Antiparasitics 1 Flashcards Preview

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Flashcards in Antiparasitics 1 Deck (45)
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Giardia

Metronidazole

1

Amoebiasis

Diloxonide
Paramomycin
Metronidazole

2

Metronidazole moa

N group accepts e- from ferrodoxin of amoebic parasite
Reductive bioactivation produces cytotoxic products
React with protein and DNA

3

For severe amoebiasis, hepatic amoebic abscess, extraintestinal amoebiasis

Metronidazole

4

Can metronidazole penetrate the bbb?

Yes! Can be used to treat B fragilis brain abscess

5

First line drug for C difficle colitis

Metronidazole

6

Only aerobic bacteria that metronidazole can affect

Helicobacter pylori

7

Dry mouth with metallic taste, pancreatitis, ataxia, encephalopathy, seizures, dizziness, vertigo, disulfiram like reaction

Metronidazole

8

Metronidazole kind of drug

Nitromidazole

9

Diloxinide furoate can affect which stage of amoeba?

Before encystment

10

Entamoeba histolytica cyst, not active against trophozoites

Diloxonide

11

Malaria caused by 4 species of Plasmodium

Falciparum
Vivax
Ovale
Malariae

12

Most common plasmodium in the phil

Falciparum

13

2nd most common plasmodium in the phil

Vivax

14

Current P falciparum resistance profile in the phil

Artemether
Chloroquine
Fansidar

15

Most number of cases of malaria in the Philippines

Palawan

16

3 stages of Plasmodium cycle

Exo-erythrocytic
Erythrocytic
Sporogonic

17

Gut of mosquito

Sporogonic

18

Liver of human

Exo-erythrocytic

19

First line malaria treatment Philippines

Coartem

20

Only tissue schizontocide

Primaquine

21

Treatment regimen for uncomplicated vivax malaria

Day 0 and 1 CQ 150 mg, 10mg/kg/day, 4 tab/day

Day 2 CQ 150mg, 5mg/kg/day, 2 tab

Day 3 to 17 Primaquine, 15mg, 0.5mg/kg/d, 1 tab

22

Primaquine contraindicated in

Severe g6pd

23

Malaria prophylaxis drugs

Mefloquine
Doxycycline

24

Antibacterial 2nd line drugs for malaria

Tetracycline
Doxycycline
Clindamycin

25

Coartem

Artemether-lumefantrime

26

Very rapidly acting blood schizonticide against all malaria parasites, no effect on liver stage

Artemether

27

Artemether contraindicated for pregnant women?

NO!

28

Artemether metabolite

Dihydroartemisinin

29

Artemesia in the Philippines

Vulgaris