Flashcards in Antineoplastics 3 Deck (27)
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Microtubular function inhibitors/ antimitotics
Vincristine
Vinblastine
Paclitaxel
1
Blocks ability of tubulin to polymerize into microtubules
Vincristine
Vinblastine
2
Vincristine and Vinblastine metabolism
Liver, acetylation
3
Neurotox, polyneuropathies
Vincristine
4
Myelosuppression
Vinblastine
5
ALL, ewing, wilm, hodgkin's, brain tumors
Vincristine
6
Testicular, bladder carcinoma
Vinblastine
7
Microtubule overpolymerization, too stable
Paclitaxel
8
Hypersensitivity, neutropenia, peripheral neuropathy, nausea and vomiting uncommon
Paclitaxel
9
Ovarian CA, metastatic breast CA, small cell lung CA, squamous cell Ca of head and neck
Paclitaxel
10
Antibiotics/Intercalators
Dactinomycin
Doxorubicin
Daunorubicin
Bleomycin
11
Binds tightly to dna, inh both dna and rna synthesis, strand breakage, chromosome damage, more active in S and G2, does not enter csf, hepatic metab
Doxo and daunorubicin
12
Myelosuppression and cardiotoxicity
Doxorubicin
Daunorubicin
13
Aml
Daunorubicin
14
Binds to dna noncovalently, intercalation between guanine-cytosine base pairs with altered kinking
Dactinomycin
15
Inhibits dna pol and dna dependent rna pol, does not cross bbb
Dactinomycin
16
Stomatitis, oral ulcers, bone marrow depression
Dactinomycin
17
Water soluble glycopeptide antibiotics, dna intercalation and fe2+-_____-DNA complexes with production of oxygen free radicals
Bleomycin
18
Bleomycin most effective in what phases
G0 g2
19
Concentrates in tumor masses
Bleomycin
20
Pneumonitis and pulmonary fibrosis, myelosuppression minimal
Bleomycin
21
Hormonally directed agents
Prednisone
Tamoxifen
Flutamide
22
Lympholytic effects, able to suppress mitosis in lymphos, most combi therapies for leukemias
Prednisone
23
Antiestrogen competes with estradiol, hepatic metab, drug toxicity?
Hot flashes, vaginal bleeding, hypercalcemia
24
Antiestrogen
Tamoxifen
25
Pure antiandrogen, direct action on prostate cancer, competitive inhibition of testosterone
Flutamide
26
