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Flashcards in Antibacterials 5 Deck (37)
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Sulfonamides moa

Inhibitors of folate metabolism

1

Sulfonamides structurally similar to

PABA

2

Sulfonamides are more soluble in alkaline pH?

Yes

3

Prevents conversion of PABA and pteridine to dihydropteroic acid

Sulfonamides

4

Prevents conversion of dihydrofolic acid to tetrahydrofolic acid

Trimethoprim

5

Drug of choice for
Pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardosis

Cotrimoxazole

6

Cotrimoxazole components

Trimethoprim
Sulfamethoxazole

7

Bacteriostatic whentaken ind but bactericidal when taken together

Trimethoprim and sulfamethoxazole

8

First line drug for typhoid fever

Cotrimoxazole

9

Gram pos S aureus inc MRSA, S pyogenes, S pneumonia
Gram neg Haemophilus spp, E coli, Proteus mirabilis, Salmonella spp

Cotrimoxazole

10

30S inhibitors

Aminoglycosides
Tetracyclines

11

Reversible 30 S inhibitor

Tetracycline

12

Irreversible 30S inhibitor

Aminoglycosides

13

Aminoglycosides more active in what pH?

Alkaline

14

Mycins?

Aminoglycosides

15

Aminoglycosides synergistic with

Beta lactams

16

Moa of Aminoglycosides

Interference with initiation complex
Breakup of polysome
Misreading mrna

17

Ototoxic and nephrotoxic when continued at high doses for long periods

Aminoglycosides

18

Most ototoxic agents, Aminoglycosides

Neomycin
Kanamycin
Amikacin

19

Most nephrotoxic aminoglycosides

Neomycin
Tobramycin
Gentamicin

20

Aminoglycoside, no activity for anaerobes

Gentamicin

21

Can be administered intrathecally, aminogly

Gentamicin

22

Acid stable 30s inhibitor

Tetracyclines

23

Moa of tetracyclines

Blocks binding of aminoacyl-tRNA to acceptor site

24

30S inhibitor with anaerobe activity

Tetracyclines

25

Tetracycline resistance moa

Impaired influx, increased efflux Tet-AE
Ribosome protection, interfere binding Tet-M
Inactivation

26

Absorption of tetracycline impaired by

Food
Divalent cations
Dairy products and antacids
Alkaline pH

27

Chelate with metals, dont administer with milk, antacids, ferrous sulfate

Tetracyclines

28

Who should avoid tetracyclines?

Pregnant women
Children less than 8

29

Drug of choice against rickettsiae

Tetracyclines