Skin Neoplasms

Question 1

_____ (sex) are ____ times as likely to get basal cell carcinoma and _____ times as likely to get squamous cell carcinoma

Answer 1

Men; 2; 3

Question 2

_____ in an inhibitor of Smoothened used to treat _______

Answer 2

Vismodegib; Basal cell carcinoma

Question 3

_____ is an inhibitor of BRAF used to treat _______

Answer 3

Vemurafinib; melanoma

Question 4

______ nevi: dermal epidermal junction above the basement membrane zone of the epidermis

Answer 4

Junctional

Question 5

______ nevi: exclusively in the dermis

Answer 5

Intradermal

Question 6

______ nevi: irregular outline, variable pigmentation, indistinct borders, can be enlarged

Answer 6

Dysplastic

Question 7

______ nevi: melanocytes in dermal epidermal junction and within the dermis

Answer 7

Compound

Question 8

_______ Kaposi’s sarcoma: aggressive form in equatorial Africa, affects young men, rapidly fatal

Answer 8

lymphadenopathic

Question 9

_______ Kaposi’s sarcoma: elderly men of Eastern European descent

Answer 9

Classic

Question 10

_____: describes the degree of penetration into the skin in terms of physiologic levels

Answer 10

Clark level

Question 11

____: measurement of thickness in millimeters

Answer 11

Breslow depth

Question 12

Basal cell carcinoma results from a loss of function mutation in ______ with normally blocks ______.

Answer 12

PTCH1 (Patch 1); Smoothened (SMO)

Question 13

Endothelial cell neoplasms

Answer 13

Cherry angioma, hemangioma, port wine stain

Question 14

Fibroblast neoplasms

Answer 14

Dermatofibroma

Question 15

Melanocyte neoplasms (4)

Answer 15

Nevi, ephelides (freckles), lentigo, Café au lait macule

Question 16

Melanoma distribution for blacks, women, and men

Answer 16

Acral and mucosa; legs; back

Question 17

Melanoma results from mutations most commonly in _____ (50%) or _____ (20%)

Answer 17

BRAF; NRAS

Question 18

Most common malignancy in the US

Answer 18

Basal cell carcinoma

Question 19

Most important prognostic indicator in melanoma: ______

Answer 19

Breslow depth

Question 20

Sebacous gland neoplasms

Answer 20

Sebaceous hyperplasia, nevus sebaceous

Question 21

Smoking is a risk factor for _______ only

Answer 21

Squamous Cell Carcinoma

Question 22

Subtypes of Basal Cell Carcinoma (4)

Answer 22

Nodular, Superficial, Infiltrative, Sclerosing

Question 23

Subtypes of Melanoma (4)

Answer 23

Superficial spreading, Nodular; Lentigo Maligna; Acral lentiginous

Question 24

Subtypes of Squamous Cell Carcinoma (3)

Answer 24

Keratoacanthoma, infiltrative, in situ

Question 25

What pathology? Benign: most common on chest and back, also scalp, face, neck and extremities; papillary epidermal hyperplasia with proliferation of basal layer cells

Answer 25

Seborrheic keratoses

Question 26

What pathology? benign: primary truncal bright red smooth-topped papules

Answer 26

Cherry Angioma

Question 27

What pathology? Benign: yellow-white papule with central dell, distribution: face > trunk > extremities

Answer 27

Sebaceous hyperplasia

Question 28

What pathology? brown, firm papules most commonly on legs of adults, dimple sign of downward movement of tumor upon pinching

Answer 28

Dermatofibroma

Question 29

What pathology? dermal proliferation of capillary-sized endothelial cell-lined vessels, cells stain with placenta associated markers

Answer 29

Infantile Hemangioma

Question 30

What pathology? hamartoma that is a yellow-orange linear plaque with rapid growth at puberty

Answer 30

Nevus sebaceous

Question 31

What pathology? hyperkeratotic papule with variable size and thickness, typically found on chronically sun-damaged skin, metastasis most common in the lip

Answer 31

Squamous Cell Carcinoma

Question 32

What pathology? Malignant: flat, firm, pale areas or small raised pink/red translucent shiny waxy areas that may bleed after minor injury

Answer 32

Basal cell carcinoma

Question 33

What pathology? Malignant: nodule with central keratin plug

Answer 33

Keratoacanthoma

Question 34

What pathology? Most common benign tumor of childhood, vascular proliferations

Answer 34

Infantile Hemangioma

Question 35

What pathology? Most common premalignant lesion, hyperkeratosis and erythematous papules, risk for ________

Answer 35

Actinic keratoses; Squamous Cell Carcinoma

Question 36

What pathology? oval, slightly raised, light brown to black papules or plaques

Answer 36

Seborrheic keratoses

Question 37

What pathology? skin tag in areas of skin rubbing

Answer 37

Acrochordons

Question 38

What pathology? vascular malformations that do not resolve spontaneously

Answer 38

Port Wine Stain