

acetaminophen

5

Aldosterone _______ reabsorption of sodium in the distal tubules of the kidney and _______ secretion of protons and potassium ions

increases; increases

6

Aspirin is different from tNSAIDs in that it has a ________ effect

anti-aggregatory

7

Aspirin is different from tNSAIDs pharmacodynamically in that it binds ________.

irreversibly

8

Cardiovascular disorders may be a contraindication for which drug?

celecoxib

9

Chronic renal insufficiency is a contraindication most significantly for which drug?

aspirin

10

Coagulation disorders are a contraindication for which drugs?

aspirin and tNSAIDs

11

COX-__ in platelets has a/an ___-coagulatory effect

1; pro

12

COX-___ in endothelial cells has aan ___-coagulatory

2; anti

13

GI irritation is a contraindication for which drugs?

aspirin and tNSAIDs

14

Glucocorticoids _____ production of mineralocorticoids, such as aldosterone

decrease

15

Glucocorticoids _____ vasodilation and ______ fluid exudation

decrease; decrease

16

Glucocorticoids ______ (induce/inhibit) COX-___.

inhibit; 2

17

Glucocorticoids ______ (induce/inhibit) lipocortins, which _____ (induce/inhibit) _______

induce; inhibit; Phospholipase A2

18

Glucocorticoids ______ accumulation and activation of inflammatory and immune cells

decrease

19

Glucocorticoids ______ healing and ______ immunoprotection

decrease; decrease

20

Greatest suppression of ACTH secretion at pituitary

Dexamethasone

21

Hypothalamic-pituitary-adrenal axis suppression occurs with extended use of _______.

glucocorticoids

22

In endothelial cells, COX-___ promotes vaso_____ and has ____-aggregatory effects

2; dilation; anti

23

In kidneys, COX-__ maintains renal blood flow, which is critical in the elderly and those with compromised renal function

2

24

In platelets, COX-__ has ___-aggregatory effects.

1; pro

25

In the ductus arteriosus, COX-___ the patent ductus arteriosus is maintained by vasodilation

2

26

In the GI tract, COX-___ _______ acid secretion, _______ mucous/bicarbonate production, has cytoprotective effects, and _______ smooth muscle contractions

1; decreases, increases, increases

27

In the hypothalamus, COX-___ is involved in fever production.

2

28

In the kidneys, COX-__ _____ renal blood flow and promotes diuresis

1; increases

29

In uterine smooth muscle, COX-___ promotes labor contractions.

2

30

In vascular smooth muscle, Cox-1 produces prostaglandins that promote vaso______ and thromboxanes that promote vaso_____.

dilation; constriction