Flashcards in Antibacterials 5 Deck (37)
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Sulfonamides moa
Inhibitors of folate metabolism
1
Sulfonamides structurally similar to
PABA
2
Sulfonamides are more soluble in alkaline pH?
Yes
3
Prevents conversion of PABA and pteridine to dihydropteroic acid
Sulfonamides
4
Prevents conversion of dihydrofolic acid to tetrahydrofolic acid
Trimethoprim
5
Drug of choice for
Pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardosis
Cotrimoxazole
6
Cotrimoxazole components
Trimethoprim
Sulfamethoxazole
7
Bacteriostatic whentaken ind but bactericidal when taken together
Trimethoprim and sulfamethoxazole
8
First line drug for typhoid fever
Cotrimoxazole
9
Gram pos S aureus inc MRSA, S pyogenes, S pneumonia
Gram neg Haemophilus spp, E coli, Proteus mirabilis, Salmonella spp
Cotrimoxazole
10
30S inhibitors
Aminoglycosides
Tetracyclines
11
Reversible 30 S inhibitor
Tetracycline
12
Irreversible 30S inhibitor
Aminoglycosides
13
Aminoglycosides more active in what pH?
Alkaline
14
Mycins?
Aminoglycosides
15
Aminoglycosides synergistic with
Beta lactams
16
Moa of Aminoglycosides
Interference with initiation complex
Breakup of polysome
Misreading mrna
17
Ototoxic and nephrotoxic when continued at high doses for long periods
Aminoglycosides
18
Most ototoxic agents, Aminoglycosides
Neomycin
Kanamycin
Amikacin
19
Most nephrotoxic aminoglycosides
Neomycin
Tobramycin
Gentamicin
20
Aminoglycoside, no activity for anaerobes
Gentamicin
21
Can be administered intrathecally, aminogly
Gentamicin
22
Acid stable 30s inhibitor
Tetracyclines
23
Moa of tetracyclines
Blocks binding of aminoacyl-tRNA to acceptor site
24
30S inhibitor with anaerobe activity
Tetracyclines
25
Tetracycline resistance moa
Impaired influx, increased efflux Tet-AE
Ribosome protection, interfere binding Tet-M
Inactivation
26
Absorption of tetracycline impaired by
Food
Divalent cations
Dairy products and antacids
Alkaline pH
27
Chelate with metals, dont administer with milk, antacids, ferrous sulfate
Tetracyclines
28
Who should avoid tetracyclines?
Pregnant women
Children less than 8
29
