Vaccines

Question 0

Stimulation with antigen to develop immunologic defenses against a future exposure

Answer 0

Active immunization

Question 1

Induction of provision of immunity by any mean, active or passive

Answer 1

Immunization

Question 2

Administration of preformed antibodies

Answer 2

Passive immunization

Question 3

Occurs during infection

Answer 3

Natural active

Question 4

Injecting or taking antigens by mouth

Answer 4

Artificial active

Question 5

Mother to child placenta or milk

Answer 5

Natural passive

Question 6

Injection of antitoxins given

Answer 6

Artificial passive

Question 7

Results in the rapid appearance of low IgG antibody titers

Answer 7

Extrafollicular response

Question 8

IgG titers peak after how many weeks?

Answer 8

4 weeks

2 weeks-4 weeks

Question 9

Reactivates immune memory and results in a rapid <7 days increase of IgG antibody titer

Answer 9

Booster

Question 10

Prevent or reduce infections by extra and intracellular agents and clear extracellular pathogens

Answer 10

Antibodies

Question 11

Reduce control and clear (not prevent) intracellular pathogens

Answer 11

CD8+ cells

Question 12

Reduce control and clear (do not prevent) extra and intra cellular pathogens

Answer 12

CD4+ cells

Question 13

Antibody mechanisms

Answer 13

Binding to enzymatic and active sites of toxins
Opsonization
Complement activation
Preventing viral binding and entry

Question 14

Antigens in vaccines

Answer 14

Weakened pathogens
Killed pathogens
Protein parts of pathogens

Question 15

When a critical portion of the community is immunized against a contagious disease most members of the community are protected against the disease because there is little opportunity for an outbreak.

Answer 15

Community herd immunity

Question 16

Critical portion

Answer 16

At least 80% immunized

Question 17

Immune globulins

Answer 17

IVIg
Hep B immune globulin 
Rabies immune globulin 
Tetanus immune globulin 
CMV immune globulin 
Anti-D immune globulin (Rh)

Question 18

Live attenuated vaccines

Answer 18

Viral mmr, varicella/zoster, yellow fever, rotavirus, intranasal influenza, vaccinia, oral polio

Bacterial BCG, oral typhoid

Question 19

Weakened form of wild virus or bacteria, produces mild symptoms

Answer 19

Live attenuated

Question 20

Cannot replicate, not as effective as live vaccines

Answer 20

Inactivated vaccines

Question 21

Generally require 3-5 doses

Answer 21

Inactivated vaccines

Question 22

Inactivated vaccine immune response

Answer 22

Mainly humoral

Question 23

Boosters needed, titer may diminish with time

Answer 23

Inactivated

Question 24

More durable immune response, which type of vaccine?

Answer 24

Live attenuated

Question 25

Whole cell inactivated vaccines viral

Answer 25

Polio, hep a, rabies, influenza

Question 26

Whole cell inactivated bacterial

Answer 26

Pertussis, typhoid, cholera, plague

Question 27

Fractional inactivated

Answer 27

Subunit | Toxoid

Question 28

Fragment of microbe, may be surface proteins or viral genes

Answer 28

Subunit

Question 29

Examples of subunit vaccines

Answer 29

``` Hep B Influenza Acellular pertussis Hpv Anthrax ```

Question 30

Toxin rendered not harmful

Answer 30

Toxoid

Question 31

Toxoid examples

Answer 31

Diptheria | Tetanus

Question 32

Polysaccharide vaccines types

Answer 32

Pure polysaccharide | Conjugate polysaccharide

Question 33

Not consistently immunogenic in children <2 years

Answer 33

Pure Polysaccharide vaccines

Question 34

No booster response, antibody with less functional activity, immunogenicity improved by conjugation

Answer 34

Pure polysaccharide vaccines

Question 35

Examples pure polysaccharide

Answer 35

Pneumococcal | Meningococcal

Question 36

For children <2 years, linked to proteins

Answer 36

Conjugate polysaccharide

Question 37

Examples conjugate polysaccharide

Answer 37

H. influenzae type b Pneumococcal Meningococcal

Question 38

Bcg

Answer 38

Live attenuated

Question 39

Diptheria

Answer 39

Toxoid

Question 40

Tetanus

Answer 40

Toxoid

Question 41

Pertusis whole cell

Answer 41

Killed

Question 42

Pertussis acellular

Answer 42

Protein

Question 43

Polio Salk

Answer 43

Killed

Question 44

Polio Sabin

Answer 44

Live attenuated

Question 45

Rabies

Answer 45

Killed

Question 46

Hep A

Answer 46

Killed

Question 47

Hep B

Answer 47

Protein

Question 48

HPV

Answer 48

Fractional subunit, VLPs

Question 49

HiB

Answer 49

Polysaccharide

Question 50

HiB conjugate

Answer 50

Polysaccharide conjugate

Question 51

Pneumococcal

Answer 51

Polysaccharide | Conjugate

Question 52

Varicella

Answer 52

Live attenuated

Question 53

MMR

Answer 53

Live attenuated

Question 54

Typhoid

Answer 54

Live attenuated oral | Polysaccharide

Question 55

Influenza

Answer 55

Killed trivalent | Live attenuated intranasal

Question 56

Rotavirus

Answer 56

Live attenuated

Question 57

Meningococcal

Answer 57

Polysaccharide | Conjugate

Question 58

Yellow fever

Answer 58

Live attenuated

Question 59

WHO expanded program vaccines

Answer 59

``` BCG DPT OPV/Sabin HepB Measles (not MMR) ```

Question 60

Principles of vaccination

Answer 60

Correct Age Interval No. of doses

Question 61

Adverse reactions

Answer 61

Local pain swelling redness Systemic fever malaise headache Specific Allergic

Question 62

Local adverse reaction common in

Answer 62

Inactivated vaccines, tetanus hpv

Question 63

Systemic effects in

Answer 63

Live vaccines, dpt

Question 64

Intussuception

Answer 64

Rotavirus vaccine

Question 65

Permanent contraindications to vaccination

Answer 65

Severe allergic reaction to prior dose | Encephalopathy within 7 days of pertussis vaccination not due to other causes

Question 66

Allergy to component, live and inactivated

Answer 66

Contraindicated

Question 67

Encephalopathy, inactivated

Answer 67

Contraindicated

Question 68

Pregnancy, live

Answer 68

Contraindicated

Question 69

Pregnancy, inactivated

Answer 69

Vaccinate if indicated

Question 70

Immunosuppresion, live

Answer 70

Contraindicated

Question 71

Immunosuppression, inactivated

Answer 71

Vaccinate if indicated

Question 72

Severe illness, live and inactivated

Answer 72

Precaution

Question 73

Recent blood product, live

Answer 73

Precaution, mmr and varicella only 2 containing

Question 74

Recent blood product, inactivated

Answer 74

Vaccinate if indicated

Question 75

Routine adult immunization

Answer 75

``` Tetanus, diptheria, acellular pertussis HepB Varicella MMR Pneumococcal Influenza ```

Question 76

Additional vaccines for health care workers

Answer 76

Typhoid | Rabies

Question 77

DPT

Answer 77

Inactivated | Intramuscular

Question 78

HepB

Answer 78

Inactivated | IM

Question 79

Varicella

Answer 79

Live attenuated | SubQ

Question 80

MMR

Answer 80

Live attenuated | SubQ

Question 81

Pneumococcal

Answer 81

Inactivated | IM

Question 82

Influenza

Answer 82

Inactivated | IM

Question 83

Typhoid

Answer 83

IM capsular polysaccharide

Question 84

Rabies

Answer 84

IM/ ID