Intro Flashcards

(47 cards)

1
Q

Viruses genome type (general)

A

Either DNA or RNA (Not Both)

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2
Q

Virus organelles

A

None

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3
Q

Do viruses contain Muramic acid?

A

No

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4
Q

Do viruses have ribosomes?

A

No, mostly.Areanavuris packages ribosomes “accidentally”

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5
Q

Classical virus classification scheme based on what 4 properties?

A
  1. Genome type (size, strandedness, shape, +/-, segment)2. Symmetry3. Lipid membrane4. Virion/Capsid size
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6
Q

ICTV classification emphasizes what?

A

The viral genomeAlso based on viral structure (symmetry, icosahedral, helical, enveloped vs non-enveloped)

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7
Q

Baltimore classification

A

clusters into family based on the TYPE of genome*complement to ICTV

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8
Q

Baltimore DNA viruses

A

Groups 1 + 21. +/- dsDNA2. + ssDNA

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9
Q

Baltimore RNA viruses

A

Groups 3,4,53. +/- dsRNA4. + ssRNA5. - ssRNA

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10
Q

Which type of RNA virus is complimentary to RNA

A

-ssRNAIt has to create (+) strand to generate mRNA for protein synthesis

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11
Q

Copying of which strand of dsRNA will generate mRNA?

A

Negative (-) strand

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12
Q

Baltimore retroviruses

A

Groups 6 + 76. +ssRNA7. +/-dsDNA

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13
Q

RNA viruses typically have a _____ genome

A

Smallerdue to higher error rate

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14
Q

dsRNA viruses – two properties

A

One pieceSegmented

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15
Q

DNA viruses single or double stranded?

A

Both!

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16
Q

Virus genomes are ____ (referring to # of copies). Which virus is the exception?

A

HaploidRetroviruses (have two copies)

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17
Q

Capsid definition

A

Protein (VIRAL) shell surrounding the nucleic acid

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18
Q

Nucleocapsid made of…

A

Capsid + Nucleic Acid

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19
Q

Helical virus capsid is ______ and made of _________?

A

cylindrical made of capsomere surrounding the RNA

20
Q

Polyhedral virus capsid components

A

Capsomere and spikes

21
Q

Capsid made of ____ proteins

22
Q

Capsid is more or less stable than envelope?

23
Q

Capsid is stable to what things?

A
  1. Temp2. pH3. Proteases4. Detergents5. Drying
24
Q

Viral envelope composed of

A

Lipid, protein, glycoproteinMembrane from host, proteins from virus

25
All ____ have an envelope
Negative strand RNA viruses
26
Glycoproteins in envelope are for...
Viral attachment
27
Capsid viruses released by...
cell lysis
28
Enveloped viruses are released by...
either BUDDING or LYSIS
29
Which type of virus (capsid/enveloped) elicits hypersensitivity and inflammation?
EnvelopedThis causes immunopathogenesis
30
Naked capsid virus components
Nucleic AcidStructural ProteinEnzymes/NA-binding proteins =Nucleocapsid
31
Components of Enveloped virus
-Nucleocapsid (NA+Structural/Enzyme Proteins)-Glycoproteins -Membrane
32
DNA virus categories
-DS-SS Non enveloped-Complex Enveloped
33
Enveloped dsDNA Viruses
HerpesHepaDNA
34
Non-Enveloped dsDNA Viruses either...
Circular or Linear
35
Circular Non-Enveloped dsDNA
PapillomaPolyoma(formerly grouped together as PAPOVAviridae)
36
Linear Non-Enveloped dsDNA
Adeno
37
All DNA viruses are _______ except for \_\_\_\_\_\_\_
IcosahedralPoxviruses
38
RNA Virus categories
ss+ss-ds
39
RNA virus subcategories
\*\*draw the chart\*\*
40
Major viral replication steps (5)
1. Recognition / attachment2. Penetration / uncoating3. Synthesis of NA and protein -early mRNA synth --Replication ---Late mRNA synthesis ----Posttranslational Mod4. Assebly5. Budding (or Lysis)
41
Growth curve for virus from lysis is...
one step
42
Steps for one step growth curve
Adsorption/EntryUncoating and Replication (ECLIPSE)MaturationViral Release
43
During Eclipse period, what happens?
infectivity dissappears
44
What happens during latent period?
replication of NA and Protein
45
Attachment requires what process?
Recognition of receptor on host cell (for entry)
46
Non-Enveloped viruses penetrate by what methods?
Endocytosis (RME)Viropexis (direct)
47
Enveloped viruses penetrate by what methods?
Fusion (pH dependent)At Low pH -- Fusion occurs in ENDOSOMENormal pH -- Membrane fusion occurs at surface