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Flashcards in Parviviridae Deck (29):
1

Human Strain of Parvovirus

B19

2

Parvovirus Enveloped y/n?

No

3

Parvovirus genome type

ssDNA, either + or -

4

Parvovirus serotypes

Only one serotype

5

Parvovirus B19 replicates in...

MITOTICALLY ACTIVE CELLS!

6

Parvovirus prefers which cells?

Erythroid lineage cells

7

Parvovirus binds to RBC ____ antigen

P antigen (globoside)

8

Parvovirus is internalized to the cell via ____

encoded pits

9

Parvovirus _______ genome is delivered to the nucleus where its converted to ________ by GROWING cells

ssDNA (+/-) converted to dsDNA

10

Parvovirus assembly occurs in the _________

Nucleus

11

Parvovirus is released by _______

cell lysis

12

Parvovirus Clinical presentation (name)

5th disease/ Slapped-Cheek Disease

13

Parvovirus incubation time

one week

14

Parvovirus Phases

Early (contagious), Late phase (rash...three stages)

15

Parvovirus late phase stages (3)

Rash on cheek....... Erythematous maculopapular rash on trunk and limbs........... highly variable stage lasting 1-3 weeks

16

Parvovirus in adults typically shows ____ involvement

joint (occurs in 80% of females)

17

Pregnancy complication of Parvovirus

Hydrops fetalis

18

Hydrops fetalis occurs because Parvovirus...

attacks reticulocytes which leads to anemia of the fetus and death

19

Infection in the ___ trimester with Parvovirus is associated with a ____% fetal loss

1st = 5-10%.......... 2nd = 12.5%

20

Hydrops fetalis is diagnosed via ______

ultrasound

21

Parvovirus anemia is a problem when patient develops _______. Who is at risk?

aplastic crisis. Patients with chronic hemolytic anemia or Sickle cell.

22

Aplastic crisis can happen in what time frame?

7-10 days

23

Parvovirus tramsmission

aersol, oral secretions, transplacental

24

Parvovirus establishes ____ infection

lytic .... & large viremia

25

Parvovirus causes ______ (type) of disease

biphasic: first from viremia (flu Sx and shedding).... second from immune response (due to immune complexes in blood)

26

Parvovirus seropositivity rates are ____ by 60 years old

90%

27

Erythema infectiosum diagnosis is made via

clinical presentation

28

Parvovirus definitive Dx made with...

Specific IgM + Detection of VIRAL DNA

29

Parvovirus treatment

No Antiviral or vaccine