Antineoplastics 3 Flashcards Preview

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Flashcards in Antineoplastics 3 Deck (27)
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Microtubular function inhibitors/ antimitotics

Vincristine
Vinblastine
Paclitaxel

1

Blocks ability of tubulin to polymerize into microtubules

Vincristine
Vinblastine

2

Vincristine and Vinblastine metabolism

Liver, acetylation

3

Neurotox, polyneuropathies

Vincristine

4

Myelosuppression

Vinblastine

5

ALL, ewing, wilm, hodgkin's, brain tumors

Vincristine

6

Testicular, bladder carcinoma

Vinblastine

7

Microtubule overpolymerization, too stable

Paclitaxel

8

Hypersensitivity, neutropenia, peripheral neuropathy, nausea and vomiting uncommon

Paclitaxel

9

Ovarian CA, metastatic breast CA, small cell lung CA, squamous cell Ca of head and neck

Paclitaxel

10

Antibiotics/Intercalators

Dactinomycin
Doxorubicin
Daunorubicin
Bleomycin

11

Binds tightly to dna, inh both dna and rna synthesis, strand breakage, chromosome damage, more active in S and G2, does not enter csf, hepatic metab

Doxo and daunorubicin

12

Myelosuppression and cardiotoxicity

Doxorubicin
Daunorubicin

13

Aml

Daunorubicin

14

Binds to dna noncovalently, intercalation between guanine-cytosine base pairs with altered kinking

Dactinomycin

15

Inhibits dna pol and dna dependent rna pol, does not cross bbb

Dactinomycin

16

Stomatitis, oral ulcers, bone marrow depression

Dactinomycin

17

Water soluble glycopeptide antibiotics, dna intercalation and fe2+-_____-DNA complexes with production of oxygen free radicals

Bleomycin

18

Bleomycin most effective in what phases

G0 g2

19

Concentrates in tumor masses

Bleomycin

20

Pneumonitis and pulmonary fibrosis, myelosuppression minimal

Bleomycin

21

Hormonally directed agents

Prednisone
Tamoxifen
Flutamide

22

Lympholytic effects, able to suppress mitosis in lymphos, most combi therapies for leukemias

Prednisone

23

Antiestrogen competes with estradiol, hepatic metab, drug toxicity?

Hot flashes, vaginal bleeding, hypercalcemia

24

Antiestrogen

Tamoxifen

25

Pure antiandrogen, direct action on prostate cancer, competitive inhibition of testosterone

Flutamide

26

Fluid retention
Gynecomastia

Flutamide