Antibacterials 6 Flashcards Preview

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Flashcards in Antibacterials 6 Deck (17)
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0

100 % oral bioavailability, 7% renally excreted

Chloramphenicol

1

50S inhibitors

Chloramphenicol
Macrolides
Clindamycin

2

Binds reversibly to 50s subunit, inhibits peptide bond formation, bacteriostatic broad spectrum, active against Rickettsiae not chlamydiae

Chloramphenicol

3

Cloramphenicol inactivation

Glucuronidation
Reduction to aryl amines

4

Oral formulation for bacterial meningitis for penicillin sensitive patients

Chloramphenicol

5

Topical for eye infection, typhus, Rocky Mountain spotted fever

Chloramphenicol

6

Adverse effect
Gray baby syndrome

Chloramphenicol

7

50S inhibitor that crosses the placenta and is present in breastmilk and CSF

Chloramphenicol

8

Macrocyclic lactone ring

Macrolides

9

Romycins

Macrolides

10

Blocks polypeptide exit tunnel

Erythromycin, macrolides

11

Special formulation of macrolides?

Enteric coating bec destroyed by stomach acid

12

50s inhibitor, lost in feces and bile

Erythromycin

13

Drug of choice in corynebacterial infections

Diptheria, sepsis, erythrasma

Erythromycin

14

Macrolide more active against M avium complex

Clarithromycin

15

Macrolide active against M avium, T gondii, H inf, Chlamydia, but less active against strep, staph

Azithromycin

16

Macrolide that does not inhibit cyp450

Azithromycin