Flashcards in Anti-Inflammatory Pharmacology Deck (64)
COX-__ is activated constitutively.
Acetaminophen is different from tNSAIDs in that it has no _______ effect
Acetaminophen overdose can be treated with _______.
Alcoholic liver disease may be a contraindication for which drug?
Aldosterone _______ reabsorption of sodium in the distal tubules of the kidney and _______ secretion of protons and potassium ions
Aspirin is different from tNSAIDs in that it has a ________ effect
Aspirin is different from tNSAIDs pharmacodynamically in that it binds ________.
Cardiovascular disorders may be a contraindication for which drug?
Chronic renal insufficiency is a contraindication most significantly for which drug?
Coagulation disorders are a contraindication for which drugs?
aspirin and tNSAIDs
COX-__ in platelets has a/an ___-coagulatory effect
COX-___ in endothelial cells has aan ___-coagulatory
GI irritation is a contraindication for which drugs?
aspirin and tNSAIDs
Glucocorticoids _____ production of mineralocorticoids, such as aldosterone
Glucocorticoids _____ vasodilation and ______ fluid exudation
Glucocorticoids ______ (induce/inhibit) COX-___.
Glucocorticoids ______ (induce/inhibit) lipocortins, which _____ (induce/inhibit) _______
induce; inhibit; Phospholipase A2
Glucocorticoids ______ accumulation and activation of inflammatory and immune cells
Glucocorticoids ______ healing and ______ immunoprotection
Greatest suppression of ACTH secretion at pituitary
Hypothalamic-pituitary-adrenal axis suppression occurs with extended use of _______.
In endothelial cells, COX-___ promotes vaso_____ and has ____-aggregatory effects
2; dilation; anti
In kidneys, COX-__ maintains renal blood flow, which is critical in the elderly and those with compromised renal function
In platelets, COX-__ has ___-aggregatory effects.
In the ductus arteriosus, COX-___ the patent ductus arteriosus is maintained by vasodilation
In the GI tract, COX-___ _______ acid secretion, _______ mucous/bicarbonate production, has cytoprotective effects, and _______ smooth muscle contractions
1; decreases, increases, increases
In the hypothalamus, COX-___ is involved in fever production.
In the kidneys, COX-__ _____ renal blood flow and promotes diuresis
In uterine smooth muscle, COX-___ promotes labor contractions.