Flashcards in Antibacterials 6 Deck (17)
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0
100 % oral bioavailability, 7% renally excreted
Chloramphenicol
1
50S inhibitors
Chloramphenicol
Macrolides
Clindamycin
2
Binds reversibly to 50s subunit, inhibits peptide bond formation, bacteriostatic broad spectrum, active against Rickettsiae not chlamydiae
Chloramphenicol
3
Cloramphenicol inactivation
Glucuronidation
Reduction to aryl amines
4
Oral formulation for bacterial meningitis for penicillin sensitive patients
Chloramphenicol
5
Topical for eye infection, typhus, Rocky Mountain spotted fever
Chloramphenicol
6
Adverse effect
Gray baby syndrome
Chloramphenicol
7
50S inhibitor that crosses the placenta and is present in breastmilk and CSF
Chloramphenicol
8
Macrocyclic lactone ring
Macrolides
9
Romycins
Macrolides
10
Blocks polypeptide exit tunnel
Erythromycin, macrolides
11
Special formulation of macrolides?
Enteric coating bec destroyed by stomach acid
12
50s inhibitor, lost in feces and bile
Erythromycin
13
Drug of choice in corynebacterial infections
Diptheria, sepsis, erythrasma
Erythromycin
14
Macrolide more active against M avium complex
Clarithromycin
15
Macrolide active against M avium, T gondii, H inf, Chlamydia, but less active against strep, staph
Azithromycin
16
