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Flashcards in Arbo 1 Deck (60):
1

Bunya Family includes what genuses

Bunyavirus

Hantavirus

2

Families of Arbovirus

Bunya

Flavi

Toga

Reo

3

Flavivirus serotypes

SLE

Dengue

Yellow Fever

JEE

West Nile

4

Hantavirus serotype

Sin Nombre

5

Bunyavirus serotypes

California + Lacrosse

6

Togaviridae genuses

Rubella

Alphavirus

7

Alphavirus serotypes

EEE, WEE, VEE

8

Reoviridae genus and Serotypes

Rotavirus

Coltivirus (Serotype = Colorado Tick Fever Virus)

9

Two types of transmission cycles

Man > Arthropod > Man

Animal > Arthropod > Man

10

Arbovirus that displays BOTH transmission cycle types

Yellow Fever

11

Arboviruses that have Animal-Arthropod-Man cycle:

Japanese Encephalitis

WEE, EEE

Jungle Yellow fever

12

Arboviruses that show Man-Arthropod-Man cycle

Dengue

Urban Yellow Fever

13

Most arboviruses have what host

mosquito

14

Which Arboviruses have tick host

Colorado Tick Fever

15

Other animal reservoirs

Birds (JE, SLE, EEE, WEE)

Pigs (JE)

Monkeys (YF)

Rodents (VEE, Hantavirus)

16

___ and ___ cause hemorrhagic fever

yellow fever, dengue

17

Dx for arboviruses

Serology (USUALLY)

Culture

Direct detection tests

18

Bunyavirus human disease:

LaCrosse Encephalitis

19

Bunyavirus genus that we're concerned with

California Group (causes LaCrosse)

20

Bunyavirus structure

Enveloped Segmented (-)RNA

Helical capsid

21

Bunyavirus segments

L, M, S

22

Bunyavirus carries ____

Transcriptase

23

Most common cause of pediatric arboviral encephalitis

Bunyavirus

24

Arbovirus infects ______ system

Reticuloendothelial

25

_______ can block secondary viremia in arboviruses

Antibodies

26

Highest incidence of LaCrosse virus is in...

the midwest 

 

(Ohioooooo)

27

Major reservoir of LaCrosse (Bunya)

Chipmunks + Squirrels

28

LaCrosse Serology: When does antibody titer increase?

Between the acute and convalescent phases

29

Lacrosse virus has not been....

isolated from CSF

30

CSF characteristics for LaCrosse infection

Normal-ish ICP

Normal Glucose

Mildly high Protein

PMN Pleocytosis

31

LaCrosse Encephalitis Brain biopsy can show...

Perivascular infiltration with Mononuclear Cells

32

Bunyavirus Control and Treatment

No Treatment or vaccine

33

Hantavirus: 2 clinical presentations-

1. HPS = Hantavirus Pulmonary Syndrome (Sin Nombre) 

 

2. HFRS = Hemorrhagic Fever w Renal Syndrome*

*In Asia

 

34

HPS (Sin Nombre) characterized by a ____ followed by acute respiratory failure

febrile prodrome

35

HPS Symptom Stages

Early (flu like)

Late (Pulmonary)

36

HFRS initial symptoms

Head/Body ache

FEVER 

Nausea

Inflammation/ Redness of eyes

Rash

37

HFRS Later Symptoms

Low BP

Shock

Vascular leakage

ARF

38

Hantavirus primarily targets ______ cells after dissemination

Vascular Endothelial

 

esp. in heart, lung, lymph

39

Hantavirus causes __________ because of increased capillary permeability

protein-rich edema

 

(and Interstitial Pneumonitis of edema fluid, mononuclear cells, and lymph/leukocytes)

40

Hantavirus reservoir

Deer Mouse

41

Humans get infected by Hantavirus by what 3 ways?

inhalation of rodent waste

rodent bite

contact with excretion of rodent

42

Hantavirus Dx

Serology IgM and IgG

Immunochemistry

RT-PCR

43

Hantavirus Tx

Supportive care (Fluid, BP, O2)

44

Flaviviruses hosts

Broad range

45

Flavivirus genome/structure

Positive ssRNA (resembles mRNA)

Icosahedral

Enveloped

46

Flavivirus replicates in the ______, and is released by ______

cytoplasm, exocytosis

47

Flavivirus two general types of diseases:

  1. Encephalitis (SLE, JE, West Nile) 
  2. Hemorrhagic Fever (Dengue, Yellow Fever)

48

SLE incubation period

4-21 Days

49

SLE is a severe ____ disease that causes ________

neuroinvasive

encephalitis

50

SLE (Flavi) virus is produced (in body) in the ______, and then causes _______

Produced in site of innoculation

causes primary viremia

51

SLE is cleared from system by ________

reticuloendothelial system

52

Secondary viremia during SLE leads to ________

invasion of CNS

53

After healing from SLE, __________ occurs

Spongiform changes

54

SLE CSF examination shows 

mononuclear pleocytosis

Elevated protein

Normal Glucose

55

SLE lab Dx

Serum or CSF

to detect IgM and Antibodies

56

Japenese Encephalitis (JE) Stages

  1. Early - Fever, diarrhea, rigor  (and reduced consciousness)
  2. Later - Flaccid paralysis and Parkinsonian syndrome

57

Pahtogenesis of JE (5 steps)

  1. Mosquito bites
  2. Multiplication in RE system
  3. Viremia
  4. Transport to Brain
  5. Proliferation and damage 

58

JE hosts/vectors

Animals can act as hosts/intermediates

Humans are DEAD-END hosts

59

JE Treatment

None

60

JE vaccine

Who is it recommended for?

Purified formalin-inactivated vaccine  (3 doses)  

NOT RECOMMENDED FOR TRAVELERS