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Flashcards in Skin Neoplasms Deck (38):
1

_____ (sex) are ____ times as likely to get basal cell carcinoma and _____ times as likely to get squamous cell carcinoma

Men; 2; 3

2

_____ in an inhibitor of Smoothened used to treat _______

Vismodegib; Basal cell carcinoma

3

_____ is an inhibitor of BRAF used to treat _______

Vemurafinib; melanoma

4

______ nevi: dermal epidermal junction above the basement membrane zone of the epidermis

Junctional

5

______ nevi: exclusively in the dermis

Intradermal

6

______ nevi: irregular outline, variable pigmentation, indistinct borders, can be enlarged

Dysplastic

7

______ nevi: melanocytes in dermal epidermal junction and within the dermis

Compound

8

_______ Kaposi's sarcoma: aggressive form in equatorial Africa, affects young men, rapidly fatal

lymphadenopathic

9

_______ Kaposi's sarcoma: elderly men of Eastern European descent

Classic

10

_____: describes the degree of penetration into the skin in terms of physiologic levels

Clark level

11

____: measurement of thickness in millimeters

Breslow depth

12

Basal cell carcinoma results from a loss of function mutation in ______ with normally blocks ______.

PTCH1 (Patch 1); Smoothened (SMO)

13

Endothelial cell neoplasms

Cherry angioma, hemangioma, port wine stain

14

Fibroblast neoplasms

Dermatofibroma

15

Melanocyte neoplasms (4)

Nevi, ephelides (freckles), lentigo, Café au lait macule

16

Melanoma distribution for blacks, women, and men

Acral and mucosa; legs; back

17

Melanoma results from mutations most commonly in _____ (50%) or _____ (20%)

BRAF; NRAS

18

Most common malignancy in the US

Basal cell carcinoma

19

Most important prognostic indicator in melanoma: ______

Breslow depth

20

Sebacous gland neoplasms

Sebaceous hyperplasia, nevus sebaceous

21

Smoking is a risk factor for _______ only

Squamous Cell Carcinoma

22

Subtypes of Basal Cell Carcinoma (4)

Nodular, Superficial, Infiltrative, Sclerosing

23

Subtypes of Melanoma (4)

Superficial spreading, Nodular; Lentigo Maligna; Acral lentiginous

24

Subtypes of Squamous Cell Carcinoma (3)

Keratoacanthoma, infiltrative, in situ

25

What pathology? Benign: most common on chest and back, also scalp, face, neck and extremities; papillary epidermal hyperplasia with proliferation of basal layer cells

Seborrheic keratoses

26

What pathology? benign: primary truncal bright red smooth-topped papules

Cherry Angioma

27

What pathology? Benign: yellow-white papule with central dell, distribution: face > trunk > extremities

Sebaceous hyperplasia

28

What pathology? brown, firm papules most commonly on legs of adults, dimple sign of downward movement of tumor upon pinching

Dermatofibroma

29

What pathology? dermal proliferation of capillary-sized endothelial cell-lined vessels, cells stain with placenta associated markers

Infantile Hemangioma

30

What pathology? hamartoma that is a yellow-orange linear plaque with rapid growth at puberty

Nevus sebaceous

31

What pathology? hyperkeratotic papule with variable size and thickness, typically found on chronically sun-damaged skin, metastasis most common in the lip

Squamous Cell Carcinoma

32

What pathology? Malignant: flat, firm, pale areas or small raised pink/red translucent shiny waxy areas that may bleed after minor injury

Basal cell carcinoma

33

What pathology? Malignant: nodule with central keratin plug

Keratoacanthoma

34

What pathology? Most common benign tumor of childhood, vascular proliferations

Infantile Hemangioma

35

What pathology? Most common premalignant lesion, hyperkeratosis and erythematous papules, risk for ________

Actinic keratoses; Squamous Cell Carcinoma

36

What pathology? oval, slightly raised, light brown to black papules or plaques

Seborrheic keratoses

37

What pathology? skin tag in areas of skin rubbing

Acrochordons

38

What pathology? vascular malformations that do not resolve spontaneously

Port Wine Stain