Anti-Inflammatory Pharmacology Flashcards Preview

Disease and Defense > Anti-Inflammatory Pharmacology > Flashcards

Flashcards in Anti-Inflammatory Pharmacology Deck (64):
1

COX-__ is activated constitutively.

1

2

Acetaminophen is different from tNSAIDs in that it has no _______ effect

anti-inflammatory

3

Acetaminophen overdose can be treated with _______.

acetylcysteine

4

Alcoholic liver disease may be a contraindication for which drug?

acetaminophen

5

Aldosterone _______ reabsorption of sodium in the distal tubules of the kidney and _______ secretion of protons and potassium ions

increases; increases

6

Aspirin is different from tNSAIDs in that it has a ________ effect

anti-aggregatory

7

Aspirin is different from tNSAIDs pharmacodynamically in that it binds ________.

irreversibly

8

Cardiovascular disorders may be a contraindication for which drug?

celecoxib

9

Chronic renal insufficiency is a contraindication most significantly for which drug?

aspirin

10

Coagulation disorders are a contraindication for which drugs?

aspirin and tNSAIDs

11

COX-__ in platelets has a/an ___-coagulatory effect

1; pro

12

COX-___ in endothelial cells has aan ___-coagulatory

2; anti

13

GI irritation is a contraindication for which drugs?

aspirin and tNSAIDs

14

Glucocorticoids _____ production of mineralocorticoids, such as aldosterone

decrease

15

Glucocorticoids _____ vasodilation and ______ fluid exudation

decrease; decrease

16

Glucocorticoids ______ (induce/inhibit) COX-___.

inhibit; 2

17

Glucocorticoids ______ (induce/inhibit) lipocortins, which _____ (induce/inhibit) _______

induce; inhibit; Phospholipase A2

18

Glucocorticoids ______ accumulation and activation of inflammatory and immune cells

decrease

19

Glucocorticoids ______ healing and ______ immunoprotection

decrease; decrease

20

Greatest suppression of ACTH secretion at pituitary

Dexamethasone

21

Hypothalamic-pituitary-adrenal axis suppression occurs with extended use of _______.

glucocorticoids

22

In endothelial cells, COX-___ promotes vaso_____ and has ____-aggregatory effects

2; dilation; anti

23

In kidneys, COX-__ maintains renal blood flow, which is critical in the elderly and those with compromised renal function

2

24

In platelets, COX-__ has ___-aggregatory effects.

1; pro

25

In the ductus arteriosus, COX-___ the patent ductus arteriosus is maintained by vasodilation

2

26

In the GI tract, COX-___ _______ acid secretion, _______ mucous/bicarbonate production, has cytoprotective effects, and _______ smooth muscle contractions

1; decreases, increases, increases

27

In the hypothalamus, COX-___ is involved in fever production.

2

28

In the kidneys, COX-__ _____ renal blood flow and promotes diuresis

1; increases

29

In uterine smooth muscle, COX-___ promotes labor contractions.

2

30

In vascular smooth muscle, Cox-1 produces prostaglandins that promote vaso______ and thromboxanes that promote vaso_____.

dilation; constriction

31

Metabolic effect of glucocorticoids: ______ gluconeogenesis

increase

32

Metabolic effect of glucocorticoids: _______

increase

33

Metabolic effect of glucocorticoids: _______ amino acid uptake into liver and kidney

increase

34

Metabolic effect of glucocorticoids: _______ protein synthesis

decrease

35

Metabolic effect of glucocorticoids: _______ uptake of glucose by fat cells

decrease

36

Metabolic effect of glucocorticoids: transfer of amino acids from _______ to the ____

muscle and bone; liver

37

Most common oral agent for steroid burst therapy

prednisone

38

Most potent anti-inflammatory agent

dexamethasone

39

No anti-mineralocorticoid activity

triamcinolone and dexamethasone

40

Potent system agent with excellent topical activity

Triamcinolone

41

Pregnancy is a contraindication for which drugs?

aspirin, tNSAIDs, and celecoxib

42

Prostacyclin is important for vaso_____ and ___-aggregation

dilation; anti

43

Prostaglandin-related side effect: _______: COX-1 and COX-2 in kidney cells

renal dysfunction

44

Prostaglandin-related side effect: _______: COX-1 in gastric cells

ulceration and bleeding

45

Prostaglandin-related side effect: _______: COX-2 in endothelial cells

Increased thrombotic events

46

Prostaglandin-related side effect: _______: COX-2 in uterine smooth muscle

Delayed labor

47

Sulfa-allergies may be a contraindication for which drug?

celecoxib

48

Supratherapeutic acute doses of which drug can cause dizziness, excitement, and disorientation?

acetaminophen

49

The following symptoms suggest over dose of which drug? Headache, dizziness, diarrhea, tinnitus, visual disturbances, mental confusion, drowsiness, sweating, thirst, hyperventilation

aspirin

50

The following symptoms suggest over dose of which drug? vomiting, sweating fever, respiratory alkalosis, metabolic acidosis

aspirin

51

Therapy strategy that lessens growth-suppressive effect because anti-inflammatory actions last longer than suppressive effect on HPA axis

Alternate Day Therapy

52

Therapy strategy that minimizes rebound of disease; also uses to allow for recovery of HPA axis

Tapered Withdrawal

53

Thromboxane is important for vaso_____ and ____-aggregation

constriction; pro

54

Thromboxane-related side effect: _______: COX-1 in platelets

Increased bleeding risk

55

Use in children younger than 12 with viral infection is a contraindication for which drug?

aspirin

56

Used if parenteral administration is desired for steroid burst

methylprednisone

57

Which drug is safest for overdose: aspirin, tNSAIDs, or acetaminophen?

tNSAIDs

58

Which drugs can have bleeding as a side effect?

aspirin and tNSAIDs

59

Which drugs can have clotting as a side effect?

celecoxib

60

Which drugs can have GI upset as a side effect?

aspirin and tNSAIDs

61

Which drugs can have labor suppression as a side effect?

aspirin, tNSAIDs, and celecoxib

62

Which drugs can have renal dysfunction as a side effect?

aspirin, tNSAIDs, and celecoxib

63

Which drugs do not target COX-1?

Acetaminophen and Celecoxib

64

Which glucocorticoid agents can be administered topically?

hydrocortisone, triamcinolone, and dexamethasone