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Virology > Papilloma and Polyoma > Flashcards

Flashcards in Papilloma and Polyoma Deck (54):
1

Papillomavirus structure

dsDNA (Circular)

Nonenveloped

icosahedral capsid

2

Papillomavirus capsid proteins

 

L1 + L2

L1 = 80% of virion

L2 = Minor, makes up the rest

3

There are _____ types of Papillomavirus

100 types

 

*grouped into 16 groups (A-P)

4

Papillomavirus strains are classified as _____ or _____

 

high or low risk

5

Cervical cancer is consistent with HPV in _____% of cases

 

75%

6

Papillomavirus replication occurs in the _____ and assembly occurs in the ______

 

nucleus, nucleus

7

HPV replicates in ______ cells

 

differentiated skin cells

8

_____ genes stimulate HPV division and growth

 

Early genes

9

Based on TISSUE tropism, HPV's are classified into _____ or ______

cutaneous or mucosal

10

Cutaneous HPV caused by strains...

 

1, 2, 3, 4

11

Cutaneous HPV incubation time

 

3-4 months

12

Mucosal HPV known to cause...

 

Single oral papillomas

Laryngeal papillomas

13

Most common benign epithelial tumors of the oral cavity are...

Single Oral Papillomas (Mucosal HPV)

14

Single oral papillomas features (2)

occur at any age

rarely recur

15

Laryngeal papillomas are associated with strains ______ and ____

 

6 + 11

16

Which mucosal papillomas are likelier to recur?

Laryngeal papillomas

 

17

A-G warts are caused by

 

condylomata acuminata

18

90% of AGW's are associated with HPV___ and ____

 

6+11

19

HPV strains associated with infection of the female genital tract:

 

16, 18, 31, 45

20

85% of cervical carcinoma contains _______

integrated DNA from HPV

21

Explain oncogenesis in terms of cervical dysplasia and HPV

E6 +E7 are oncogenic, and normally inhibited by E1+E2

E2 is broken to promote DNA integration

6 + 7 are free to bind p53 + RB genes and INHIBIT them

22

Cells of the ________________ are invaded by HPV

 

basal layer of epidermis

23

HPV infections can result in two outcomes - what are they?

Latent or Lytic

24

Latent HPV phase can have ______ and last for ______

no Sx

Last from Months to Years

25

After HPV latency, what begins?

 

Production of :

  • DNA
  • Capsid
  • Particles

26

Expression of structural proteins and vegetative DNA synthesis is limited to

 

terminally differentiated epidermal cells

27

Morphologic changes of host cells from HPV infection is called ______

 

Koilocytosis

28

HPV viremia lasts how long?

 

HPV does NOT cause viremia!!

29

HPV proteins for virus assembly and release

 

L1, L2, E4

30

HPV proteins for cell proliferation and replication?

 

E1 - E7  (*but not E3)

31

Koilocyte appearance

 

Multinucleated,

Big, hyperchromatic nucleus with irregular outlines

Perinuclear halo

32

HPV transmitted on _____

fomites

33

______ may promote HPV transmission

asymptomatic shedding

34

Lab tests for HPV can detect ___, ___, or ____

 

virus Nucleic Acid

Viral Antigens

Koiloctyotic cells

35

HPV control

 

  • Podophyllin resin, podofilox lotion
  • Aldara cream (= immune response modifier, stimulate cytokines and interferon)
  • VACCINE

36

HPV vaccines

Gardasil and Cervarix

37

Gardasil contains recombinant ____________

 

VLP's of 6, 11, 16, 18

38

Guardasil protects against ____ strains of HPV, which cause 70% of Cervical neoplasias worldwide

 

16 + 18

39

Gardasil mechanism

Triggers antibody response that prevents infection from the included types

40

Gardasil dosing schedule

given in 3 doses

0, 2, 6 months

41

Polyomaviruses (viruses)

BK + JC

(SV40 [simian] and murine)

42

Polyomaviruses differences from papillomaviruses

smaller and less complex

replicate in:

  • Resp
  • urinary
  • CNS (JC only)

43

Polyomaviruses are activated in _______ patients

immunocompromised

 

(also pregnant patients, but no transmission to the fetus)

44

Two infections caused by BK virus:

 

  1. Ureteral stenosis (renal transplant pts)
  2. Hemorrhagic cystits (bone marrow transplant pts)

45

Main JC virus infection

Progressive Multifocal Leukoencephalopathy (PML)

*occurs in IC patients (e.g. AIDS)

46

JC virus infects _____ cells, which results in ....

Oligodendrocytes

multifocal demyelination of CNS

47

PML prognosis

1-4 months

48

Polyomaviruses are limited to _______ and _______

specific hosts + cell types

49

JC+BK enter the ________ and infect ________

Then enter the _______ with minimal effect

 

respiratory tract

lymphocytes

kidney

50

BK virus establishes _______ in kidney

 

latent infection

51

JC cirus establishes infection where?

 

kidneys, B cells, monocyte-lineage cells

52

After multiplication in the kidney, JC/BK cause ____________ , which either results in permanent latent kidney infection (in non-IC) or reactivation and progression (in IC pts).

 

causes transient secondary viremia

53

BK more likely to cause _____ infections,

JC may cause _____ infection

BK --> UTI

JC --> CNS

54

Polyomaviruses control/treatment

 

None