HTN5

Question 1

what are the trade names for nifedipine

Answer 1

Procardia and Adalat

Question 2

what is the trade name for amlodipine?

Answer 2

Norvasc`

Question 3

what is the trade name for felodipine

Answer 3

Plendil

Question 4

what is the trade name for Nicardipine

Answer 4

Cardene

Question 5

what is the trade name for isradipine

Answer 5

DynaCirc

Question 6

What are the trade names fo Verapamil

Answer 6

Calan, Isoptin, and Verelan

Question 7

what are the trade names for Diltiazem?

Answer 7

Cardizem and Dilacor

Question 8

what abbreviations mean daily

Answer 8

CD and XR

Question 9

what abbreviation means BID

Answer 9

SR

Question 10

what are beta blockers effects on:

1. CO
2. renin release
3. PVR

Answer 10

decreases all 3 (CO, renin release, and PVR with chronic use)

Question 11

what are the adverse effects of beta blockers

Answer 11

1. bradycardia
2. second or third degree heart block
3. Acute heart failure
4. CNS effects
5. sexual dysfunction
6. discontinuation syndromes

Question 12

how are discontinuation syndromes with BB’s avoided

Answer 12

taper gradually over 1-2 weeks

Question 13

what are the adverse effects of BB’s on the CNS

Answer 13

fatigue
insomnia
bizarre dreams
depression

Question 14

what causes fatigue with BB’s

Answer 14

compensation mechanisms of heart slows it down

Question 15

what is the cardioselectivity of beta blockers

Answer 15

dose dependent B1 selectivity

-high doses give less selectivity for B1

Question 16

what refers to both the beta blocking and partial beta stimulating effects of beta clockers in the resting state?

Answer 16

Intrinsic Sympathomimetic Activity (ISA)

Question 17

Beta blockers with high ISA do not treat what as well as other BBs?

Answer 17

CV events

Question 18

what is associated with high lipid solubility in BB

Answer 18

high lipid solubility increases CNS effects

Question 19

what are the combined, alpha and beta antagonists (classified as BBs)

Answer 19

labetalol

Carvedilol

Question 20

describe the selectivity of labetolol

Answer 20

nonselective B1 and B2 blocker

highly selective for a1 receptors

Question 21

describe the receptor selectivity for Carvedilol

Answer 21

nonselective for B1, B2, and a1

Question 22

what is the trade name of labetalol

Answer 22

Normodyne

Question 23

what is the trade name of Carvedilol

Answer 23

Coreg

Question 24

what are the contraindications for BBs

Answer 24

1. Heart Block
2. Bradycardia
3. Asthma/ COPD
4. Noncompliance
5. Diabetics

Question 25

why should BB not be used with diabetics

Answer 25

exacerbate hyperglycemia

Question 26

what should be monitored with pts on BBs

Answer 26

BP and HR

Question 27

what BBs have high lipid solubility

Answer 27

propranolol and carvedilol

Question 28

what BB has high ISA

Answer 28

Pindolol (VIsken)

Question 29

what is the 1st dose phenomenon with alpha blockers?

Answer 29

dizziness, faintness, palpitations and syncope

transient

Question 30

when should first dose of alpha blockers be given?

Answer 30

at bedtime

Question 31

what is the MOA of alpha blockers

Answer 31

blocks activation of post-synaptic a1 receptors

Question 32

what are the side effects of alpha blockers

Answer 32

1. first dose effects
2. orthostatic hypotension
3. Na/ H2O retention