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Flashcards in glomerular injury Deck (19):
1

what are 3 ways an in situ antigen antibody interaction may develop glomerular injury

1. glomerular antigen attacked by immune system
2. basement membrane antigen attacked by immune system
3. exogenous planted antigen that landed on kidney (either virus or kidney)

2

what type of antibody can damgage by glomerular cell by settling on epithelial cell surface?

Iga
noncomplement-fixing antibody
(IgA necropathy)

3

what is the membrane attack complex (MAC)

a complement system that is activated and acts as a pour into the kidney

4

inflammatory lesions in the kidney leading to damage involves infiltration of what cells?

neutrophils
monocytes/ macrophages
platelets

5

overgrowth of what cells can cause glomerular basement damage?

glomerular mesangial cell overgrowth

6

what antibody is considered noncomlimentory

Iga

7

damaged podocytes can lead to what?

loss of normal slit penetration leading to loss of albumin and immunoglobins
proteinuria

8

nephrotic syndrome is characterized by what?

lots of protein loss, no inflammatory injury. Few cells and casts in the urine

9

nephritic syndrome is characterized by what?

glomerular inflammation resulting in hematuria, white cells and granular casts in the urine

10

minimal change nephropathy is a feature of what?

nephrotic syndrome

11

what occurs when red blood cells leak through openings of the GBM?

hematuria

12

what is normal range of protein loss in urine

40-80 mg/ day

13

what are 5 characteristics of nephritic syndrome

1. patients typically not too distressed
2. hematuria
3. hypertension
4. white cells in urine (pus)
5. casts in urine (cellular and granular)

14

what is the typical amount of proteinuria in nephritic syndrome?

less than 3 grams per day

15

what is the typical proteinuria in nephrotic syndrome

more than 3.5 grams/day

16

what are 5 characteristics of nephrotic syndrome?

1. patients are fatigued
2. weight gain
3. edema
4. hyperlipidemia

17

why is weight gain typical with nephrotic syndrome?

loss of albumin causes water to leave blood vessels

18

what type of GN usually has white cells in urine

nephritic syndrome

19

what type of GN can lead to lipidurea

nephrotic syndrome