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Flashcards in HTN6 Deck (29):
1

what is the trade name of doxazosin

Cardura

2

what is the trade name of Prazosin

Minipress

3

what is the trade name of Terazosin

Hytrin

4

what drugs are only used in combo therapy for BPH?

alpha blockers

5

what is the MOA of direct renin inhibitors

directly inhibits renin at beginning of RAAS

6

what are the adverse effects of Direct Renin Inhibitors?

angioedema
increased Scr and BUN
increased K

7

what is the contraindication for direct renin inhibitors?

pregnancy

8

what are the central a2 agonists trade and generic names?

clonidine - Catapres
Clonidine patch - Catapres-TTS
Methyldopa - Aldomet
Guanfacine (Tenex)

9

what is the MOA of central A2 agonists

stimulate A2 receptors in brain which inhibits release of NE

10

what are the effects of central a2 agonists on:
1. sympathetic outflow
2. vagal outflow

1. decrease sympathetic outflow
2. increase vagal outflow

11

what makes central A2 agonists most effective?

used with a diuretic to reduce fluid retention

12

what central A2 agonist can be used by itself?

clonidine

13

what is the oral dosing of clonidine?
what is max dose?

.1 mg BID up to 1.2 mg per day

14

what is the transdermal dosing of clonidine

.1, 0.2, 0.3 mg/day patch every 7 days

15

what effect does clonidine typically have on BP

decreases diastolic BP by 10 mmHg

16

what dosing should be given to change from PO to transdermal patches?

day 1: patch + 100% of oral dose
day 2: 50% of oral dose
day 3: 25% oral dose
day 4: d/c PO dose

17

what are the adverse effects of clonidine

1. sedation
2. orthostatic hypotension
3. depression
4. dry mouth

18

what is the "rebound phenomenon"

heart compensating for loss of pressure and volume

19

what is the first line treatment for HTN in pregnancy

methyldopa

20

what is the MOA with peripheral adrenergic agonists

depletes norepinephrine from sympathetic nerve endings and blocks transport of NE into storage granules

21

what are the effects of peripheral adrenergic antagonists on sympathetic tone and PVR?

decreases sympathetic tone
decreases PVR due to vasodilation

22

what are the adverse effects of peripheral adrenergic antagonists?

1. CNS effects (sedation, anxiety, depression)
2. nasal stuffiness
3. peptic ulcer
4. orthostatic hypotention

23

what is a peripheral adrenergic antagonist

reserpine

24

what type of drug is hydralazine

direct arterial vasodilator

25

what are the effects of compensatory mechanisms seen with hydralazine

increase HR, CO and renin release

26

what is the dosing of hydralzine?

TID or QID

27

when using a thiazide diuretic, potassium does what? what does uric acid do

K decreases
uric acid increases

28

what is bp goal in a diabetic patient with HTN
what is most appropriate 1st line therapy?

140/90
HCTZ

29

a black male with DM and HTN who has been on hydroclorothiazide for a month should have what added?
a. amlodipine
b. enalapril
c. hydralazine
d. chlorthalidone

amlodipine (CCB preferred)