basic glomerulonephritis overview (1a) Flashcards Preview

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Flashcards in basic glomerulonephritis overview (1a) Deck (20):
1

what causes immune mediated destruction of the glomerulus in glomerulonephritis

immune complex (antibody-antigen) driven attack or cell mediated attack on the micro structures of the kidney

2

what is the general process that glomerulonephritis destroys the kidney?

immune mediated destruction

3

what cells are considered "killer" immune response cells

CD8 T-cells

4

what are 5 common types of GN (glomerulonephritis)

1. minimal change nephropathy
2 Focal segmental glomerulosclerosis
3. membranous nephropathy
4. Immunoglobulin A nephropathy
5. lupus nephritis

5

what are two important compnents of glomerulus?

1. filtration barrier
2. mesangium (scaffolding)

6

what are the 3 layers of the capillary wall of the glomerulus?

1. fenestrated endothelium (inside of vessel)
2. glomerular basement membrane
3. epithelial cell layer (podocytes)

7

where are podocytes located?

outside of glomerulus, in the urinary space

8

what is the foot process

interlinking of podocytes that keep small particles pass into urine

9

what is the charge of the glomerular basement membrane?

the glomerular basement membrane has a negative charge, making positively charged particles more likely to enter urinary space

10

what is the normal glomerular anatomy and function?

the glomerulus is a capillary bed that keeps larger particles in the blood, and smaller molecules to pass to urine

11

what is the number one cause of end stage renal failure?
number 2?
number 3?

#1 = diabetes
#2. = hypertension
#3 - glomerularnephritis

12

what does the word humoral mean?

antibody (can be dissolved in blood)

13

what cells identify antigens?

cd4 Tcells

14

what is the mechanism behind GN

immune mediated response

15

what is the term for one side glomerulus being affected and one not being affected?

segmental

16

what term refers to involving all the glomeruli?

diffuse

17

what term refers to involving only some but not all the glomeruli

focal

18

what term refers to involving scarring of the glomerulus

slerotic

19

what are the 3 primary mechanisms of glomerular injury

1. circulating immune complex deposition
2. in situ antigen-antibody interaction
- antigen implanted or part of the glomerulus
3. cell mediated mechanism (cd4 tcells recruiting killer cd8 tcells)

20

a circulating immune complex refers to what damage the kidney

antigen-antibody complex that has already interacted that gets deposited/ collected on the kidney