Flashcards in Neonatal diarrheas (swine) Deck (46)
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1
What are the two causes of neonatal diarrheas?
1. colibacillosis (ETEC)
2. transmissible gastroenteritis virus (TGE)
2
What are the two causes of neonatal diarrheas?
1. colibacillosis (ETEC)
2. transmissible gastroenteritis virus (TGE)
3
What age of animals get neionatal colibacillosis?
4
What is the source of ETEC?
environment, feces skin
5
What provides a protective immunity against ETEC for piglets
pre-farrowing vaccination
6
What is a risk factor for ETEC?
litters of young sows due to lower IgA in milk
7
What is the pathogenesis of ETEC?
1. adherence to small intestinal mucosa by fimbriae (F4, F5, F6, F41)
2. colonization
3. production of enterotoxins (STa, STb, LT)
4. secretory diarrhea
8
What are the clinical signs of ETEC?
1. diarrhea, dehydration, lethargy,d eath
2. peracute--death before dehydration
3. single or multiple piglets in litter affected
9
What does severity of ETEC depend on?
1. virulence
2. vaccination status of damn
3. environmental factors
10
How can cold cause a vicious cycle with ETEC?
Piglets have little brown fat, chill quickly (diarrhea, not eating)
Slows down GI tract and e. coli stay and propagate and secrete
11
What is the trend with litters affected and ETEC?
tends to have high prevalence within a litter but not necessarily between litters
12
What is seen on pathology ith ETEC?
1. dehydration
2. dilated, fluid filled smal intesteine
3. congestion of SI vasculature
4. dilated stommach--may contain undigested curd
13
What piglets should be submitted to diagnose ETEC?
1. acute
14
What piglets should be submitted to diagnose ETEC?
1. acute
15
What age of animals get neionatal colibacillosis?
16
What is the source of ETEC?
environment, feces skin
17
What provides a protective immunity against ETEC for piglets
pre-farrowing vaccination
18
What is a risk factor for ETEC?
litters of young sows due to lower IgA in milk
19
What is the pathogenesis of ETEC?
1. adherence to small intestinal mucosa by fimbriae (F4, F5, F6, F41)
2. colonization
3. production of enterotoxins (STa, STb, LT)
4. secretory diarrhea
20
What are the clinical signs of ETEC?
1. diarrhea, dehydration, lethargy,d eath
2. peracute--death before dehydration
3. single or multiple piglets in litter affected
21
What two types of TGE infections can occur?
epizootic infection (naive herd) enzootic infection (endemic)
22
How can cold cause a vicious cycle with ETEC?
Piglets have little brown fat, chill quickly (diarrhea, not eating)
Slows down GI tract and e. coli stay and propagate and secrete
23
What is the trend with litters affected and ETEC?
tends to have high prevalence within a litter but not necessarily between litters
24
What is seen on pathology ith ETEC?
1. dehydration
2. dilated, fluid filled smal intesteine
3. congestion of SI vasculature
4. dilated stommach--may contain undigested curd
25
How is dx of ETECC done?
1. history--age of onset, gilt liters
2. alkaline (secretory diarrhea)
3. gut loop--culture and sensitivity
4. histopathology--minimal villus atrophy
5. PCR--fimbriae, enterotoxin genes
26
What piglets should be submitted to diagnose ETEC?
1. acute
27
How is ETEC prevented/controlled?
1. prevent chilling
2. sanitation and hygiene
3. stop fostering
4. commercial killed bacterns (F4, F5, F6, F4, Sta, Stb, LT)
5. autogenous bacterins--farm specific
6. prevent dehydration (electrolytes)--not too much
7. antimicrobial
28
How do you get an autogenous vaccine for ETEC?
submit rectal swabs
submit e. coli isolated
test virulence
prepare vaccine
29
what antimicrobials should be used for ETEC?
1. parenteral
ceftiofur, TMS
NOT penicillin
30
