Flashcards in Bacterial Septicemias of pigs Deck (32)
What are two diseases that cause bacterial septicemias in pigs?
1. streptococcus suis
2. haemophilus parasuis
How many serotypes of strep suis are there?
What is the most common serotype of streptococcus suis?
Is type 2 streptococcus suis zoonotic?
What is the carrier state of streptococcus suis in sows?
What does streptococcus suis (mostly type 2) cause in people?
How are people infected with strep suis?
through skin wounds
What is the epidemiology of strep suis?
1. normal commensal (URT)
2. many species are reservoirs
3. long survival in environment
4. virulence varies with serotype
5. sow-piglet transmission
6. pig-pig transmission
How do sows transfer strep suis to their offspring?ritis, valvular endocarditis
via genital tract
What is the onset of disease with strep suis?
5-10wks (nursery, grower)
What are the clinical signs of strep suis?
1. peracute: found dead
2. acute: polyserositis, meningitis--neuro signs
3. chronic: arthritis, valvular endocarditis
What is the pathogenesis streptococcus suis meningitis?
1. invade BBB endothelial cells
3. leakiness of BBB
4. septic meningitis
5. leakage of plasma protein
6. cerebral edema
What is the pathology of strep suis meningitis?
protrusions of cerebral vermis
can sometimes see suppurative material ventrally
What is the pathogenesis of sepsis (strep suis?)
1. invasion of tonsil/nasal cavity
2. ineffective humoral immunity
3. bacteremia-->localization or release of inflam cytokines
4. septic shock
How is strep suis diagnosed?
1. convulsions, other signs
2. culture, serotyping
What is the most common cause of pleural adhesions and pericarditis on modern farms?
How is strep suis meningitis treated and controlled?
1. prompt recognition
3. parenteral anti-inflammatories (predef)
How is strep suis sepsis treated and controlled?
1. mass antimicrobial
2. control precipitating stress
Is vaccination effective for contorl of strep suis sepsis?
NO. do not produce sufficient IgG, must be serotype specific
What causes glasser's disease?
What is Glasser's disease?
porcine polyserositis and arthritis
a disease of intensification
can cause acute explosive outbreaks in naive farms
How many serotypes of Glasser's disease are there?
many untypable serotypes
some are normal flora
What are the criteria such that an isolation of haemophilus parasuis is considered biologically significant?
be from clinical animal and lesionsal tissue!
What are the most virulent serotypes for haemophilus parasuis?
4, 5, 13
What serotypes of haemophilus parasuis are covered in the vaccine?
What is the pathogenesis of haemophilus parasuis?
1. early colonizer of nasal cavity (nonpathogenic)
2. ultrashort incubation following infection with virulent strain
3. poor cross protection
4. epithelial invasion, purulent rhinitis, septicemia
5. fibrinosuppurative polyserositis
6. DIC (peracute)
What are the clinical signs of haemophils parasuis?
1. peracute: found dead
2. acute: convulsions, joint swelling and pain
3. chronic: lameness, coughing, dyspnea, weight loss
What is the pathology of haemophilus parasuis?
fibrinosuppurative exudate (bread and butter)
on single or multiple serosal surfaces
How is haemophilus parasuis diagnosed
1. serotyping (many untypable)
2. serology--sertype specific ELISA
3. DNA fingerprinting