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Flashcards in HTN3 Deck (20):
1

what are the 3 major groups of antiHTN agents

1. volume depleters
2. adrenergic inhibitors
3. vasodilators

2

what antiHTN agents are considered vasodilators?

ACEI
CCB
ARB

3

what antiHTN agents are considered volume depleters?

diuretics

4

what is the MOA of thiazides on HTN initially

Initially:
decrease extracellular fluid volume
decrease cardiac output and BP
increase systemic vascular resistance (SVR)

5

what is the MOA of thiazides on HTN chronically

decrease systemic vascular resistance due to compensation

6

list the thiazide diuretics

1. hydrocholorothiazide
2. indapamide
3. metolazone
4. chlorthalidone
5. indapamide

7

why are thiazides preferred in combo therapy

synergistic affect by blocking compensatory fluid (and Na) retention mechanisms

8

what patients should not be given thiazide diuretics for HTN?
why

patients with renal failure (CrCl < 30)
thiazides compete with endogenous organic acids that build up in renal insufficiency

9

what effect does thiazide have on arteriolar walls

mobilize sodium and Na from arteriolar walls, reducing pressure on lumen

10

what effect do thiazide diuretics have on the lumen of a vessel?

What can blunt this effect?

lumen relaxes and diameter increases

high dietary sodium

11

what electrolytes may be adversely increased due to thiazides

increased calcium
increased uric acid
increased glucose

12

what electrolytes may be adversely decreased due to thiazides

decreased potassium
decreased sodium
decreased magnesium

13

what type of drugs most commonly cause electrolyte imbalances

Thiazides

14

patients with gout should avoid what class of drugs?
why?

thiazides
increases uric acid levels, people w/ gout should never take thiazides

15

what drugs can be used to counterbalance thiazides effects on potassium

ACEI cause hyperkalemia
thiazides cause hypokalemia

16

what adverse effect of thiazides should be transient?

orthostatic hypotension

17

what are 3 adverse effects of thiazides

electrolyte disturbances
orthostatic hypotension
sexual dysfunction

18

what should be monitored when on thiazides

1. BP
2. renal function (BUN and SrCr)
3. electrolytes
4. glucose
5. uric acid

19

what effects do loop diuretics have on K and Ca?

decrease K and Ca

20

list the K-sparing diuretics

1. spironolactone
2. triamterene
3. amiloride
4. eplerenone