Flashcards in basic glomerulonephritis overview (1a) Deck (20):
what causes immune mediated destruction of the glomerulus in glomerulonephritis
immune complex (antibody-antigen) driven attack or cell mediated attack on the micro structures of the kidney
what is the general process that glomerulonephritis destroys the kidney?
immune mediated destruction
what cells are considered "killer" immune response cells
what are 5 common types of GN (glomerulonephritis)
1. minimal change nephropathy
2 Focal segmental glomerulosclerosis
3. membranous nephropathy
4. Immunoglobulin A nephropathy
5. lupus nephritis
what are two important compnents of glomerulus?
1. filtration barrier
2. mesangium (scaffolding)
what are the 3 layers of the capillary wall of the glomerulus?
1. fenestrated endothelium (inside of vessel)
2. glomerular basement membrane
3. epithelial cell layer (podocytes)
where are podocytes located?
outside of glomerulus, in the urinary space
what is the foot process
interlinking of podocytes that keep small particles pass into urine
what is the charge of the glomerular basement membrane?
the glomerular basement membrane has a negative charge, making positively charged particles more likely to enter urinary space
what is the normal glomerular anatomy and function?
the glomerulus is a capillary bed that keeps larger particles in the blood, and smaller molecules to pass to urine
what is the number one cause of end stage renal failure?
#1 = diabetes
#2. = hypertension
#3 - glomerularnephritis
what does the word humoral mean?
antibody (can be dissolved in blood)
what cells identify antigens?
what is the mechanism behind GN
immune mediated response
what is the term for one side glomerulus being affected and one not being affected?
what term refers to involving all the glomeruli?
what term refers to involving only some but not all the glomeruli
what term refers to involving scarring of the glomerulus
what are the 3 primary mechanisms of glomerular injury
1. circulating immune complex deposition
2. in situ antigen-antibody interaction
- antigen implanted or part of the glomerulus
3. cell mediated mechanism (cd4 tcells recruiting killer cd8 tcells)