Antineoplastics 4 Flashcards Preview

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Flashcards in Antineoplastics 4 Deck (18)
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Enzymes and enzyme inhibitors

Asparaginase
Etoposide

1

Catalyzes hydrolysis of L-asparagine to asp acid and ammonia

Asparaginase

2

Hepatotox
CNS depression

Asparaginase

3

Most sensitive cells to asparaginase

Lymphoblasts in ALL

4

Antimitotic, delays transit of cells through s phase, arrest in late s or early g2

Etoposide

5

Bone marrow tox, podophyllin derivative

Etoposide

6

Testicular cancer, hodgkins, lung cancer

Etoposide

7

Stimulates dna topoisomerase ii to cleave dna

Etoposide

8

Monoclonal antibodies

Trastuzumab
Rituximab
Bevacizumab
Cetuximab

9

Downreg of HER2 receptor, dec angiogenesis

Trastuzumab

10

Against CD20 antigen

Rituximab

11

Antiangigenesis, attaches to and stops vegf, usually used with 5FU

Bevacizumab

12

Targets EGF, used with irinotecan

Cetuximab

13

Colorectal cancer

Cetuximab

14

Metastatic colorectal cancer

Bevacizumab

15

B cell non hodgkin lymphoma, post transplant lymphoma, CLL

Rituximab

16

Breast cancer

Trastuzumab

17

Outcome of chemotherapy (5)

Tumor size
Tumor heterogeneity
Organs involved and location of tumor
Pharmacologic factors
Host factors