Flashcards in Antineoplastics 2 Deck (17)
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Specific carrier mediated, glutamyl residues impt for duaration of action
Methotrexate
1
Methotrexate cell cycle phase?
S phase, self limiting
2
Methotrexate antidote
Leucovorin
3
Bone marrow deppression
Oral and GI ulcerations
Pulmonary infiltrates and fibrosis
Methotrexate
4
Fluorine sub analog or uracil
5FU
5
5fu 5fdump blocks action of thymidilate synthetase, 5 utp incorporated into rna, not phase specific
5 fluorouracil
6
S specific antimetabolite, inhibits dna pol
Cytarabine
7
Ribose is replaced with ______, cytarabine
Arabinose
8
Inhibits adenylosuccinate synthetase and inosinate
Mercaptopurine
9
Bone marrow depression
Hyperuricemia
Mercaptopurine
10
Bone marrow depression
Sudden respiratory distress with high doses
Cytarabine
11
Bone marrow depression
Oral GI ulcerations
Severe diarrhea
5 fluorouracil
12
AML
Thioguanine
Cytarabine
13
ALL
Methotrexate (children)
Mercaptopurine
14
CML
Cytarabine
Mercaptopurine
15
Adenocarcinomas of GI tract, breast CA, premalignant skin hyperkeratosis, superficial bcca
Fluorouracil
16
