Antineoplastics 3

Question 0

Blocks ability of tubulin to polymerize into microtubules

Answer 0

Vincristine

Vinblastine

Question 1

Microtubular function inhibitors/ antimitotics

Answer 1

Vincristine
Vinblastine
Paclitaxel

Question 2

Vincristine and Vinblastine metabolism

Answer 2

Liver, acetylation

Question 3

Neurotox, polyneuropathies

Answer 3

Vincristine

Question 4

Myelosuppression

Answer 4

Vinblastine

Question 5

ALL, ewing, wilm, hodgkin’s, brain tumors

Answer 5

Vincristine

Question 6

Testicular, bladder carcinoma

Answer 6

Vinblastine

Question 7

Microtubule overpolymerization, too stable

Answer 7

Paclitaxel

Question 8

Hypersensitivity, neutropenia, peripheral neuropathy, nausea and vomiting uncommon

Answer 8

Paclitaxel

Question 9

Ovarian CA, metastatic breast CA, small cell lung CA, squamous cell Ca of head and neck

Answer 9

Paclitaxel

Question 10

Antibiotics/Intercalators

Answer 10

Dactinomycin
Doxorubicin
Daunorubicin
Bleomycin

Question 11

Binds tightly to dna, inh both dna and rna synthesis, strand breakage, chromosome damage, more active in S and G2, does not enter csf, hepatic metab

Answer 11

Doxo and daunorubicin

Question 12

Myelosuppression and cardiotoxicity

Answer 12

Doxorubicin

Daunorubicin

Question 13

Aml

Answer 13

Daunorubicin

Question 14

Binds to dna noncovalently, intercalation between guanine-cytosine base pairs with altered kinking

Answer 14

Dactinomycin

Question 15

Inhibits dna pol and dna dependent rna pol, does not cross bbb

Answer 15

Dactinomycin

Question 16

Stomatitis, oral ulcers, bone marrow depression

Answer 16

Dactinomycin

Question 17

Water soluble glycopeptide antibiotics, dna intercalation and fe2+-_____-DNA complexes with production of oxygen free radicals

Answer 17

Bleomycin

Question 18

Bleomycin most effective in what phases

Answer 18

G0 g2

Question 19

Concentrates in tumor masses

Answer 19

Bleomycin

Question 20

Pneumonitis and pulmonary fibrosis, myelosuppression minimal

Answer 20

Bleomycin

Question 21

Hormonally directed agents

Answer 21

Prednisone
Tamoxifen
Flutamide

Question 22

Lympholytic effects, able to suppress mitosis in lymphos, most combi therapies for leukemias

Answer 22

Prednisone

Question 23

Antiestrogen competes with estradiol, hepatic metab, drug toxicity?

Answer 23

Hot flashes, vaginal bleeding, hypercalcemia

Question 24

Antiestrogen

Answer 24

Tamoxifen

Question 25

Pure antiandrogen, direct action on prostate cancer, competitive inhibition of testosterone

Answer 25

Flutamide

Question 26

Fluid retention

Gynecomastia

Answer 26

Flutamide