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Ther 201 3rd Exam > Antibacterials 5 > Flashcards

Antibacterials 5 Flashcards

0
Q

Sulfonamides structurally similar to

A

PABA

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1
Q

Sulfonamides moa

A

Inhibitors of folate metabolism

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2
Q

Sulfonamides are more soluble in alkaline pH?

A

Yes

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3
Q

Prevents conversion of PABA and pteridine to dihydropteroic acid

A

Sulfonamides

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4
Q

Prevents conversion of dihydrofolic acid to tetrahydrofolic acid

A

Trimethoprim

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5
Q

Drug of choice for
Pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardosis

A

Cotrimoxazole

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6
Q

Cotrimoxazole components

A

Trimethoprim

Sulfamethoxazole

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7
Q

Bacteriostatic whentaken ind but bactericidal when taken together

A

Trimethoprim and sulfamethoxazole

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8
Q

First line drug for typhoid fever

A

Cotrimoxazole

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9
Q

Gram pos S aureus inc MRSA, S pyogenes, S pneumonia

Gram neg Haemophilus spp, E coli, Proteus mirabilis, Salmonella spp

A

Cotrimoxazole

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10
Q

30S inhibitors

A

Aminoglycosides

Tetracyclines

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11
Q

Reversible 30 S inhibitor

A

Tetracycline

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12
Q

Irreversible 30S inhibitor

A

Aminoglycosides

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13
Q

Aminoglycosides more active in what pH?

A

Alkaline

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14
Q

Mycins?

A

Aminoglycosides

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15
Q

Aminoglycosides synergistic with

A

Beta lactams

16
Q

Moa of Aminoglycosides

A

Interference with initiation complex
Breakup of polysome
Misreading mrna

17
Q

Ototoxic and nephrotoxic when continued at high doses for long periods

A

Aminoglycosides

18
Q

Most ototoxic agents, Aminoglycosides

A

Neomycin
Kanamycin
Amikacin

19
Q

Most nephrotoxic aminoglycosides

A

Neomycin
Tobramycin
Gentamicin

20
Q

Aminoglycoside, no activity for anaerobes

A

Gentamicin

21
Q

Can be administered intrathecally, aminogly

A

Gentamicin

22
Q

Acid stable 30s inhibitor

A

Tetracyclines

23
Q

Moa of tetracyclines

A

Blocks binding of aminoacyl-tRNA to acceptor site

24
Q

30S inhibitor with anaerobe activity

A

Tetracyclines

25
Q

Tetracycline resistance moa

A

Impaired influx, increased efflux Tet-AE
Ribosome protection, interfere binding Tet-M
Inactivation

26
Q

Absorption of tetracycline impaired by

A

Food
Divalent cations
Dairy products and antacids
Alkaline pH

27
Q

Chelate with metals, dont administer with milk, antacids, ferrous sulfate

A

Tetracyclines

28
Q

Who should avoid tetracyclines?

A

Pregnant women

Children less than 8

29
Q

Drug of choice against rickettsiae

A

Tetracyclines

30
Q

Used in combination regimens to treat ulcers caused by H pylori

A

Tetracyclines

31
Q

IV injection can cause venous thrombosis

A

Tetracyclines

32
Q

Preferred for atypical microbes, Chlamydia, Mycoplasma

A

Doxycycline

33
Q

Elimination of doxy

A

Non renal

34
Q

Doxycycline admin

A

iV

Oral

35
Q

Chlamydia, mycoplasma pneumoniae, cholera, leptospirosis, malaria

A

Doxycycline

36
Q

50S inhibitors

A

Chloramphenicol
Macrolides
Clindamycin

Ther 201 3rd Exam (16 decks)

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