Flashcards in Diarrhea of grow-finish and adult swine Deck (53)
What are the two main diarrheic dz of adult swine?
1. necroproliferative enteritis
2. swine dysentery
What is necroproliferative enteritis?
A group of prevalent ACUTE and CHRONIC conditions of widely differing clinical signs but ith a COMMMON UNDERLYING PATHOLOGY
What are the three chronic manifestations of necroproliferative enteritis?
PIA--porcine intestinal adenomatosis
What is PIA?
Porcine intestinal adenomatosis (proliferative enteropathy)
What is NE?
Necrotic enteritis (coagulative necrosis of mucosa)
What is RI?
regional ileitis (granulomatous inflammation, hypertrophy of muscle layers)
Who gets the chronic manifestation of necroproliferative enteritis?
grower and finisher hogs
Who gets the acute manifestation of necroproliferative enteritis?
finisher hogs and adults
What is PHE?
an acute manifestation of necroproliferative enteritis
Proliferative hemorrhagic enteropathy--severe GIT hemorrhage
How is necroproliferative enteritis transmitted?
What is the pathogen responsible for necroproliferative enteritis?
When are animals exposed to lawsonia intracellularis (chronic form)
late nursery or early grower
What is the incubation period of chronic necroproliferative enteritis
What are the clinical signs of chronic necroproliferative enteritis?
1. diarrhea (50%)
2. slow growth
3. weight loss
(more severe signs associated with increasing mucosa/muscle layer involvement)
What is the pathogenesis of chronic necroproliferative enteritis?
1. intracellular invasion of intestinal crypt cells (affintiy for immature)
2. proliferation of immature crypt cells (don't mature)
What is the consequence of proliferation of immature crypt cells in chronic necroproliferative enteritis?
thickened mucosa (SI and colon)
hose-pipe gut (ileum)
What are the lesions of porcine intestinal adenomatosis?
no necrosis, only mucosal proliferation mainly ileum
corrugated hyperplastic appearance. Homogenous diarrhea
What area of the gut does lawsonia intracellularis most typically affect?
the ileum (less common colon and caecum)
What area of the intestine does lawsonia intracellularis affect that swine dystentery (brachyspira) does not affect?
What are the lesions of necrotic enteritis?
necrotic membrane on the thickened intestine? may slough off
What are the lesions of regional ileits?
smooth muscle hypertrophy occurs when the necrotic mucous membrane has sloughed away
Is regional ileitis common or rare?
rare, most pigs die before this
What is the progression through the types of chronic necroproliferative enteritis?
What are the clinical signs of acute necroproliferative enteritis? (proliferative hemorrhagic enteritis)
2. acute/peracute death
What is the pathogenesis of proliferative hemorrhagic enteritis?
Degeneration of epithelial cells, leakage of capillary beds
=>acute hemorrhage in upper SI
What are DDX for PHE in young boars?
What animals are at risk for proliferative hemorrhagic enteritis?
older finisher hogs
gilts and boars (breeding)
What are the lesions of PHE
dark digestd blood in colon. ileal serosa markedly corrugated.
How is necroproliferative enteritis diagnosed?
1. gross pathology
2. stains for intracellular bacteria
4. PCR feces of tissue
5. serology--poor, low Ig