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Flashcards in Viruses Deck (73)
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1

______ period: No virus detectable inside or outside of cells (0-12 hours)

Eclipse

2

______ period: time from initiation of infection to release of new infectious particles from cells

Latent

3

______ viruses: hardier, can dry out, low pH, detergents, and high temperature

Naked

4

_______ viruses are more sensitive: susceptible to pH and environmental stressors; better transmitted by close contact

Enveloped

5

_______: continue to produce new virus over a long period of time

Persistent

6

_______: point mutations and genome shuffling to allow viruses to become unrecognizable to specific immune receptors

Antigenic variation

7

_______: virus genome is relatively silent, not replicating

Latent

8

_____: a virus is more likely to infect certain tissues and not others

Tropism

9

_____: virus proteins that resemble host proteins to escape recognition

molecular mimicry

10

____: mouse monoclonal antibody that is monoclonal anti-RSV

Palavisumab

11

Acute Local or Systemic? IgA and IgM antibodies produced

Systemic

12

Acute Local or Systemic? IgA antibody produced

Local

13

Acute Local or Systemic? Long duration of immunity

Systemic

14

Acute Local or Systemic? Primary or secondary viremia

Systemic

15

Acute Local or Systemic? Symptoms seen only at entry epithelium

Local

16

All RNA viruses have _______ that produces mRNA and replicates host genomes

RNA-dependent RNA polymerase (RdRp)

17

Antigenic ______: acquisition of a completely new gene segment

Shift

18

Antigenic _____: gradual change in a virus that occurs through a slow series of mutations, substitution, or deletions

Drift

19

Cells targeted for infection in CMV

Epithelia, monocytes, lymphocytes, others

20

Cells targeted for infection in HSV-1 and HSV-2

Mucosal epithelium

21

Cells targeted for infection in VZV

Mucosal epithelium

22

CMV incubation

2 weeks to 2 months

23

CMV is a ____ (genome) virus.

dsDNA

24

CMV Serology: IgM(-), IgG(-)

Never Infected

25

CMV Serology: IgM(-), IgG(+)

Previously Infected

26

CMV Serology: IgM(+), IgG(-)

Primary CMV infection

27

CMV Serology: IgM(+), IgG(+)

Recent CMV Activation

28

CMV transmission

Contact, blood transfusions, transplantations

29

Ebola is a ____ (genome) virus.

ssRNA

30

Ebola: _____: assembly, budding, nucleocapsid assembly, and immune defense

Matrix Protein VP24