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Flashcards in HTN5 Deck (32):
1

what are the trade names for nifedipine

Procardia and Adalat

2

what is the trade name for amlodipine?

Norvasc`

3

what is the trade name for felodipine

Plendil

4

what is the trade name for Nicardipine

Cardene

5

what is the trade name for isradipine

DynaCirc

6

What are the trade names fo Verapamil

Calan, Isoptin, and Verelan

7

what are the trade names for Diltiazem?

Cardizem and Dilacor

8

what abbreviations mean daily

CD and XR

9

what abbreviation means BID

SR

10

what are beta blockers effects on:
1. CO
2. renin release
3. PVR

decreases all 3 (CO, renin release, and PVR with chronic use)

11

what are the adverse effects of beta blockers

1. bradycardia
2. second or third degree heart block
3. Acute heart failure
4. CNS effects
5. sexual dysfunction
6. discontinuation syndromes

12

how are discontinuation syndromes with BB's avoided

taper gradually over 1-2 weeks

13

what are the adverse effects of BB's on the CNS

fatigue
insomnia
bizarre dreams
depression

14

what causes fatigue with BB's

compensation mechanisms of heart slows it down

15

what is the cardioselectivity of beta blockers

dose dependent B1 selectivity
-high doses give less selectivity for B1

16

what refers to both the beta blocking and partial beta stimulating effects of beta clockers in the resting state?

Intrinsic Sympathomimetic Activity (ISA)

17

Beta blockers with high ISA do not treat what as well as other BBs?

CV events

18

what is associated with high lipid solubility in BB

high lipid solubility increases CNS effects

19

what are the combined, alpha and beta antagonists (classified as BBs)

labetalol
Carvedilol

20

describe the selectivity of labetolol

nonselective B1 and B2 blocker
highly selective for a1 receptors

21

describe the receptor selectivity for Carvedilol

nonselective for B1, B2, and a1

22

what is the trade name of labetalol

Normodyne

23

what is the trade name of Carvedilol

Coreg

24

what are the contraindications for BBs

1. Heart Block
2. Bradycardia
3. Asthma/ COPD
4. Noncompliance
5. Diabetics

25

why should BB not be used with diabetics

exacerbate hyperglycemia

26

what should be monitored with pts on BBs

BP and HR

27

what BBs have high lipid solubility

propranolol and carvedilol

28

what BB has high ISA

Pindolol (VIsken)

29

what is the 1st dose phenomenon with alpha blockers?

dizziness, faintness, palpitations and syncope
transient

30

when should first dose of alpha blockers be given?

at bedtime

31

what is the MOA of alpha blockers

blocks activation of post-synaptic a1 receptors

32

what are the side effects of alpha blockers

1. first dose effects
2. orthostatic hypotension
3. Na/ H2O retention