Human Strain of Parvovirus
Parvovirus Enveloped y/n?
Parvovirus genome type
ssDNA, either + or -
Only one serotype
Parvovirus B19 replicates in...
MITOTICALLY ACTIVE CELLS!
Parvovirus prefers which cells?
Erythroid lineage cells
Parvovirus binds to RBC ____ antigen
P antigen (globoside)
Parvovirus is internalized to the cell via ____
Parvovirus _______ genome is delivered to the nucleus where its converted to ________ by GROWING cells
ssDNA (+/-) converted to dsDNA
Parvovirus assembly occurs in the _________
Parvovirus is released by _______
Parvovirus Clinical presentation (name)
5th disease/ Slapped-Cheek Disease
Parvovirus incubation time
Early (contagious), Late phase (rash...three stages)
Parvovirus late phase stages (3)
Rash on cheek....... Erythematous maculopapular rash on trunk and limbs........... highly variable stage lasting 1-3 weeks
Parvovirus in adults typically shows ____ involvement
joint (occurs in 80% of females)
Pregnancy complication of Parvovirus
Hydrops fetalis occurs because Parvovirus...
attacks reticulocytes which leads to anemia of the fetus and death
Infection in the ___ trimester with Parvovirus is associated with a ____% fetal loss
1st = 5-10%.......... 2nd = 12.5%
Hydrops fetalis is diagnosed via ______
Parvovirus anemia is a problem when patient develops _______. Who is at risk?
aplastic crisis. Patients with chronic hemolytic anemia or Sickle cell.
Aplastic crisis can happen in what time frame?
aersol, oral secretions, transplacental
Parvovirus establishes ____ infection
lytic .... & large viremia
Parvovirus causes ______ (type) of disease
biphasic: first from viremia (flu Sx and shedding).... second from immune response (due to immune complexes in blood)
Parvovirus seropositivity rates are ____ by 60 years old
Erythema infectiosum diagnosis is made via
Parvovirus definitive Dx made with...
Specific IgM + Detection of VIRAL DNA
No Antiviral or vaccine