Flashcards in Antineoplastics 4 Deck (18)
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Enzymes and enzyme inhibitors
Asparaginase
Etoposide
1
Catalyzes hydrolysis of L-asparagine to asp acid and ammonia
Asparaginase
2
Hepatotox
CNS depression
Asparaginase
3
Most sensitive cells to asparaginase
Lymphoblasts in ALL
4
Antimitotic, delays transit of cells through s phase, arrest in late s or early g2
Etoposide
5
Bone marrow tox, podophyllin derivative
Etoposide
6
Testicular cancer, hodgkins, lung cancer
Etoposide
7
Stimulates dna topoisomerase ii to cleave dna
Etoposide
8
Monoclonal antibodies
Trastuzumab
Rituximab
Bevacizumab
Cetuximab
9
Downreg of HER2 receptor, dec angiogenesis
Trastuzumab
10
Against CD20 antigen
Rituximab
11
Antiangigenesis, attaches to and stops vegf, usually used with 5FU
Bevacizumab
12
Targets EGF, used with irinotecan
Cetuximab
13
Colorectal cancer
Cetuximab
14
Metastatic colorectal cancer
Bevacizumab
15
B cell non hodgkin lymphoma, post transplant lymphoma, CLL
Rituximab
16
Breast cancer
Trastuzumab
17
