Antibacterials 5

Question 0

Sulfonamides structurally similar to

Answer 0

PABA

Question 1

Sulfonamides moa

Answer 1

Inhibitors of folate metabolism

Question 2

Sulfonamides are more soluble in alkaline pH?

Answer 2

Yes

Question 3

Prevents conversion of PABA and pteridine to dihydropteroic acid

Answer 3

Sulfonamides

Question 4

Prevents conversion of dihydrofolic acid to tetrahydrofolic acid

Answer 4

Trimethoprim

Question 5

Drug of choice for
Pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardosis

Answer 5

Cotrimoxazole

Question 6

Cotrimoxazole components

Answer 6

Trimethoprim

Sulfamethoxazole

Question 7

Bacteriostatic whentaken ind but bactericidal when taken together

Answer 7

Trimethoprim and sulfamethoxazole

Question 8

First line drug for typhoid fever

Answer 8

Cotrimoxazole

Question 9

Gram pos S aureus inc MRSA, S pyogenes, S pneumonia

Gram neg Haemophilus spp, E coli, Proteus mirabilis, Salmonella spp

Answer 9

Cotrimoxazole

Question 10

30S inhibitors

Answer 10

Aminoglycosides

Tetracyclines

Question 11

Reversible 30 S inhibitor

Answer 11

Tetracycline

Question 12

Irreversible 30S inhibitor

Answer 12

Aminoglycosides

Question 13

Aminoglycosides more active in what pH?

Answer 13

Alkaline

Question 14

Mycins?

Answer 14

Aminoglycosides

Question 15

Aminoglycosides synergistic with

Answer 15

Beta lactams

Question 16

Moa of Aminoglycosides

Answer 16

Interference with initiation complex
Breakup of polysome
Misreading mrna

Question 17

Ototoxic and nephrotoxic when continued at high doses for long periods

Answer 17

Aminoglycosides

Question 18

Most ototoxic agents, Aminoglycosides

Answer 18

Neomycin
Kanamycin
Amikacin

Question 19

Most nephrotoxic aminoglycosides

Answer 19

Neomycin
Tobramycin
Gentamicin

Question 20

Aminoglycoside, no activity for anaerobes

Answer 20

Gentamicin

Question 21

Can be administered intrathecally, aminogly

Answer 21

Gentamicin

Question 22

Acid stable 30s inhibitor

Answer 22

Tetracyclines

Question 23

Moa of tetracyclines

Answer 23

Blocks binding of aminoacyl-tRNA to acceptor site

Question 24

30S inhibitor with anaerobe activity

Answer 24

Tetracyclines

Question 25

Tetracycline resistance moa

Answer 25

Impaired influx, increased efflux Tet-AE Ribosome protection, interfere binding Tet-M Inactivation

Question 26

Absorption of tetracycline impaired by

Answer 26

Food Divalent cations Dairy products and antacids Alkaline pH

Question 27

Chelate with metals, dont administer with milk, antacids, ferrous sulfate

Answer 27

Tetracyclines

Question 28

Who should avoid tetracyclines?

Answer 28

Pregnant women | Children less than 8

Question 29

Drug of choice against rickettsiae

Answer 29

Tetracyclines

Question 30

Used in combination regimens to treat ulcers caused by H pylori

Answer 30

Tetracyclines

Question 31

IV injection can cause venous thrombosis

Answer 31

Tetracyclines

Question 32

Preferred for atypical microbes, Chlamydia, Mycoplasma

Answer 32

Doxycycline

Question 33

Elimination of doxy

Answer 33

Non renal

Question 34

Doxycycline admin

Answer 34

iV | Oral

Question 35

Chlamydia, mycoplasma pneumoniae, cholera, leptospirosis, malaria

Answer 35

Doxycycline

Question 36

50S inhibitors

Answer 36

Chloramphenicol Macrolides Clindamycin