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Flashcards in Intro Deck (47):
1

Viruses genome type (general)

Either DNA or RNA (Not Both)

2

Virus organelles

None

3

Do viruses contain Muramic acid?

No

4

Do viruses have ribosomes?

No, mostly.Areanavuris packages ribosomes "accidentally"

5

Classical virus classification scheme based on what 4 properties?

1. Genome type (size, strandedness, shape, +/-, segment)2. Symmetry3. Lipid membrane4. Virion/Capsid size

6

ICTV classification emphasizes what?

The viral genomeAlso based on viral structure (symmetry, icosahedral, helical, enveloped vs non-enveloped)

7

Baltimore classification

clusters into family based on the TYPE of genome*complement to ICTV

8

Baltimore DNA viruses

Groups 1 + 21. +/- dsDNA2. + ssDNA

9

Baltimore RNA viruses

Groups 3,4,53. +/- dsRNA4. + ssRNA5. - ssRNA

10

Which type of RNA virus is complimentary to RNA

-ssRNAIt has to create (+) strand to generate mRNA for protein synthesis

11

Copying of which strand of dsRNA will generate mRNA?

Negative (-) strand

12

Baltimore retroviruses

Groups 6 + 76. +ssRNA7. +/-dsDNA

13

RNA viruses typically have a _____ genome

Smallerdue to higher error rate

14

dsRNA viruses -- two properties

One pieceSegmented

15

DNA viruses single or double stranded?

Both!

16

Virus genomes are ____ (referring to # of copies). Which virus is the exception?

HaploidRetroviruses (have two copies)

17

Capsid definition

Protein (VIRAL) shell surrounding the nucleic acid

18

Nucleocapsid made of...

Capsid + Nucleic Acid

19

Helical virus capsid is ______ and made of _________?

cylindrical made of capsomere surrounding the RNA

20

Polyhedral virus capsid components

Capsomere and spikes

21

Capsid made of ____ proteins

Viral

22

Capsid is more or less stable than envelope?

More!

23

Capsid is stable to what things?

1. Temp2. pH3. Proteases4. Detergents5. Drying

24

Viral envelope composed of

Lipid, protein, glycoproteinMembrane from host, proteins from virus

25

All ____ have an envelope

Negative strand RNA viruses

26

Glycoproteins in envelope are for...

Viral attachment

27

Capsid viruses released by...

cell lysis

28

Enveloped viruses are released by...

either BUDDING or LYSIS

29

Which type of virus (capsid/enveloped) elicits hypersensitivity and inflammation?

EnvelopedThis causes immunopathogenesis

30

Naked capsid virus components

Nucleic AcidStructural ProteinEnzymes/NA-binding proteins =Nucleocapsid

31

Components of Enveloped virus

-Nucleocapsid (NA+Structural/Enzyme Proteins)-Glycoproteins -Membrane

32

DNA virus categories

-DS-SS Non enveloped-Complex Enveloped

33

Enveloped dsDNA Viruses

HerpesHepaDNA

34

Non-Enveloped dsDNA Viruses either...

Circular or Linear

35

Circular Non-Enveloped dsDNA

PapillomaPolyoma(formerly grouped together as PAPOVAviridae)

36

Linear Non-Enveloped dsDNA

Adeno

37

All DNA viruses are _______ except for _______

IcosahedralPoxviruses

38

RNA Virus categories

ss+ss-ds

39

RNA virus subcategories

**draw the chart**

40

Major viral replication steps (5)

1. Recognition / attachment2. Penetration / uncoating3. Synthesis of NA and protein -early mRNA synth --Replication ---Late mRNA synthesis ----Posttranslational Mod4. Assebly5. Budding (or Lysis)

41

Growth curve for virus from lysis is...

one step

42

Steps for one step growth curve

Adsorption/EntryUncoating and Replication (ECLIPSE)MaturationViral Release

43

During Eclipse period, what happens?

infectivity dissappears

44

What happens during latent period?

replication of NA and Protein

45

Attachment requires what process?

Recognition of receptor on host cell (for entry)

46

Non-Enveloped viruses penetrate by what methods?

Endocytosis (RME)Viropexis (direct)

47

Enveloped viruses penetrate by what methods?

Fusion (pH dependent)At Low pH -- Fusion occurs in ENDOSOMENormal pH -- Membrane fusion occurs at surface