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Ther 201 3rd Exam > Vaccines > Flashcards

Flashcards in Vaccines Deck (85)
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Induction of provision of immunity by any mean, active or passive

Immunization

1

Stimulation with antigen to develop immunologic defenses against a future exposure

Active immunization

2

Administration of preformed antibodies

Passive immunization

3

Occurs during infection

Natural active

4

Injecting or taking antigens by mouth

Artificial active

5

Mother to child placenta or milk

Natural passive

6

Injection of antitoxins given

Artificial passive

7

Results in the rapid appearance of low IgG antibody titers

Extrafollicular response

8

IgG titers peak after how many weeks?

4 weeks
2 weeks-4 weeks

9

Reactivates immune memory and results in a rapid <7 days increase of IgG antibody titer

Booster

10

Prevent or reduce infections by extra and intracellular agents and clear extracellular pathogens

Antibodies

11

Reduce control and clear (not prevent) intracellular pathogens

CD8+ cells

12

Reduce control and clear (do not prevent) extra and intra cellular pathogens

CD4+ cells

13

Antibody mechanisms

Binding to enzymatic and active sites of toxins
Opsonization
Complement activation
Preventing viral binding and entry

14

Antigens in vaccines

Weakened pathogens
Killed pathogens
Protein parts of pathogens

15

When a critical portion of the community is immunized against a contagious disease most members of the community are protected against the disease because there is little opportunity for an outbreak.

Community herd immunity

16

Critical portion

At least 80% immunized

17

Immune globulins

IVIg
Hep B immune globulin
Rabies immune globulin
Tetanus immune globulin
CMV immune globulin
Anti-D immune globulin (Rh)

18

Live attenuated vaccines

Viral mmr, varicella/zoster, yellow fever, rotavirus, intranasal influenza, vaccinia, oral polio

Bacterial BCG, oral typhoid

19

Weakened form of wild virus or bacteria, produces mild symptoms

Live attenuated

20

Cannot replicate, not as effective as live vaccines

Inactivated vaccines

21

Generally require 3-5 doses

Inactivated vaccines

22

Inactivated vaccine immune response

Mainly humoral

23

Boosters needed, titer may diminish with time

Inactivated

24

More durable immune response, which type of vaccine?

Live attenuated

25

Whole cell inactivated vaccines viral

Polio, hep a, rabies, influenza

26

Whole cell inactivated bacterial

Pertussis, typhoid, cholera, plague

27

Fractional inactivated

Subunit
Toxoid

28

Fragment of microbe, may be surface proteins or viral genes

Subunit

29

Examples of subunit vaccines

Hep B
Influenza
Acellular pertussis
Hpv
Anthrax