Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Virology > Paramyx 1 > Flashcards

Paramyx 1 Flashcards

(72 cards)

Start Studying
1
Q

Paramyxoviridae categories:

A

Paramyxovirus (Parainfluenza + Mumps), Morbillivirus (Measles), Pneumovirus (RSV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Paramyxovirus genome classification

A

ss (-)RNA Helical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Paramyxovirus Enveloped or not?

A

Enveloped

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Paramyxovirus capsid shape

A

helical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Paramyxoviridae replicate in….

A

cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Paramyxoviridae cellular effects… and how?

A

Multinucleated giant cells….via F protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Paramyxoviridae systemic effects

A

Cell Mediated Immunity (causes many Sx but is needed to control infection)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Measles family name

A

Morbillivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Viremia is caused by which paramyxoviridae?

A

Measles and Mumps cause viremia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which Paramyxoviridae do not cause viremia?

A

RSV and Parainfluenza

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Paramyxovirus genome is associated with what proteins?

A

N protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Paramyxovirus polymerase complex is formed by what?

A

L and P proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

M protein (Paramyxovirus) does what?

A

Associates with envelope, organizes and maintains virion structure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The envelope of paramyxovirus contains _____

A

viral attachment glycoproteins (HN/F —- H/F — G/F)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Paramyxovirus sub family includes

A

Paramyxovirus, Rubulavirus, Morbillivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pneumovirus subfamily

A

Pneumovirus, Metapneumovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Members of Paramyxovirus (sub)

A

HPIV 1, 2, 3, 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Replication of HPIV occurs in the

A

Cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Virion surface of HPIV contains ___ and ____ glycoproteins

A

fusion trimer & attachment tetramer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Paramyx – Pneumovirus (genus) is what virus?

A

RSV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

RSV is most common cause of

A

Fatal acute RTI in infants and young children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Re-infections of RSV possible?

A

Yes, throughout life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

RSV hosts:

A

Humans only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

RSV genome

A

ss -RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
RSV capsid
Helical
26
Glycoproteins present in RSV?
F and G
27
RSV G protein doesn't have...
HA/NA activity
28
RSV is an important cause of viral _____ and primary ______ in young children.
LRTI ----- Primary bronchiolitis
29
RSV incidence peaks at
2-8 months
30
RSV bronchiolitis is usually \_\_\_\_\_\_\_
self limiting
31
In kids older than three, RSV infection is...
limited to URT
32
RSV atients who have chronic immunosuppression are at risk for...
Pneumonia (LRT disease)
33
RSV incubation period
3-6 days
34
RSV replicates in _____ and spreads to \_\_\_\_\_\_
URT, LRT
35
RSV bronchiolitis is a result of..
host immune response
36
How long is newborn protected from RSV by mom's antibody?
NO PROTECTION by maternal antibody
37
RSV bronchiolitis is virus-induced....
necrosis of epithelium
38
RSV spreads from cell to cell in the URT, causes ____ formation
Syncitium formation
39
Incidence of RSV infection in children
Most children have had by age 4
40
High risk groups for RSV infection
Kids in daycare, crowds, multiple birth sets.... Premature babies, CHF, SCID disease patients are at risk for SERIOUS disease.
41
RSV strongly suspected in...
infants with LRT disease
42
RSV diagnostic tests
IF staining Antibody, ELISA, PCR..... ISOLATION of virus to see CYTOPATHIC effects
43
RSV antivirals
RIBAVIRIN (nebulizer) ......... PALIVIZUMAB (passive immunization, monthly IM inject)
44
Human parainfluenza virus is in what family?
paramyxovuris
45
PIV subgroups
1-4
46
PIV genome
ss -RNA
47
PIV genome segments?
Unsegmented
48
PIV enveloped or not?
Enveloped
49
PIV glycoproteins
Hemagglutinin-Neuraminidase [HN] for virus attachment, Fusion [F] protein (spikes), and Matrix [M] protein.
50
PIV capsid shape
helical
51
PIV causes ___ and ____ infections (anatomically)
URT and LRT
52
HPIV are also a cause of ______ infections (epid.)
community-acquired RTI's
53
Are HPIV reinfecitons possible?
yes, but they tend to be less severe, and involve the URT
54
HPIV causes this named condition?
Croup
55
Croup is usually caused by what virus subtypes?
HPIV 1, 2, 3
56
Major symptom of croup
inspiratory stridor
57
Which HPIV subgroups cause bronchiolitis
1-4 (all of them)....... 1 +3 are the most common
58
Which HPIV subgroups cause PNA? What share of total cases are caused by these?
1 + 3 are most common. (10% of outpatient cases).......
59
HPIV associated with ____ in elderly
secondary bacterial PNA
60
25% of ____ are due to HPIV (subgroups?)
tracheobronchitis (mostly 3)
61
\_\_\_\_\_ seems to be the most common HPIV that causes other infections
HPIV 3
62
HPIV2 causes _______ in immunocompromised patients
Giant Cell PNA
63
HPIV viremia is \_\_\_\_\_
its is RARE
64
After cell entry, HPIV damages ____ cells
ciliated
65
Incubation period for HPIV
1-7 days (one week)
66
Systemically, HPIV causes ____ to be made
Cytokines (IL-2, 6) (IFN-a, TNFa)
67
What is the pathophysiology behind croup?
IgE specific to HPIV causes HISTAMINE release in trachea, causing edema
68
HPIV continues to be excreted ____ days (from respiratory tract)
3-16 days
69
HPIV transmission routes
Direct contact, surfaces, and inhalation
70
HPIV can remain aerosolized for \_\_\_\_
over an hour
71
In children older than 5, what percentage have antibodies to HPIV?
90-100% for HPIV-3, 75% for HPIV-1+2
72
Which strains are biennial, which are annual
HPIV 1 biennial, HPIV2 is annual or biennial FALL outbreak, HPIV 3 is spring or early summer peak

Virology (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions