HTN5 Flashcards
what are the trade names for nifedipine
Procardia and Adalat
what is the trade name for amlodipine?
Norvasc`
what is the trade name for felodipine
Plendil
what is the trade name for Nicardipine
Cardene
what is the trade name for isradipine
DynaCirc
What are the trade names fo Verapamil
Calan, Isoptin, and Verelan
what are the trade names for Diltiazem?
Cardizem and Dilacor
what abbreviations mean daily
CD and XR
what abbreviation means BID
SR
what are beta blockers effects on:
- CO
- renin release
- PVR
decreases all 3 (CO, renin release, and PVR with chronic use)
what are the adverse effects of beta blockers
- bradycardia
- second or third degree heart block
- Acute heart failure
- CNS effects
- sexual dysfunction
- discontinuation syndromes
how are discontinuation syndromes with BB’s avoided
taper gradually over 1-2 weeks
what are the adverse effects of BB’s on the CNS
fatigue
insomnia
bizarre dreams
depression
what causes fatigue with BB’s
compensation mechanisms of heart slows it down
what is the cardioselectivity of beta blockers
dose dependent B1 selectivity
-high doses give less selectivity for B1
what refers to both the beta blocking and partial beta stimulating effects of beta clockers in the resting state?
Intrinsic Sympathomimetic Activity (ISA)
Beta blockers with high ISA do not treat what as well as other BBs?
CV events
what is associated with high lipid solubility in BB
high lipid solubility increases CNS effects
what are the combined, alpha and beta antagonists (classified as BBs)
labetalol
Carvedilol
describe the selectivity of labetolol
nonselective B1 and B2 blocker
highly selective for a1 receptors
describe the receptor selectivity for Carvedilol
nonselective for B1, B2, and a1
what is the trade name of labetalol
Normodyne
what is the trade name of Carvedilol
Coreg
what are the contraindications for BBs
- Heart Block
- Bradycardia
- Asthma/ COPD
- Noncompliance
- Diabetics
