Paramyx 2 and Toga Flashcards Preview

Virology > Paramyx 2 and Toga > Flashcards

Flashcards in Paramyx 2 and Toga Deck (87):
1

Morbillivirus is in what family of virus?

Paramyxo

2

Morbillivirus causes what named disease?

Measles (Rubeola)

3

Morbillivirus hosts

Only humans

4

Morbillivirus genome and shape:

ss -RNA , helical

5

Envelope proteins of Morbillivirus

HA + Fusion (F)

6

How many subtypes of Morbillivirus are there? What does this mean regarding vaccinations/immunity?

One antigenic type.... This makes vax easy, and immunity permanent.

7

Morbillivirus lacks what envelope protein?

Neuraminidase

8

Morbillivirus : Viremia Y/N?

Yes, acute manifestations in lymph and resp.

9

Morbillivirus clinical characterization (two stages)

URT symptoms during Prodromal stage...... Maculopapular rash during eruptive stage.

10

Morbillivirus three C's during what stage?

Prodromal stage: Coryza, Cough, Conjunctivitis

11

Major Sign for Morbillivirus

Koplik spots (second molar oral mucosa)

12

Morbillivirus Rash pattern

Head 1st, Limbs 2nd............Erythematous-> Confluent........rash fades in the same sequence it appears

13

Koplik spots appear after _____ days

2-3

14

Morbillivirus fever y/n?

yes. 104

15

Atypical Morbillivirus forms in whom?

Patients with incomplete immunity d/t vaccination with the original killed-virus vaccine

16

Modified Morbillivirus severity?

Less severe. Exposed people given serum IG

17

Morbillivirus common complications:

Otitis Media, PMA, Croup (laryngotracheobronchitis), Exacerbation of TB.....(KERATITIS that can lead to blindness)

18

_____ was one of the main reasons for introducing Morbillivirus vaccination?

Encephalitis

19

2 Major rare complications of Morbillivirus

Encephalitis and SSPE (subacute sclerosing panencephalitis)

20

SSPE caused by _____ Morbillivirus

immune resistant

21

SSPE tends to occur...

YEARS after measles... incubation of 10.8 years

22

Other rare complications of Morbillivirus

a bunch of -itis's...........myocard/pericard, hep, append, ileocol.

23

Pregnancy complications of Morbillivirus

Pneumonitis, SSPE, hepatitis, but LOW PERINATAL transmission rates

24

Morbillivirus infectious time period?

4 days before and after RASH onset

25

_____ is key to Morbillivirus pathogenesis

Viremia

26

Viremia (s) locations

1- reticuloendothelial system........2- epithelial surface (conj, UT, CNS)

27

Morbillivirus first replicates in...

the RESP Tract and LYMPH nodes

28

Second Morbillivirus viremia does what?

disseminates virus to other systems after 5-7 days

29

Morbillivirus causes generalized _____

immunosuppression

30

Morbillivirus causes _____________________ with immunodeficient patients

fatal GIANT cell PNA

31

___ and ___ are most common complications of Morbillivirus

Ear infections and PNA

32

1 in 4 people in developing world die from _________ related to Morbillivirus.

malnutrition and Vit A deficiency. Leading cause of BLINDNESS in African children.

33

Morbillivirus Transmission

Airborne (respiratory)

34

Antibodies to Morbillivirus first appear when?

2 days after rash develops

35

Morbillivirus clinical diagnosis chiefly made from

Triad, Koplik spots, adn Cephalocaudal rash

36

Lab tests for Morbillivirus

CBC (leukopenia), LFT (TA levels high), IgG and IgM testing, RTPCR

37

Morbillivirus vaccine type

live attenuated MMR

38

Rubulavirus a.k.a

Mumps

39

Mumps genome

ss -RNA

40

Mumps host

humans only

41

Mumps serotypes

only one serotype -- lifelong immunity

42

Mumps incubation time

12-26 days

43

Mumps Major Sx

Swelling, FEVER, Jaw/neck pain, Fatigue

44

up to ___% of Mumps are asymptomatic

20%

45

Major mumps complications

Orchitis/Oophoritis

46

Orchitis is uncommon in...

boys under 10 years old

47

Oophoritis occurs in ___% of postpubertal females

7%

48

Orchitis occurs in up to ___% of postpubertal males

50%

49

Other Mumps complications (not orchitis/oophoritis)

Pancreatitis, Aseptic Meningitis, Encephalitis (w permanent CNS problems)

50

Most specific indicator of pancreas involvement in Mumps is _______

Lipase levels

51

Mumps locally replicates in ______

Nasopharynx and regional lymph nodes

52

Mumps viremia established after how long?

12-25 days

53

Mumps virus disseminates from upper airway during ______

Viremia

54

Mumps viremia leads to ______ infection

systemic

55

Mumps transmission

Person to person, respiratory droplets, fomites

56

Mumps season

Late winter-spring

57

Mumps infectious period

3 days before, 9 days after onset

58

Mumps treatment

none

59

Mumps vaccine schedule

First dose as MMR @ 12 months or olde........ Second dose for school-aged kids or high exposure individuals

60

Togaviridae includes what viruses?

Rubella + Alphavirus

61

Rubella genome:

ss+RNA

62

Rubella shape

icosahedral

63

Rubella enveloped y/n?

yes

64

Rubella serotypes/variants?

only one

65

Rubella replication pattern

+RNA acts like mRNA and binds to ribosome. Translated to EARLY and LATE phases.

66

2/3 of Rubella genome translates....

one polypeptide that is cleaved into (NSP1-4) protease and RNA dependent RNApol

67

1/3 of Rubella genome translates...

Capsid and Envelope (E1-3) proteins

68

Rubella is aka

German Measles

69

Rubella is generally a _____ disease

mild

70

Serious version of Rubella is...

Congenital Rubella Syndrome - causes fetal death or defects

71

A Rubella infection may be transmitted from a ________ person

completely asymptomatic

72

Rubella incubation time

2-3 weeks

73

___ occurs in 50-80% of Rubella cases

Rash

74

Rubella's most characteristic clinical feature:

Swollen lymph glands behind the ears

75

Infected adults can develop ____ from Rubella

Arthritis

76

Conginital Rubella Syndrome ... ___ chance of passing on to fetus if infected early in pregnancy?

90%

77

Three conditions mentioned as being related to Congenital Rubella Syndrome

Autism, DM, Thyroid dysfunction

78

Rubella isn't really as much of a concern for...

males (because congenital is the bad one... only women can pass that one)

79

Three most common conditions caused by Congenital Rubella?

Hearing Loss, Patent Ductus Arteriosus, Cataract

80

Rubella, unlike other Togaviruses, is a ________

Respiratory virus

81

Rubella hosts

Humans only

82

Rubella spreads from nasopharynx to ____ & ____, which causes _____

Lymph nodes + Macrophage/Monocyte system....... causes viremia

83

Circulating Rubella antibody can block what

Primary and Secondary viremias, as well as vertical transmission through the placenta.... therefore IMMUNE DEFICIENT women can pass to fetus.

84

Rubella Dx Tests

IgG titre, Presence of Rubella specific IgM + rash = confirm diagnosis

85

Rubella vaccine

1. MMR 2. Tetravalent MMRV

86

_____ Rubella vaccine no longer available in US

Monovalent

87

MMR is given in...

two doses