Flashcards in Autoimmunity and Systemic Lupus Erythematosus Deck (12):
There are two broad categories of autoimmune disorders: ________________.
organ-specific and systemic
Lupus can be either type ___ or ___.
Explain the mnemonic MDSOAPBRAIN.
It lists the symptoms of lupus (four are required for diagnosis): malar rash, discoid rash, serositis, oral ulcers, anti-nuclear antibodies, photosensitivity, blood (anemia) renal dysfunction, arthritis, immunocompromised, neurologic (seizures or psychosis)
What is the most common demographic for lupus patients?
Women (9:1), post-pubertal, child bearing, non-caucasian
The strongest genetic association with lupus is _______ and the second strongest is _______.
C4 null allele; HLA-DR4
Roughly 10% of lupus patients have ___________.
warm autoimmune hemolytic anemia
Anti-phospholipid antibody leads to ________ in SLE patients.
increased clotting, by a mechanism that is still poorly understood (because aPL acts against prothrombin activation)
Neurologic symptoms appear in ___ percent of SLE patients.
Renal involvement is present in _______ SLE patients.
In SLE, B cells are usually ________ and debris is _______.
defectively regulated; slow to be cleared; this results in persistent auto-immunity
Describe illicit help.
An antigen-presenting cell shows foreign antigen coupled to self antigen to a CD4 T cell; that T cell can then bind to an autoreactive B cell that is bound to the self part of the antigen.