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Flashcards in Paramyx 1 Deck (72):
1

Paramyxoviridae categories:

Paramyxovirus (Parainfluenza + Mumps), Morbillivirus (Measles), Pneumovirus (RSV)

2

Paramyxovirus genome classification

ss (-)RNA Helical

3

Paramyxovirus Enveloped or not?

Enveloped

4

Paramyxovirus capsid shape

helical

5

Paramyxoviridae replicate in....

cytoplasm

6

Paramyxoviridae cellular effects... and how?

Multinucleated giant cells....via F protein

7

Paramyxoviridae systemic effects

Cell Mediated Immunity (causes many Sx but is needed to control infection)

8

Measles family name

Morbillivirus

9

Viremia is caused by which paramyxoviridae?

Measles and Mumps cause viremia.

10

Which Paramyxoviridae do not cause viremia?

RSV and Parainfluenza

11

Paramyxovirus genome is associated with what proteins?

N protein

12

Paramyxovirus polymerase complex is formed by what?

L and P proteins

13

M protein (Paramyxovirus) does what?

Associates with envelope, organizes and maintains virion structure

14

The envelope of paramyxovirus contains _____

viral attachment glycoproteins (HN/F ---- H/F --- G/F)

15

Paramyxovirus sub family includes

Paramyxovirus, Rubulavirus, Morbillivirus

16

Pneumovirus subfamily

Pneumovirus, Metapneumovirus

17

Members of Paramyxovirus (sub)

HPIV 1, 2, 3, 4

18

Replication of HPIV occurs in the

Cytoplasm

19

Virion surface of HPIV contains ___ and ____ glycoproteins

fusion trimer & attachment tetramer

20

Paramyx -- Pneumovirus (genus) is what virus?

RSV

21

RSV is most common cause of

Fatal acute RTI in infants and young children

22

Re-infections of RSV possible?

Yes, throughout life

23

RSV hosts:

Humans only

24

RSV genome

ss -RNA

25

RSV capsid

Helical

26

Glycoproteins present in RSV?

F and G

27

RSV G protein doesn't have...

HA/NA activity

28

RSV is an important cause of viral _____ and primary ______ in young children.

LRTI ----- Primary bronchiolitis

29

RSV incidence peaks at

2-8 months

30

RSV bronchiolitis is usually _______

self limiting

31

In kids older than three, RSV infection is...

limited to URT

32

RSV atients who have chronic immunosuppression are at risk for...

Pneumonia (LRT disease)

33

RSV incubation period

3-6 days

34

RSV replicates in _____ and spreads to ______

URT, LRT

35

RSV bronchiolitis is a result of..

host immune response

36

How long is newborn protected from RSV by mom's antibody?

NO PROTECTION by maternal antibody

37

RSV bronchiolitis is virus-induced....

necrosis of epithelium

38

RSV spreads from cell to cell in the URT, causes ____ formation

Syncitium formation

39

Incidence of RSV infection in children

Most children have had by age 4

40

High risk groups for RSV infection

Kids in daycare, crowds, multiple birth sets.... Premature babies, CHF, SCID disease patients are at risk for SERIOUS disease.

41

RSV strongly suspected in...

infants with LRT disease

42

RSV diagnostic tests

IF staining Antibody, ELISA, PCR..... ISOLATION of virus to see CYTOPATHIC effects

43

RSV antivirals

RIBAVIRIN (nebulizer) ......... PALIVIZUMAB (passive immunization, monthly IM inject)

44

Human parainfluenza virus is in what family?

paramyxovuris

45

PIV subgroups

1-4

46

PIV genome

ss -RNA

47

PIV genome segments?

Unsegmented

48

PIV enveloped or not?

Enveloped

49

PIV glycoproteins

Hemagglutinin-Neuraminidase [HN] for virus attachment, Fusion [F] protein (spikes), and Matrix [M] protein.

50

PIV capsid shape

helical

51

PIV causes ___ and ____ infections (anatomically)

URT and LRT

52

HPIV are also a cause of ______ infections (epid.)

community-acquired RTI's

53

Are HPIV reinfecitons possible?

yes, but they tend to be less severe, and involve the URT

54

HPIV causes this named condition?

Croup

55

Croup is usually caused by what virus subtypes?

HPIV 1, 2, 3

56

Major symptom of croup

inspiratory stridor

57

Which HPIV subgroups cause bronchiolitis

1-4 (all of them)....... 1 +3 are the most common

58

Which HPIV subgroups cause PNA? What share of total cases are caused by these?

1 + 3 are most common. (10% of outpatient cases).......

59

HPIV associated with ____ in elderly

secondary bacterial PNA

60

25% of ____ are due to HPIV (subgroups?)

tracheobronchitis (mostly 3)

61

_____ seems to be the most common HPIV that causes other infections

HPIV 3

62

HPIV2 causes _______ in immunocompromised patients

Giant Cell PNA

63

HPIV viremia is _____

its is RARE

64

After cell entry, HPIV damages ____ cells

ciliated

65

Incubation period for HPIV

1-7 days (one week)

66

Systemically, HPIV causes ____ to be made

Cytokines (IL-2, 6) (IFN-a, TNFa)

67

What is the pathophysiology behind croup?

IgE specific to HPIV causes HISTAMINE release in trachea, causing edema

68

HPIV continues to be excreted ____ days (from respiratory tract)

3-16 days

69

HPIV transmission routes

Direct contact, surfaces, and inhalation

70

HPIV can remain aerosolized for ____

over an hour

71

In children older than 5, what percentage have antibodies to HPIV?

90-100% for HPIV-3, 75% for HPIV-1+2

72

Which strains are biennial, which are annual

HPIV 1 biennial, HPIV2 is annual or biennial FALL outbreak, HPIV 3 is spring or early summer peak