Antineoplastics 2 Flashcards Preview

Ther 201 3rd Exam > Antineoplastics 2 > Flashcards

Flashcards in Antineoplastics 2 Deck (17)
Loading flashcards...
0

Specific carrier mediated, glutamyl residues impt for duaration of action

Methotrexate

1

Methotrexate cell cycle phase?

S phase, self limiting

2

Methotrexate antidote

Leucovorin

3

Bone marrow deppression
Oral and GI ulcerations
Pulmonary infiltrates and fibrosis

Methotrexate

4

Fluorine sub analog or uracil

5FU

5

5fu 5fdump blocks action of thymidilate synthetase, 5 utp incorporated into rna, not phase specific

5 fluorouracil

6

S specific antimetabolite, inhibits dna pol

Cytarabine

7

Ribose is replaced with ______, cytarabine

Arabinose

8

Inhibits adenylosuccinate synthetase and inosinate

Mercaptopurine

9

Bone marrow depression
Hyperuricemia

Mercaptopurine

10

Bone marrow depression
Sudden respiratory distress with high doses

Cytarabine

11

Bone marrow depression
Oral GI ulcerations
Severe diarrhea

5 fluorouracil

12

AML

Thioguanine
Cytarabine

13

ALL

Methotrexate (children)
Mercaptopurine

14

CML

Cytarabine
Mercaptopurine

15

Adenocarcinomas of GI tract, breast CA, premalignant skin hyperkeratosis, superficial bcca

Fluorouracil

16

Antimetabolites

Methotrexate
Fluorouracil
Cytarabine
Mercaptopurine
Thioguanine