Flashcards in Antiparasitics 1 Deck (45)
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Giardia
Metronidazole
1
Amoebiasis
Diloxonide
Paramomycin
Metronidazole
2
Metronidazole moa
N group accepts e- from ferrodoxin of amoebic parasite
Reductive bioactivation produces cytotoxic products
React with protein and DNA
3
For severe amoebiasis, hepatic amoebic abscess, extraintestinal amoebiasis
Metronidazole
4
Can metronidazole penetrate the bbb?
Yes! Can be used to treat B fragilis brain abscess
5
First line drug for C difficle colitis
Metronidazole
6
Only aerobic bacteria that metronidazole can affect
Helicobacter pylori
7
Dry mouth with metallic taste, pancreatitis, ataxia, encephalopathy, seizures, dizziness, vertigo, disulfiram like reaction
Metronidazole
8
Metronidazole kind of drug
Nitromidazole
9
Diloxinide furoate can affect which stage of amoeba?
Before encystment
10
Entamoeba histolytica cyst, not active against trophozoites
Diloxonide
11
Malaria caused by 4 species of Plasmodium
Falciparum
Vivax
Ovale
Malariae
12
Most common plasmodium in the phil
Falciparum
13
2nd most common plasmodium in the phil
Vivax
14
Current P falciparum resistance profile in the phil
Artemether
Chloroquine
Fansidar
15
Most number of cases of malaria in the Philippines
Palawan
16
3 stages of Plasmodium cycle
Exo-erythrocytic
Erythrocytic
Sporogonic
17
Gut of mosquito
Sporogonic
18
Liver of human
Exo-erythrocytic
19
First line malaria treatment Philippines
Coartem
20
Only tissue schizontocide
Primaquine
21
Treatment regimen for uncomplicated vivax malaria
Day 0 and 1 CQ 150 mg, 10mg/kg/day, 4 tab/day
Day 2 CQ 150mg, 5mg/kg/day, 2 tab
Day 3 to 17 Primaquine, 15mg, 0.5mg/kg/d, 1 tab
22
Primaquine contraindicated in
Severe g6pd
23
Malaria prophylaxis drugs
Mefloquine
Doxycycline
24
Antibacterial 2nd line drugs for malaria
Tetracycline
Doxycycline
Clindamycin
25
Coartem
Artemether-lumefantrime
26
Very rapidly acting blood schizonticide against all malaria parasites, no effect on liver stage
Artemether
27
Artemether contraindicated for pregnant women?
NO!
28
Artemether metabolite
Dihydroartemisinin
29
