Autoimmunity and Systemic Lupus Erythematosus Flashcards Preview

MS1 - Blood & Lymph > Autoimmunity and Systemic Lupus Erythematosus > Flashcards

Flashcards in Autoimmunity and Systemic Lupus Erythematosus Deck (12):
1

There are two broad categories of autoimmune disorders: ________________.

organ-specific and systemic

2

Lupus can be either type ___ or ___.

II; III

3

Explain the mnemonic MDSOAPBRAIN.

It lists the symptoms of lupus (four are required for diagnosis): malar rash, discoid rash, serositis, oral ulcers, anti-nuclear antibodies, photosensitivity, blood (anemia) renal dysfunction, arthritis, immunocompromised, neurologic (seizures or psychosis)

4

What is the most common demographic for lupus patients?

Women (9:1), post-pubertal, child bearing, non-caucasian

5

The strongest genetic association with lupus is _______ and the second strongest is _______.

C4 null allele; HLA-DR4

6

Roughly 10% of lupus patients have ___________.

warm autoimmune hemolytic anemia

7

Anti-phospholipid antibody leads to ________ in SLE patients.

increased clotting, by a mechanism that is still poorly understood (because aPL acts against prothrombin activation)

8

Neurologic symptoms appear in ___ percent of SLE patients.

66

9

Renal involvement is present in _______ SLE patients.

nearly all

10

In SLE, B cells are usually ________ and debris is _______.

defectively regulated; slow to be cleared; this results in persistent auto-immunity

11

Describe illicit help.

An antigen-presenting cell shows foreign antigen coupled to self antigen to a CD4 T cell; that T cell can then bind to an autoreactive B cell that is bound to the self part of the antigen.

12

Why are lupus patients anemic?

They have chronic inflammation (which decreases iron absorption and EPO production) and they make IgG to RBC and WBC surface antigens.

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