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Flashcards in more GN disease states Deck (24):
1

what is also known as berger disease

IgA nephropathy

2

what type of GN often leads to thrombosis

membranous nphropathy

3

what is the only type of GN that chlorambucil is used in

membranous nephropathy

4

IgA has what type of structure

pentamer

5

what is usual presenting symptom with immunoglobin A nephropathy

infection and peeing blood

6

who is mostly effected by Berger disease

young males ( prevalent in Japan)

7

what is the pathophysiology of Berger disease

IgA deposits on kidney triggering immune response.
immune complex mediated disease

8

what percent of Iga nephropathy pt.s progress to ESRD in 10 years

10-20%

9

what is the most common symptom coupled with IgA nephropathy?

respiratory infections

10

what is uncommon at presentation of IgA nephropathy

renal dysfunction

11

what non-pharm treatment is common with IgA nephropathy

gluten free diets (gluten causes immune response)

12

what are common drugs used in IgA nephropathy tx?

1. phenytoin - reduces circulating IgA
2. Steroids - reduce proteinuria and ESRD progression
3. fish oil - reduce prostaglandin and leukotriene production
4. ACE and ARB's for all pt's

13

what is the only disease state that uses fish oil?

IgA nephropathy

14

gluten free diets is included with what type of GN?

Immunoglobulin A Nephropathy

15

what is the only type of GN treated with fish oil

Immunoglobulin A Nephropathy

16

lupus nephritis is a complication of what

system lupus erythematosus

17

who is most effected by lupus nephritis

young African American women

18

what is needed to confirm diagnosis of lupus nephritis?

biopsy

19

is lupus nephrotic or nephritic

both, not just one or the other

20

the pathophysiology of lupus nephritis predominately effects what?

B-cells (become hyperactive), producing more autoantibodies.

21

lupus symptoms/ presentation has what?

red cells (looks nephritic) in urine
ranges from hematuria and proteinuria
HTN

22

what types of treatment are given for lupus nephritis

methylprednisolone followed by prednisone taper
combined with cyclophosphamide or mycophenolate

23

what other treatment is given for lupus nephritis for resistant cases

rituximab

24

what is the MOA of rituximab

inhibits CD20 on B-cells, taking them out of circulation
or
Depeletes immature B Cells